Publication
これまでの研究成果を紹介します.
これまでの研究成果を紹介します.
*はCorresponding author.
査読あり業績とプレプリントのみ記載しています.その他詳しくはResearch mapへ.
Ono S, Takebe K, Tosa I, Nishiya Y, Nakayama M, Wada T, Takashiba S, Ohara N. PGN_0298 in the Assembly and insertion machinery (Aim) operon is essential for the viability of Porphyromonas gingivalis. Microbiol Immunol. 2025. Ahead of print. doi: 10.1111/1348-0421.70021.
歯周病菌
Seto J, Inoue S, Abe S, Terashita K, Endo Y, Fujii S, Sasaki Y, Kato Y, Yamashita H, Murase Y, Mitarai S, Ikeda T, Mizuta K, Ahiko T, Wada T*. A case of endogenous and collateral reactivation caused by two Mycobacterium tuberculosis subclones. J Infect Chemother. 2025. 31(10):102795. doi: 10.1016/j.jiac.2025.102795.
結核
Yamamoto K, Takeuchi S, Nakaya T, Fujiwara N, Seto J, Komukai J, Tsuda Y, Yoshida H, Wada T. Geodemographic analysis of socioeconomic area disparities in tuberculosis incidence in Osaka City, Japan. Sci Rep. 2025. 15(1):15968. doi: 10.1038/s41598-025-99711-4.
結核
Akapelwa ML, Kapalamula TF, Moonga LC, Bwalya P, Solo ES, Chizimu JY, Thapa J, Hayashida K, Hang'ombe BM, Munyeme M, Tamaru A, Wada T, Yoshida S, Kodera T, Kawase M, Gordon SV, Yamada K, Nakajima C, Suzuki Y. Development of a multiplex loop-mediated isothermal amplification (LAMP) method for differential detection of Mycobacterium bovis and Mycobacterium tuberculosis by dipstick DNA chromatography. Microbiol Spectr. 2025. e0242124. doi: 10.1128/spectrum.02421-24.
結核
Ito H, Wada T, Ichinose G, Tanimoto J, Yoshimura J, Yamamoto T, Morita S. Barriers to the widespread adoption of diagnostic artificial intelligence for preventing antimicrobial resistance. Sci Rep. 2025.15(1):13113. doi: 10.1038/s41598-025-95110-x.
抗生剤耐性・社会的ジレンマ
Uemura K, Sato T, Yamamoto S, Ogasawara N, Toyting J, Aoki K, Takasawa A, Koyama M, Saito A, Wada T, Okada K, Yoshida Y, Kuronuma K, Nakajima C, Suzuki Y, Horiuchi M, Takano K, Takahashi S, Chiba H, Yokota SI. Rapid and Integrated Bacterial Evolution Analysis unveils gene mutations and clinical risk of Klebsiella pneumoniae. Nat Commun. 2025. 16(1):2917. doi: 10.1038/s41467-025-58049-1.
肺炎桿菌
Inoue H, Tanimoto Y, Zheng D, Ban-Furukawa E, Inoue M, Omori Y, Yamaguchi Y, Tachibana T, Aso H, Zhang W, Kage-Nakadai E, Nishikawa Y, Wada T*. An atypical kappa-class chaperone-usher fimbriae of a human enterotoxigenic Escherichia coli strain shows multi-host adherence and distinct phylogenetic feature. Microbiol Immunol. 2025. 69(5):270-279. doi: 10.1111/1348-0421.13208.
大腸菌接着因子
Ali MS, Ahmed S, Tanimoto Y, Wada T*, Kage-Nakadai E. Lactococcus lactis subsp. lactis boosts stress resistance and host defense mechanisms in Caenorhabditis elegans. J Appl Microbiol. 2025. 136(1):lxaf016. doi: 10.1093/jambio/lxaf016.
乳酸菌・プロバイオティクス
Hashimoto M, Tanimoto Y, Chen YL, Wada T, Kage-Nakadai E. Complete genome sequence of Lactiplantibacillus brownii strain MH-1 isolated from Japanese traditional homemade pickled Chinese cabbage. Microbiol Resour Announc. 2025. 14(2):e0106424. doi: 10.1128/mra.01064-24.
乳酸菌
Sun Q, Wada T, Liao CS. Editorial: Recent advances in bioremediation of emerging contaminants and endocrine disruptors. Front Microbiol. 2024. 15:1383770. doi: 10.3389/fmicb.2024.1383770.
バイオレメディエーション
Wada T*, Yoshida S, Yamamoto T, Nonaka L, Fukushima Y, Nakajima C, Suzuki Y, Imajoh M. Application of genomic epidemiology of pathogens to farmed yellowtail fish Mycobacteriosis in Kyushu, Japan. Microb Environ. 2024. 39(2): ME24011. doi: 10.1264/jsme2.ME24011.
動物の抗酸菌症
Matsuda A, Ishida T, Tanimoto Y, Wada T, Kage-Nakadai E. Pathogenicity of enterotoxigenic Escherichia coli in Caenorhabditis elegans as an alternative model host. Biosci Biotechnol Biochem. 2024. 88(4):453-459. doi: 10.1093/bbb/zbad185.
病原性大腸菌
Ali MS, Yoshida S, Ahmed S, Takeuchi S, Wada T, Kage-Nakadai E. Improvement of locomotion caused by Lactococcus lactis subsp. lactis in the model organism Caenorhabditis elegans. Nutrients 2023. 15(20), 4482. doi: 10.3390/nu15204482.
乳酸菌・プロバイオティクス
Imajoh M, Yoshida S, Nonaka L, Fukushima Y, Nakajima C, Suzuki Y, Wada T*. Retrospective identification of pathogenic mycobacterial species in fish: Mycobacterium pseudoshottsii YM-3, isolated from a yellowtail fish in 1986 in Kochi, Japan. Microbiol Resour Announc. 2023. 12(10):e0049823. doi: 10.1128/MRA.00498-23.
動物の抗酸菌症
Komatsu T, Ohya K, Ota A, Nishiuchi Y, Yano H, Matsuo K, Odoi JO, Suganuma S, Sawai K, Hasebe A, Asai T, Yanai T, Fukushi H, Wada T, Yoshida S, Ito T, Arikawa K, Kawai M, Ato M, Baughn AD, Iwamoto T, Maruyama F. Unique genomic sequences in a novel Mycobacterium avium subsp. hominissuis lineage enable fine scale transmission route tracing during pig movement. One Health 2023. 100559. doi: 10.1016/j.onehlt.2023.100559.
非結核性抗酸菌
Teramoto N, Sato K, Wada T, Nishikawa Y, Kage-Nakadai E. Impacts of Bacillus subtilis var. natto on the lifespan and stress resistance of Caenorhabditis elegans. Appl Environ Microbiol. 2023. 134(4):lxad082. doi: 10.1093/jambio/lxad082.
納豆菌・プロバイオティクス
瀬戸順次,三瓶美香,水田克巳,和田崇之,下村佳子,御手洗聡,村瀬良朗,細谷真紀子,阿彦忠之.山形県における結核菌ゲノム解析を用いた結核分子疫学調査.感染症学雑誌 2023. 97(1):6–17. doi: 10.11150/kansenshogakuzasshi.e22021.
結核
Ito H, Wada T, Ichinose G, Tanimoto J, Yoshimura J, Yamamoto T, Morita S. Social dilemma in the excess use of antimicrobials incurring antimicrobial resistance. Sci Rep. 2022. 12(1):21084. doi: 10.1038/s41598-022-25632-1.
抗生剤耐性・社会的ジレンマ
Arima H, Calliope AS, Fukuda H, Nzaramba T, Mukakarake MG, Wada T, Yorifuji T, Mutesa L, Yamamoto T. Oral cleaning habits and the copy number of periodontal bacteria in pregnant women and its correlation with birth outcomes: an epidemiological study in Mibilizi, Rwanda. BMC Oral Health. 2022. 22(1):428. doi: 10.1186/s12903-022-02443-4.
口腔内細菌
Fujiwara N, Onaga T, Wada T, Takeuchi S, Seto J, Nakaya T, Aihara K. Analytical estimation of maximum fraction of infected individuals with one-shot non-pharmaceutical intervention in a hybrid epidemic model. BMC Infect Dis. 2022. 22(1):512. doi: 10.1186/s12879-022-07403-5.
感染症数理
Koizumi N, Morita M, Nuradji H, Susanti, Noor SM, Dharmayanti NLPI, Randusari P, Mu JJ, Solante RM, Saito N, Ariyoshi K, Ha HTT, Wada T, Akeda Y, Miura K. Comparative genomic analysis of Leptospira spp. isolated from Rattus norvegicus in Indonesia. Infect Genet Evol. 2022. 102:105306. doi: 10.1016/j.meegid.2022.105306.
レプトスピラ
Arimura Y, Minato Y, Wada T, Nakayama M, Ryumon A, Hirata N, Nakajima C, Suzuki Y, Ato M, Kobayashi K, Ohara N, Iida S, Ohara N. Attempt of thyX gene silencing and construction of a thyX deleted clone in a Mycobacterium bovis BCG. Microbiol Immunol. 2022. 66(1):10–4. doi: 10.1111/1348-0421.12944.
BCGワクチン
Tanimoto Y, Inoue M, Komatsu K, Odani A, Wada T, Kage-Nakadai E, Nishikawa Y. Seroepidemiological survey on pigs and cattle for novel K88 (F4)-like colonisation factor detected in human enterotoxigenic Escherichia coli. Epidemiol Infect. 2022 150:e6. DOI: 10.1017/S0950268821002697.
病原性大腸菌
Komatsu T, Ohya K, Ota A, Nishiuchi Y, Yano H, Matsuo K, Odoi JO, Suganuma S, Sawai K, Hasebe A, Asai T, Yanai T, Fukushi H, Wada T, Yoshida S, Ito T, Arikawa K, Kawai M, Ato M, Baughn AD, Iwamoto T, Maruyama F. Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan. GigaByte 2021. 2021:gigabyte33. doi: 10.46471/gigabyte.33.
非結核性抗酸菌
Umeda K, Ono HK, Wada T, Motooka D, Nakamura S, Nakamura H, Hu DL. High production of egc2-related staphylococcal enterotoxins caused a food poisoning outbreak. Int J Food Microbiol. 2021. 357:109366. doi: 10.1016/j.ijfoodmicro.2021.109366.
黄色ブドウ球菌
Koizumi N, Morita M, Pheng V, Wann C, Masuoka H, Higa Y, Wada T, Hirayama K, Ohnishi M, Miura K. Rat trade and leptospirosis: Molecular epidemiology of Leptospira species in rats exported from Cambodia to Vietnam. J Transbound Emerg Dis. 2021. 69(3):1641-1648. doi: 10.1111/tbed.14077.
レプトスピラ
Suga S, Mukai Y, Ishikawa S, Yoshida S, Paudel S, Wada T. Intensive treatment of a captive Bornean elephant (Elephas maximus borneensis) infected with Mycobacterium caprae in Japan. J Zoo Wildl Med. 2021. 51(4):1067–71. doi: 10.1638/2019-0152.
動物の結核症
Arima H, Nakano M, Koirala S, Ito H, Pandey BD, Pandey K, Wada T, Yamamoto T. Unique hemoglobin dynamics in female Tibetan highlanders. Trop Med Health 2021. 49(1):2. doi: 10.1186/s41182-020-00289-6.
自然人類学
Calliope SA, Yorifuji T, Wada T, Mukakarake MG, Mutesa L, Yamamoto T. Antenatal Care Visits and Adverse Pregnancy Outcomes at a Hospital in Rural Western Province, Rwanda. Acta Med Okayama 2020. 74(6):495–503.
http://ousar.lib.okayama-u.ac.jp/ja/journal/amo/74/6/article/61209
公衆衛生学
Sato T, Wada T, Nishijima S, Fukushima Y, Nakajima C, Suzuki Y, Takahashi S, Yokota SI. Emergence of the novel aminoglycoside acetyltransferase variant aac(6′)-Ib-D179Y and acquisition of colistin heteroresistance in carbapenem-resistant Klebsiella pneumoniae due to a disrupting mutation in the DNA repair enzyme MutS. mBio 2020. 11(6):e01954-20. doi: 10.1128/mBio.01954-20.
肺炎桿菌
Yabe T, Tsubouchi K, Fujiwara N, Wada T, Sekimoto Y, Ukkusuri SV. Non-compulsory measures sufficiently reduced human mobility in Tokyo during the COVID-19 epidemic. Sci Rep. 2020. 10:18053. doi: 10.1038/s41598-020-75033-5.
COVID-19
Koizumi N†, Wada T†, Morita M, Mu JJ, Ohnishi M. Comparative genomic analysis of Leptospira borgpetersenii serogroup Javanica isolated from Rattus species in Southern Japan, Philippines, and Taiwan. Infect Genet Evol. 2020. 85:104447. doi: 10.1016/j.meegid.2020.104447.
†Equal contribution
レプトスピラ
Sato T, Wada T, Shinagawa M, Fukushima Y, Nakajima C, Suzuki Y, Takahashi S, Yokota SI. Emergence of vancomycin- and teicoplanin-resistant Enterococcus faecium via vanD5-harbouring large genomic island. J Antimicrob Chemother. 2020. 75(9):2411–5. doi: 10.1093/jac/dkaa220.
腸球菌
Odoi JO, Ohya K, Moribe J, Takashima Y, Sawai K, Taguchi K, Fukushi H, Wada T, Yoshida S, Asai T. Isolation and antimicrobial susceptibilities of nontuberculosis mycobacteria from wildlife in Japan. J Wildl Dis. 2020. 56(4):851–62. doi: 10.7589/2019-10-261.
動物の抗酸菌症
Yamamichi S, Miuma S, Wada T, Masumoto H, Kanda Y, Shibata H, Miyaaki H, Taura N, Ichikawa T, Yamamoto T, Nakao K. Deep sequence analysis of NS5A resistance-associated substitution changes in patients reinfected with the hepatitis C virus after liver transplantation. J Viral Hepat. 2020. 27(5):552–5. doi: 10.1111/jvh.13256.
C型肝炎ウイルス
Chen CC, Chang AM, Wada T, Chen MT, Tu YS. Distribution of Carnivore protoparvovirus 1 in free-living leopard cats (Prionailurus bengalensis chinensis) and its association with domestic carnivores in Taiwan. PLoS ONE 2019. 14(9):e0221990. doi: 10.1371/journal.pone.0221990.
プロトパルボウイルス
Nakamura S, Azuma M, Sato M, Fujiwara N, Nishino S, Wada T, Yoshida S. Pseudo-outbreak of Mycobacterium chimaera through aerators of hand-washing machines at a hematopoietic stem cell transplantation center. Infect Control Hosp Epidemiol. 2019. 40(12):1433–5. doi: 10.1017/ice.2019.268.
非結核性抗酸菌
Ito H, Tamura K, Wada T, Yamamoto T, Morita S. Is the network of heterosexual contact in Japan scale free? PLoS ONE 2019. 14(8): e0221520. doi: 10.1371/journal.pone.0221520. doi: 10.1371/journal.pone.0221520.
性感染症
Tsai MA, Wang PC, Yoshida S, Aono A, Mitarai S, Wada T*, Chen SC. Establishment of loop-mediated isothermal amplification for rapid and convenient detection of Mycobacterium marinum complex. J Microbiol Methods 2019. 164: 105671. doi: 10.1016/j.mimet.2019.105671.
非結核性抗酸菌
Yamashita H, Wada T, Kato Y, Ikeda T, Imajoh M. Draft genome sequences of three Flavobacterium psychrophilum strains isolated from diseased ayu (Plecoglossus altivelis altivelis) caught at three sites in Kagami River, Kochi, Japan. Microbiol Resour Announc. 2019. 8(34): e00773-19. doi: 10.1128/MRA.00773-19.
魚類冷水病
Kato Y, Wada T, Yamashita H, Ikeda T, Nishiyama K, Imajoh M. Draft genome sequence of Vibrio harveyi strain GAN1807 isolated from diseased greater amberjack (Seriola dumerili) farmed in Japan in 2018. Microbiol Resour Announc. 2019. 8(34): e00629-19. doi: 10.1128/MRA.00629-19.
魚類ビブリオ属菌
Yamashita H, Wada T, Kato Y, Ikeda T, Imajoh M. Draft genome sequences of six Flavobacterium psychrophilum strains isolated from dead juvenile ayu (Plecoglossus altivelis altivelis) near the mouth of the Nahari River, Kochi, Japan. Microbiol Resour Announc. 2019. 8(29): e00759-19. doi: 10.1128/MRA.00759-19.
魚類冷水病
Yamamoto K, Takeuchi S, Seto J, Shimouchi A, Komukai J, Hase A, Nakamura H, Umeda K, Hirai Y, Matsumoto K, Ogasawara J, Wada T*, Yamamoto T. Longitudinal genotyping surveillance of Mycobacterium tuberculosis in an area with high tuberculosis incidence shows high transmission rate of the modern Beijing subfamily in Japan. Infect Genet Evol. 2019. 72: 25–30. doi: 10.1016/j.meegid.2018.09.014.
結核
Seto J, Otani Y, Wada T, Suzuki Y, Ikeda T, Araki K, Mizuta K, Ahiko T. Nosocomial Mycobacterium tuberculosis transmission by brief casual contact identified using comparative genomics. J Hosp Infect. 2019. 102(1): 116–9. doi: 10.1016/j.jhin.2019.01.002.
結核
Parvej MS, Nakamura H, Alam MA, Wang L, Zhang S, Emura K, Kage-Nakadai E, Wada T, Hara-Kudo Y, Nishikawa Y. Host range-associated clustering based on multilocus variable-number tandem-repeat analysis, phylotypes, and virulence genes of atypical enteropathogenic Escherichia coli strains. Appl Environ Microbiol. 2019. 85(6): e02796-18. doi: 10.1128/AEM.02796-18.
病原性大腸菌
Koirala S, Nakano M, Arima H, Takeuchi S, Ichikawa T, Nishimura T, Ito H, Pandey BD, Pandey K, Wada T, Yamamoto T. Current health status and its risk factors of the Tsarang villagers living at high altitude in the Mustang district of Nepal. J Physiol Anthropol. 2018. 37(1): 20. doi: 10.1186/s40101-018-0181-y.
公衆衛生学
Yoshida S, Suga S, Ishikawa S, Mukai Y, Tsuyuguchi K, Inoue Y, Yamamoto T, Wada T. Mycobacterium caprae infection in a captive Borneo elephant. Emerg Infect Dis. 2018. 24(10): 1937–40. doi: 10.3201/eid2410.180018.
動物の結核感染症
Seto J, Wada T, Suzuki Y, Ikeda T, Araki K, Umetsu Y, Ishikawa H, Mizuta K, Ahiko T. A case of laboratory cross-contamination of Mycobacterium tuberculosis identified by comparative genomics. Int J Tuberc Lung Dis. 2018. 22(10): 1239–42. doi: 10.5588/ijtld.18.0237.
結核
Kayanuma H, Ogihara K, Yoshida S, Yamamoto K, Wada T, Yamamoto T, Tsuyuki Y, Madarame H. Disseminated nontuberculous mycobacterial disease in a cat caused by Mycobacterium sp. strain MFM001. Vet Microbiol. 2018. 220: 90–6. doi: 10.1016/j.vetmic.2018.05.010.
動物の抗酸菌症
Yoshida S, Araki T, Asai T, Tsuyuguchi K, Arikawa K, Iwamoto T, Nakajima C, Suzuki Y, Ohya K, Yanai T, Wada T*, Yamamoto T. Phylogenetic uniqueness of Mycobacterium avium subspecies hominissuis isolated from an abnormal pulmonary bovine case. Infect Genet Evol. 2018. 62:122–9. doi: 10.1016/j.meegid.2018.04.013.
動物の抗酸菌症
Ohkoshi Y, Sato T, Wada T, Fukushima Y, Murabayashi H, Takakuwa Y, Nishiyama K, Honda H, Shiraishi T, Kuronuma K, Takahashi H, Nakajima C, Suzuki Y, Yokota SI. Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection developing disseminated intravascular coagulation. J Infect Chemother. 2018. S1341-321X(18): 30031-X. doi: 10.1016/j.jiac.2018.01.012.
肺炎球菌
Yoshida H, Wada T, Taniyama D, Takahashi T. Draft genome sequence of clinical strain TANI1 of Streptococcus suis serotype 5 isolated from a bacteremia patient in Japan. Genome Announc. 2017. 5(18): e00260-17. doi: 10.1128/genomeA.00260-17.
連鎖球菌
Wada T, Hijikata M, Maeda S, Hang NTL, Thuong PH, Hoang NP, Hung NV, Keicho N. Complete genome sequence of a Mycobacterium tuberculosis strain belonging to the East African-Indian family in the Indo-Oceanic lineage, isolated in Hanoi, Vietnam. Genome Announc. 2017. 5(24): e00509-17. doi: 10.1128/genomeA.00509-17.
結核
Wada T, Hijikata M, Maeda S, Hang NTL, Thuong PH, Hoang NP, Hung NV, Keicho N. Complete genome sequences of three representative Mycobacterium tuberculosis Beijing family strains belonging to distinct genotype clusters in Hanoi, Vietnam, during 2007 to 2009. Genome Announc. 2017. 5(24): e00510-17. doi: 10.1128/genomeA.00510-17.
結核
Seto J, Wada T, Suzuki Y, Ikeda T, Mizuta K, Yamamoto T, Ahiko T. Mycobacterium tuberculosis transmission among elderly persons, Yamagata Prefecture, Japan, 2009–2015. Emerg Infect Dis. 2017. 23(3): 448–55. doi: 10.3201/eid2303.161571.
結核
Seto J, Wada T, Suzuki Y, Ikeda T, Mizuta K, Mitarai S, Ahiko T. Convenient PCR method for variable-number tandem-repeat typing of Mycobacterium tuberculosis clinical isolates. J Microbiol Methods 2017. 139: 12–4. doi: 10.1016/j.mimet.2017.04.008.
結核
Sato T, Ohkoshi Y, Wada T, Fukushima Y, Murabayashi H, Takakuwa Y, Nishiyama K, Shiraishi T, Nakajima C, Suzuki Y, Yokota SI. Complete Genome sequence of multidrug-resistant Streptococcus pneumoniae serotype 19F isolated from an invasive infection in Sapporo, Japan. Genome Announc. 2017. 5(44): e01239-17. doi: 10.1128/genomeA.01239-17.
肺炎球菌
Li WT, Chang HW, Pang VF, Wang FI, Liu CH, Chen TY, Guo JC, Wada T, Jeng CR. Mycolactone-producing Mycobacterium marinum infection in captive Hong Kong warty newts and pathological evidence of impaired host immune function. Dis Aquat Organ. 2017. 123(3): 239–49. doi: 10.3354/dao03092.
動物の抗酸菌症
Yokoyama K, Kubo K, Yoshida S, Wada T, Kawai T, Nishikomori R, Yoshida A. Tumor in chest wall caused by Mycobacterium bovis BCG infection: identification on polymerase chain reaction of formalin-fixed specimen. Pediatr Int. 2016. 58(4): 317–8. doi: 10.1111/ped.12894.
BCGワクチン
Ban E, Yoshida Y, Wakushima M, Wajima T, Hamabata T, Ichikawa N, Abe H, Horiguchi Y, Hara-Kudo Y, Kage-Nakadai E, Yamamoto T, Wada T*, Nishikawa Y. Characterization of unstable pEntYN10 from enterotoxigenic Escherichia coli (ETEC) O169:H41. Virulence 2015. 6(8): 735–44. doi: 10.1080/21505594.2015.1094606.
病原性大腸菌
Colins J, Ichikawa T, Abdu H, Ocheke I, Modise-Letsatsi D, Wada T, Okolo S, Yamamoto T. Maternal overweight/obesity characteristics and child anthropometric status in Jos, Nigeria. Niger Med J. 2015. 56(4): 236–9. doi: 10.4103/0300-1652.165031.
公衆衛生学
Okano Y, Yoshida S, Shinohara T, Takahashi N, Naito N, Kagawa K, Machida H, Hatakeyama N, Ohno A, Wada T, Ogushi F. Primary gingival tuberculosis diagnosed based on genetic identification. Intern Med. 2015. 54(21): 2765–8. doi: 10.2169/internalmedicine.54.4353.
結核
Seto J†, Wada T†*, Iwamoto T, Tamaru A, Maeda S, Yamamoto K, Hase A, Murakami K, Maeda E, Oishi A, Migita Y, Yamamoto T, Ahiko T. Phylogenetic assignment of Mycobacterium tuberculosis Beijing clinical isolates in Japan by maximum a posteriori estimation. Infect Genet Evol. 2015. 35: 82–8. doi: 10.1016/j.meegid.2015.07.029.
†Equal contribution
結核
Teramoto K, Suga M, Sato T, Wada T, Yamamoto A, Fujiwara A. Characterization of mycolic acids in total fatty acid methyl ester fractions from Mycobacterium species by high resolution MALDI-TOFMS. Mass Spectrometry 2015. 4: A0035. doi: 10.5702/massspectrometry.A0035.
結核
Wada T*, Iwamoto T, Tamaru A, Seto J, Ahiko T, Yamamoto K, Hase A, Maeda S, Yamamoto T. Clonality and micro-diversity of a nationwide spreading genotype of Mycobacterium tuberculosis in Japan. PLoS ONE 2015. 10(3): e0118495. doi: 10.1371/journal.pone.0118495.
結核
Wada T†, Maruyama F†, Iwamoto T, Maeda S, Yamamoto T, Nakagawa I, Yamamoto S, Ohara N. Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guerin (BCG) tuberculosis vaccine substrain Tokyo-172. Sci Rep. 2015. 5: 17827. doi: 10.1038/srep17827.
†Equal contribution
BCGワクチン
Yokoyama E, Hachisu Y, Iwamoto T, Nakanishi N, Arikawa K, Wada T, Seto J, Kishida K. Comparative analysis of Mycobacterium tuberculosis Beijing strains isolated in three remote areas of Japan. Infect Genet Evol. 2015. 34: 444–9. doi: 10.1016/j.meegid.2015.06.019.
結核
de Beer JL, Kodmon C, van Ingen J, Supply P, van Soolingen D, Global Network for Molecular Surveillance of Tuberculosis. Second worldwide proficiency study on variable number of tandem repeats typing of Mycobacterium tuberculosis complex. Int J Tuberc Lung Dis. 2014. 18(5): 594–600. doi: 10.5588/ijtld.13.0531.
結核
Haridy M, Tachikawa Y, Yoshida S, Tsuyuguchi K, Tomita M, Maeda S, Wada T, Ibi K, Sakai H, Yanai T. Mycobacterium marinum infection in Japanese forest green tree frogs (Rhacophorus arboreus). J Comp Pathol. 2014. 151(2–3): 277–89. doi: 10.1016/j.jcpa.2014.04.014.
動物の抗酸菌症
Umeda K, Hatakeyama R, Abe T, Takakura K, Wada T, Ogasawara J, Sanada S, Hase A. Distribution of Capnocytophaga canimorsus in dogs and cats with genetic characterization of isolates. Vet Microbiol. 2014. 171(1–2): 153–9. doi: 10.1016/j.vetmic.2014.03.023.
カプノサイトファーガ
Nakanishi N, Wada T, Arikawa K, Millet J, Rastogi N, Iwamoto T. Evolutionary robust SNPs reveal the misclassification of Mycobacterium tuberculosis Beijing family strains into sublineages. Infect Genet Evol. 2013. 16: 174–7. doi: 10.1016/j.meegid.2013.02.007.
結核
Tateishi Y, Tamaru A, Ogura Y, Niki M, Wada T, Yamamoto T, Hirata K, Hayashi T, Matsumoto S. Whole-genome sequence of the potentially hypertransmissible multidrug-resistant Mycobacterium tuberculosis Beijing Strain OM-V02_005. Genome Announc. 2013. 1(4): e00608-13. doi: 10.1128/genomeA.00608-13.
非結核性抗酸菌
瀬戸順次, 阿彦忠之, 和田崇之, 長谷篤, 山田敬子. 結核低蔓延地域における網羅的な結核菌反復配列多型(VNTR)分析の有用性.結核 2013. 88(6): 535–42.
結核
Umeda K, Wada T, Kohda T, Kozaki S. Multi-locus variable number tandem repeat analysis for Clostridium botulinum type B isolates in Japan: comparison with other isolates and genotyping methods. Infect Genet Evol. 2013. 16: 298–304. doi: 10.1016/j.meegid.2013.02.022.
ボツリヌス菌
Wada T, Maeda S. Multiplex agarose gel electrophoresis system for variable number of tandem repeats genotyping: analysis example using Mycobacterium tuberculosis. Electrophoresis 2013. 34(8): 1171–4. doi: 10.1002/elps.201200471.
結核
田丸亜貴, 和田崇之, 岩本朋忠, 長谷篤. JATA(12)-VNTR型別による結核集団発生事例の菌株異同調査. 結核 2013. 88(4): 399–403.
結核
和田崇之*, 田丸亜貴, 岩本朋忠, 有川健太郎, 中西典子, 小向潤, 松本健二, 長谷篤. 複数自治体をまたぐ広域的結核分子疫学の基盤構築 ―JATA(12)-VNTR型別に基づくクラスター形成とその傾向―. 結核 2013. 88(4): 393–8.
結核
de Beer JL, Kremer K, Kodmon C, Supply P, van Soolingen D, Global Network for the Molecular Surveillance of Tuberculosis. First worldwide proficiency study on variable-number tandem-repeat typing of Mycobacterium tuberculosis complex strains. J Clin Microbiol. 2012. 50(3): 662–9. doi: 10.1128/JCM.00607-11.
結核
Iwamoto T, Grandjean L, Arikawa K, Nakanishi N, Caviedes L, Coronel J, Sheen P, Wada T, Taype CA, Shaw MA, Moore DA, Gilman RH. Genetic diversity and transmission characteristics of Beijing family strains of Mycobacterium tuberculosis in Peru. PLoS ONE 2012. 7(11): e49651. doi: 10.1371/journal.pone.0049651.
結核
Tamaru A, Nakajima C, Wada T, Wang Y, Inoue M, Kawahara R, Maekura R, Ozeki Y, Ogura H, Kobayashi K, Suzuki Y, Matsumoto S. Dominant incidence of multidrug and extensively drug-resistant specific Mycobacterium tuberculosis clones in Osaka Prefecture, Japan. PLoS ONE 2012. 7(8): e42505. doi: 10.1371/journal.pone.0042505.
結核
Wada T*, Iwamoto T, Hase A, Maeda S. Scanning of genetic diversity of evolutionarily sequential Mycobacterium tuberculosis Beijing family strains based on genome wide analysis. Infect Genet Evol. 2012. 12(7): 1392–6. doi: 10.1016/j.meegid.2012.04.029.
結核
Maeda S, Wada T, Iwamoto T, Murase Y, Mitarai S, Sugawara I, Kato S. Beijing family Mycobacterium tuberculosis isolated from throughout Japan: phylogeny and genetic features. Int J Tuberc Lung Dis. 2010. 14(9): 1201–4.
結核
Kang HY, Wada T, Iwamoto T, Maeda S, Murase Y, Kato S, Kim HJ, Park YK. Phylogeographical particularity of the Mycobacterium tuberculosis Beijing family in South Korea based on international comparison with surrounding countries. J Med Microbiol. 2010. 59(10): 1191–7. doi: 10.1099/jmm.0.022103-0.
結核
Fujihara S, Arikawa K, Aota T, Tanaka H, Nakamura H, Wada T, Hase A, Nishikawa Y. Prevalence and properties of diarrheagenic Escherichia coli among healthy individuals in Osaka City, Japan. Jpn J Infect Dis. 2009. 62(4): 318–23. doi: 10.7883/yoken.JJID.2009.318.
病原性大腸菌
Iwamoto T, Fujiyama R, Yoshida S, Wada T, Shirai C, Kawakami Y. Population structure dynamics of Mycobacterium tuberculosis Beijing strains during past decades in Japan. J Clin Microbiol. 2009. 47(10): 3340–3. doi: 10.1128/JCM.01061-09.
結核
Wada T*, Fujihara S, Shimouchi A, Harada M, Ogura H, Matsumoto S, Hase A. High transmissibility of the modern Beijing Mycobacterium tuberculosis in homeless patients of Japan. Tuberculosis 2009. 89(4): 252–5. doi: 10.1016/j.tube.2009.05.007.
結核
Wada T*, Iwamoto T. Allelic diversity of variable number of tandem repeats provides phylogenetic clues regarding the Mycobacterium tuberculosis Beijing family. Infect Genet Evol. 2009. 9(5): 921–6. doi: 10.1016/j.meegid.2009.06.012.
結核
Wada T*, Iwamoto T, Maeda S. Genetic diversity of the Mycobacterium tuberculosis Beijing family in East Asia revealed through refined population structure analysis. FEMS Microbiol Lett. 2009. 291(1): 35–43. doi: 10.1111/j.1574-6968.2008.01431.x.
結核
Iwamoto T, Yoshida S, Suzuki K, Wada T. Population structure analysis of the Mycobacterium tuberculosis Beijing family indicates an association between certain sublineages and multidrug resistance. Antimicrob Agents Chemother. 2008. 52(10): 3805–9. doi: 10.1128/AAC.00579-08
結核
Wada T*, Maeda S, Hase A, Kobayashi K. Evaluation of variable numbers of tandem repeat as molecular epidemiological markers of Mycobacterium tuberculosis in Japan. J Med Microbiol. 2007. 56(8): 1052–7. doi: 10.1099/jmm.0.46990-0.
結核
Wada T, Maeda S, Tamaru A, Imai S, Hase A, Kobayashi K. Dual-probe assay for rapid detection of drug-resistant Mycobacterium tuberculosis by real-time PCR. J Clin Microbiol. 2004. 42(11): 5277–85. doi: 10.1128/JCM.42.11.5277-5285.2004.
結核
Aoki K, Matsumoto S, Hirayama Y, Wada T, Ozeki Y, Niki M, Domenech P, Umemori K, Yamamoto S, Mineda A, Matsumoto M, Kobayashi K. Extracellular mycobacterial DNA-binding protein 1 participates in mycobacterium- lung epithelial cell interaction through hyaluronic acid. J Biol Chem. 2004. 279(38): 39798–806. doi: 10.1074/jbc.M402677200.
結核
Nishikawa Y, Zhou Z, Hase A, Ogasawara J, Kitase T, Abe N, Nakamura H, Wada T, Ishii E, Haruki K, Surveillance T. Diarrheagenic Escherichia coli isolated from stools of sporadic cases of diarrheal illness in Osaka City, Japan between 1997 and 2000: prevalence of enteroaggregative E. coli heat-stable enterotoxin 1 gene-possessing E. coli. Jpn J Infect Dis. 2002. 55(6): 183–90.
病原性大腸菌
Sato K, Yomogida K, Wada T, Yorihuzi T, Nishimune Y, Hosokawa N, Nagata K. Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. J Biol Chem. 2002. 277(40): 37678–84. doi: 10.1074/jbc.M205347200.
分子生物学