Nanotechnology in Nose to Brain Drug Delivery

Project Synopsis:  

Scope: Novel dosage forms, Novel drug delivery system, Pharmaceutical Formulation

The worldwide predominance of neurologic disorders is rising, and however, we are still incapable to provide most of the drugs at therapeutic levels to the brain (Giunchedi et al., 2020). The blood-brain boundary comprises a tight layer of endothelial cells encompassed by astrocyte foot forms, and these anatomic highlights constitute a noteworthy boundary to drug transport from the blood to the brain (Bonferoni et al., 2019; Giunchedi et al., 2020). One way to bypass the blood-brain boundary and hence treat infections of the brain is to utilize the nasal route of administration and store drugs at the olfactory locale of the nares, from where they travel to the brain by means of components that are still not clearly caught on, with travel over nerve filaments and travel through a perivascular pathway both being hypothesized (Agrawal et al., 2018; Battaglia et al., 2018). The nose-to-brain course has been illustrated more than once in preclinical models, with both arrangement and particulate details (Nigam et al., 2019). The nose-to-brain course has to be illustrated in human considers with the arrangement and molecule definitions (Giunchedi et al., 2020; Wang et al., 2019). The application of nanotechnology in the dosage form could make this route of drug administration much more efficient and effective (Battaglia et al., 2018; Crowe et al., 2018; Nigam et al., 2019). The nanoparticle approach in the nose to brain drug delivery recently caught the attention of researchers worldwide and has massive potential to revolutionize the way we treat neurologic disorders such as Alzheimer’s and Parkinson’s disease currently.