PUBLICATION (~ 2018)

~2018 年

1. Wang L., Taniguchi Y.*, Okamura H. and Sasaki S.*
   Modification of the aminopyridine unit of 2'-deoxyaminopyridinyl-pseudocytidine allowing triplex formation at CG interruptionsin homopurine sequences,Nucleic Acids Res. 46(17) 8679-8688 (2018)DOI: https://doi.org/10.1093/nar/gky704 

2. Taniguchi Y.*, Miyazaki M., Matsueda N., Wang L., Okamura H. and Sasaki S.*
   Stable and Selective Antiparallel Type Triplex DNA Formation by Targeting a GC base pair with the TFO containing One N2-Phenyl-2'-deoxyguanosine,Chem. Pharm. Bull.66(6), 624-631 (2018)  DOI: https://doi.org/10.1248/cpb.c18-00043
   Highlighted paper selected by Editor-in-Chief

3. Wang L., Taniguchi Y.*, Okamura H. and Sasaki S.*
   Effect of the 3-halosubstitution of the 2'-deoxy aminopyridinyl-pseudocytidine derivatives on the selectivity and stability ofantiparallel triplex DNA with a CG inversion site,Bioorg. Med.Chem.,25(14), 3853-3860 (2017)  DOI: https://10.1016/j.bmc.2017.05.035

4. Taniguchi Y.*
   Development of damaged nucleoside mimics for inhibition of their repair enzymes,YAKUGAKU ZASSHI137(3), 293-300(2017)  DOI: http://doi.org/10.1248/yakushi.16-00231-2

5. Kawara K., Tsuji G., Taniguchi Y., Sasaki S.*
   Synchronized Chiral Induction Between [5] Helicene-Spermine Ligand and B-Z DNA transition,Chemistry - A EuropeanJournal.23(8), 1763-1769 (2017)  Doi: 10.1002/chem.201605276.

6. Okamura H,, Taniguchi Y.*, Sasaki S.*,
   Aminopyridinyl-pseudodeoxycytidine derivatives selectively stabilize antiparallel triplex DNA with multiple CG inversion sites.Angew. Chem. Int. Ed.55(40), 12445-12449 (2016)  DOI: 10.1002/anie201606136

7. Yin Y., Sasaki S., Taniguchi Y.*,
   Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNA polymerase and cell proliferation,Bioorg. Med. Chem. 24(16), 3856-3861 (2016)  doi: 10.1016/j.bmc.2016.06.030

8. Nishioka T., Oshiro I., Onizuka K., Taniguchi Y. and Sasaki S.*,
   Efficient thymidine-selective DNA interstrand photo-activecrosslinking by the 6-thioguanine connected via an ethylene-linkerto the 2'-deoxyribose unit,Chem. Pharm. Bull.64(9),1315-1320 (2016)  http://doi.org/10.1248/cpb.c16-00310

9. Koga Y., Taniguchi Y*, Kikukawa Y, Sasaki S*,
   Recognition and detection of 8-oxo-rG in RNA using the DNA/OMeRNA chimera probes containing fluorescent adenosine-diazaphenoxazine analogue,Bioorg. Med. Chem. 24(6), 1308-1313(2016)  doi: 10.1016/j.bmc.2016.02.001

10. Yin Y., Sasaki S., Taniguchi Y.*,
    Inhibitory Effect of 8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosineTriphosphatase, hMTH1, Actibities,ChemBioChem, 17(7) 566-569 (2016)  doi/10.1002/cbic.201500589.

11. Taniguchi Y*, Tomizaki A, Matsueda N, Okamura H, Sasaki S*,
    Enhancement of TFO Triplex Formation by Conjugation with Pyrene via Click Chemistry,Chem. Pharm. Bull.63 (11) 920-926. (2015)  http://doi.org/10.1248/cpb.c15-00570

12. Kikuta K. Haishun P. Brazier J. Taniguchi Y. Onizuka K. Nagatsugi F. Sasaki S*.
    Stabilization of the i-motif structure by theintrastrand cross-link formation,Bioorg. Med. Chem. Lett.25(16), 3307-3310(2015)  doi:10.1016/j.bmcl.2015.05.064

13. Oshiro I. Jitsuzaki D. Onizuka K. Nishimoto A. Taniguchi Y. and Sasaki S*.
    Site-specific modification of the 6-amino group of adenosine in RNA by an inter-strand functionality-transfer reaction using anS-functionalized-4-thiothymidine,ChemBioChem, 16(8), 1199-1204 (2015)  doi: 10.1002/cbic.201500084

14. Yin Y. Sasaki S. and Taniguchi Y*.
    Recognition and excision properties of 8-halogenated-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguaanosine analogues andFPG and hOGG1 inhibitors,ChemBioChem, 16(8), 1190-1198 (2015)  doi: 10.1002/cbic.201402690

15. Taniguchi Y*., Kikukawa Y and Sasaki S*.
    Discrimination Between 8-Oxo-2'-Deoxyguanosine and 2'-Deoxyguanosine in  DNA by the Single Nucleotide PrimerExtension Reaction with Adap Triphosphate,Angew. Chem. Int. Ed.54(17), 5147-5151(2015)  doi: 10.102/anie.201412086.

16. Okamura H., Taniguchi Y*. and Sasaki S*.
    An Isocytidine Derivative with a 2-Amino-6-methylpyridine Unit for Selective Recognition of the CG Interrupting Site in anAntiparallel Triplex DNA,ChemBioChem.15(16), 2374-2378 (2014)  doi: 10.1002/cbic.201402328,.

17. Jitsuzaki D., Onizuka K., Nishimoto A., Oshiro I., Taniguchi Y. and Sasaki S*.
    Remarkable acceleration of the DNA/RNA inter-strand functionality-transfer reaction to modify a cytosine residue: theproximity effect via complexation with a metalcation,Nucleic Acids Res.,42(13), 8808-8815 (2014)  doi: 10.1093/nar/gku538.

18. Yamada Y. Tabata M., Yasuzaki Y., Nomura M., Shibata A., Ibayashi Y., Taniguchi Y., Sasaki S. and Harashima H.
    Ananocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line,Biomaterials, 35(24), 6430-6438(2014)  DOI: 10.1016/j.biomaterials.2014.04.017

19. Goto T., Shiina A., Murata T., Tomii M., YamazakiT., Yoshida K., Yoshino T., Suzuki O., Sogawa Y., Mizukami K., TakagiN.,Yoshitomi T., Etori M., Tsuchida H., Mikkaichi T., Nakao N., Takahashi M., Takahashi H, Sasaki S.
    Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highlyselective PDE4B inhibitors,Bioorg. Med. Chem.Lett., 24(3), 893-899 (2014)  DOi: 10.1016/j.bmcl.2013.12.076

20. Yizhen Y., Taniguchi Y.* and Sasaki S.*,
    Synthesis of 8-halogenated-7-deaza-2'-deoxyguanosine as an8-oxo-2'-deoxyguanosine analogue and evaluation of its basepairing properties.Tetrahedron, 70(11), 2040-2047 (2014)  doi: 10.1016/j.tet.2014.01.047.

21. Taniguchi Y.*, Fukabori K., Kikukawa Y., Koga Y and Sasaki S.*,
    2,6-Diaminopurine nucleoside derivative of 9-ethyloxy-2-oxo-1,3-diazaphenoxazine(2-amino-Adap) for recognition of 8-oxo-dGin DNA.  Bioorg. Med. Chem. 22(5), 1634-1641 (2014)  DOI:http://dx.doi.org/10.1016/j.bmc.2014.01.024

22. Taniguchi Y., Koga Y., Shigeki Sasaki*. Synthesis of 8-oxoguanosine phosphoramidite and its incorporation intooligoribonucleotides.Current Protocols in Nucleic Acid Chemistry, UNIT4.58 56:4.58.1-4.58.10  DOI:10.1002/0471142700.nc0458s56

23. Sasaki H. and Sasaki S*.
    B-Z Transition of (dA-T)n Duplex Induced by Spermine Porphyrin-Conjugate via anIntermediateDNA Conformation.Chem.Comm.,49(79) 9024-9026(2013)  DOI: 10.1039/C3CC45213A

24. Okamura H, Taniguchi Y* and Sasaki S*.
    N-(Guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits a selective recognition ofa CG interrupting site for the formation ofanti-parallel triplexes,Org. Biomol. Chem., 11. 3918-3924 (2013)  DOI: 10.1039/C3OB40472B

25. Nishimoto A., Jitsuzaki D., Onizuka K., Taniguchi Y., Nagatsugi F. and Sasaki S*.
    4-Vinyl-Substituted PyrimidineNucleosides Exhibit the Efficient and SelectiveFormation of Interstrand Cross-Links with RNAand duplex DNA,NucleicAcids Res.,41(13) 6774-6781 (2013)  DOI: 10.1093/nar/gkt197

26. Koga Y., Taniguchi Y and Sasaki S*.
    Synthesis of the Oligoribonucleotides Incorporating 8-Oxo-guanosine and Evaluation oftheir Base Pairing Properties,  Nucleosides, Nucleotides and Nucleic Acids, 32(3), 124-136. (2013)  DOI: 10.1080/15257770.2013.767461

27. Taniguchi Y., Okamura H., Fujino N., Sasaki S*.
    Synthesis of 1'-phenyl-2-OMe ribose analogues connecting the thyminebase at the 1' position through a flexible linker for theformation of a stable anti-parallele triplex DNA,Tetrahedron, 69(2), 600-606 (2013)  DOI: 10.1016/j.tet.2012.11.016 

28. Nasr T, Taniguchi Y., Takaki T., Okamura H., Sasaki S*.
    Properties of Oligonucleotidewith Phenyl-Substituted CarbocyclicNucleoside Analogues for the Formation ofDuplex andTriplex DNA,Nucleosides, Nucleotides and Nucleic Acids,31(12),8441-860. (2012)DOI: 10.1080/15257770.2012.737970.

29. Taniguchi Y* and Sasaki S*.,
    An efficient antigene activity and antiproliferative effect by targeting the Bcl-2 or survivin genewith triplex formingoligonucleotides containing a W-shaped nucleoside analogue (WNA-bT),Org. Biomol. Chem., 10(41),8336-8341. (2012)DOI: 10.1039/c2ob26431e

30. Aoki E., Taniguchi Y., Wada Y., Sasaki S*,
    Efficient DNA strand displacement by a W-shaped nucleoside analogue (WNA-bT) containing an ortho-methyl-substitutedphenyl ring,ChemBioChem,. 13(8), 1152-1160 (2012)DOI: 10.1002/cbic.201200066

31. Onizuka K., Nishioka T., Li Z., Jitsuzaki D., Taniguchi Y. and Sasaki S.*,
    Aneficient and simple method for site-selectivemodification of O6-methyl-2'-deoxyguanosine in DNA,,Chem. Comm.,48 (33),3969-3971.DOI: 10.1039/c2cc17621a

32. Sasaki S.*, Onizuka K., Taniguchi Y.,
    Oligonucleotide containing S-Functionalized 2'-deoxy-6-thioguanosine: Facile Toolsfor Base-Selective and Site SpecificInternal Modification of RNA,Current Protocols in Nucleic Acid Chemistry, 4.49.1-4.49.16 (2012)DOI: 10.1002/0471142700.nc0449s.48

33. Taniguchi Y, Koga Y, Fukabori K, Kawaguchi R, Sasaki S.*,
    OFF-to-ON type fluorescent probe for the detection of 8-oxo-dGin DNA by the Adap-masked ODN probe,Bioorg. Med.Chem. Lett., 22(1), 543-546 (2012)DOI: 10.1016/j.bmcl.2011.10.093.

34. Sasaki S., Onizuka K. and Taniguchi Y,
    The oligodeoxynucleotide probes for the site-specific modification of RNA,Chem.Soc. Rev.,40(12), 5698-5706 (2011)DOI: 10.1039/c1cs15066a.

35. Taniguchi Y, Kawaguchi R, Sasaki S.,
    Adenosine-1,3-diazaphenoxazine Derivative for Selective Base Pair Formation with 8-Oxo-2'-deoxyguanosine in DNA,J. Am.Chem. Soc., 133, 7272-7275 (2011).DOI: 10.1021/ja200327u.

36. Onizuka K, Shibata A, Taniguchi Y, Sasaki S.,
    Pin-Point Chemical Modification of RNA with DiverseMolecules through theFunctionality Transfer Reaction and Copper-CatalyzedAzide-Alkyne Cycloaddition Reaction,Chem. Comm.,47(17), 5004-5006 (2011).DOI: 10.10389/C1CC10582E,

37. Taniguchi Y., Nitta A., Park S. M., Kohara A., Uzu T., Sasaki S., The ODN probes conjugating the Cu(II) complexenhancethe luminol chemiluminescense by assembling on the DNA template,Bioorg. Med. Chem.18, 8614-8617 (2010).

38. Doi I., Tsuji G., Kawakami K., Nakagawa O., Taniguchi Y., Sasaki S., The Spermine-Bisaryl Conjugate as a PotentInducerfor the B to Z-DNA Transition,Chem. Eur. J.16, 11993-11999 (2010).

39. Imoto S., Hori T., Hagihara, S., Taniguchi Y., Sasaki S., Nagatsugi F., Alteration of Cross-linking Selectivity with the 2'-OMeAnalogue of 2-Amino-6-Vinylpurine and Evaluation of Antisense EffectBioorg. Med. Chem. Lett., 20, 6121-6124 (2010).

40. Onizuka K., Taniguchi Y., Sasaki S., Activation and Alteration of Base Selectivity by Metal Cations in the Functionality-Transfer Reaction for RNA Modification,Bioconjugate Chem.21, 1508-1512 (2010).

41. Li Z, Nakagawa O, Koga Y, Taniguchi Y., Sasaki S., Synthesis of New Derivatives of 8-oxoG-Clamp for BetterUnderstandingthe Recognition Mode and Improvement of Selective AffinityBioorg. Med. Chem.18, 3992-3998 (2010).

42. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S.,  The Alkyl-Connected 2-Amino-6-Vinylpurine (AVP)Crosslinking Agent for Improved Selectivity to the Cytosine,Bioorg. Med. Chem.,18. 2894-2901 (2010).

43. Onizuka K, Taniguchi Y., Sasaki S., A New Usage of Functionalized Oligodeoxynucleotide Probe for Site-SpecificModification of a Guanine Base within RNA,Nucleic Acids Res.38, 1760-1766 (2010).

44. Taniguchi Y., Uchida Y., Takaki T., Aoki E., Sasaki S., Recognition of CG interrupting site by W-shaped nucleoside analogs(WNA) having the pyrazole ring in an anti-parallel triplex DNA,Bioorg. Med. Chem.17, 6803-6810 (2009).

45. Onizuka K.,Taniguchi Y., Nishioka T., Sasaki S., Site-specific modification of RNA by functionality-transfer ODNprobes,NucleicAcids Symp. Ser.,53, 67-68 (2009).

46. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S., Evaluation of theantisense effectofPEGylatedoligodeoxynucleotidescontaining intelligent nucleoside analogues,Nucleic Acids Symp. Ser., 53,167-168 (2009).

47. Onizuka K, Taniguchi Y., Sasaki S., A New Odorless Procedure for the synthesis of 2'deoxy-6-thioguanosine andItIncorporation Into Oligonucleotides,Nucleosides, Nucleotides, and Nucleic Acids, 28, 752-760 (2009).

48. Onizuka K, Taniguchi Y., Sasaki S., Site-specific covalent modification of nucleic acids guided by functionality-transferoligodeoxynucleotidesBioconjugate Chem.20, 799-803 (2009).

49. Nasr T., Li Z., Nakagawa O., Taniguchi Y., Ono S., Sasaki S., Selective Fluorescence Quenching of the 8-OxoG-clamp by 8-Oxodeoxyguanosine in ODN,Bioorg. Med. Chem. Lett.,19, 727-730 (2009).

50. Onizuka K, Taniguchi Y., Nishioka T., Sasaki S., Site-specific modification by functionality-transfer oligonucleotide withthephoto-inducible reactivity.Nucleic Acids Symp. Ser., 52, 367-368 (2008)

51. Kurose Y., Taniguchi, Y., Nagatsugi F., Sasaki S., Synthesis of new nucleosides analogue connecting 2-amino-6-vinylpurineto the 2’-deoxyribose skeletonviathe methylene linker.Nucleic Acids Symp., Ser.52, 43-44 (2008).

52. Uchida Y., Taniguchi Y., Aoki E., Togo M., Sasaki S., Formation of a stable triplex incorporating a CG interrupting site byanew WNA derivative containing 3-aminopyrazole as a nucleobase.Nucleic Acids Symp. Ser., 52, 137-138 (2008).

53. Brazier, J. A., Onishi I., Sasaki S., Binding of two bis-bipyridine minor groove binders to a DNA template in the presenceofCu2+ione.Nucleic Acids Symp. Ser., 52, 107-108 (2008).

54. Taniguchi Y., Togo M., Aoki E., Uchida Y., Sasaki S., Synthesis of p-amino-WNA derivatives to enhance the stability oftheanti-parallel triplex,Tetrahedron,64,7164-7170 (2008).

55. Nasr T., Taniguchi Y., Sasaki S., Synthesis of 1’-Phenyl Substituted Nucleoside Analogs,Heterocycles,73, 2659-2668 (2007).

56. Onizuka K., Taniguchi Y., Sasaki S., Development of novel thioguanosine analogs with the ability to specificallymodifycytidine,Nucleic Acids Symp. Ser.,51, 5-6 (2007).

57. Aoki E., Taniguchi Y., Sasaki S., Effective strand invasion ODN incorporating a new bicyclic nucleoside analogue (WNA),Nucleic Acids Symp. Ser.,51, 255-256 (2007).

58. Taniguchi Y., Kool E. T., Syntheses and properties of low-polarity shape mimics of 8oxopurines,Nucleic Acids Symp. Ser.,51, 217-218 (2007).

59. Taniguchi Y., Kool E. T., Nonpolar Isosteres of Damaged DNA Bases: Effective Mimicry of Mutagenic Properties of 8-Oxopurines,J. Am. Chem. Soc.,129, 8836-8844 (2007).

60. Uzu T., Sasaki S., A New Copper(II) Complex as an Efficient Catalyst of Luminol Chemiluminescence,Organic Lett.,9, 4383-4386 (2007).

61. Alam Md., Majumdar A., Thazhathveetil A., Liu S.-T., Liu J.-Lan., Puri N., Cuenoud B., Sasaki S., Miller P., Seidman M.,Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo,Biochemistry,46, 10222-10233 (2007).

62. Aoki E., Taniguchi Y., Togo M., Sasaki S., Effects of the modified aromatic ring of WNA on stability of triplex DNA,NucleicAcids Symp. Ser.,50, 185-186 (2006).

63. Taniguchi Y., Nakamura A., Senko Y., Nagatsugi F., Sasaki S., Effects of Halogenated WNA Derivatives onSequenceDependency for Expansion of Recognition Sequences in the Non-Natural Type Triplexes,J. Org. Chem.,71, 2115-2122(2006).

64. Taniguchi Y., Nakamura A., Senko Y., Kodama K., Nagatsugi F., Sasaki S., Expansion of triplex recognition codes bytheuse of novel bicyclic nucleoside derivatives (WNA),Nucleosides, Nucleotides, and Nucleic Acids,24, 823-827 (2005).

65. Taniguchi Y., Nakamura A., Aoki E., Sasaki S., Modification of the aromatic ring of the WNA analogues for expansion ofthetriplex recognition codes,Nucleic Acids, Symp. Ser.,49, 173-174 (2005).

66. Taniguchi Y., Nakamura A., Senko Y., Sasaki S., Effects of 5-substituted pyrimidine nucleoside bases of WNA on stabilityoftriplex DNA,Nucleic Acids, Symp. Ser.,48, 69-70 (2004).

67. Sasaki S., Taniguchi Y., Takahashi R., Senko Y., Kodama K., Nagatsugi F., Maeda M., Selective Formation ofStableTriplexes Including a TA or a CG Interrupting Site with New Bicyclic Nucleoside Analogues (WNA),J. Am. Chem. Soc.,126,516-528 (2004).

68. Taniguchi Y., Senko Y., Kodama K., Nakamura A., Sasaki S., Design and evaluation of novel nucleoside analogs (WNA)forspecific formation of non-natural type triplexes containing a TA or CG interrupting site.,Nucleic Acids Res. Suppl.,3, 113-114 (2003).

69. Yosuke Taniguchi, Ryo Takahashi, Keiichi Kodama, Yusuke Senko, Minoru Maeda and Shigeki Sasaki, Selectiveformationof non-natural type triplexes containing TA interrupting sites with the TFO incorporating W-shape nucleic acid (WNA)analogs,Nucleic Acids Res. Suppl.,2, 34-35 (2002).

70. Shigeki Sasaki, Hiroyuki Yamauchi, Fumi Nagatsugi, Ryo Takahashi, Yosuke Taniguchi and Minoru Maeda, W-shapenucleic acid (WNA) for selective formation of non-natural anti-parallel triplex including a TA interrupting site,TetrahedronLett.,426915-6918 (2001).

71. S,Sasaki, H. Yamauchi, R. Takahashi, Y. Taniguchi M. Maeda, New base analogs for the formation of non-natural triplexes,Nucleic Acids Res. Suppl.1, 23-24 (2001).