PUBLICATION

~ 2018 年のはこちら

2025 年     

1. Eto M., Murase H.,* Lee J., Taniguchi Y., Imoto S. and Sasaki S.
   Sequence-selective 2'-O-acetyl modification of RNA mediated by duplex formation with a reactive oligonucleotide probe incorporating 4-thio-dT
   Chem. Pharm. Bull. 73 (2025) in press.

2. Miyahara R. and Taniguchi Y.*
   Synthesis of a Pseudocytidine Nucleoside to Form a Stable and Selective Base Pair with Iso-guanosine in RNA
   Organic Lett. 27 (35) 9749-9752 (2025) https://doi.org/10.1021/acs.orglett.5c03060

3. Anada T.,* Kawahara M., Shimada T., Kuroda R., Okamura H., Setoyama D., Nagatsugi F., Kunisaki Y., Kage-Nakadai E., Kobayashi S. and Tanaka M.*
   A Nucleic Acid Prodrug That Activates Mitochondrial Respiration, Promotes Stress Resilience, and Prolongs Lifespan
   J. Am. Chem. Soc. 147 (25) 22161-22175 (2025) https://doi.org/10.1021/jacs.5c06772 

4. Takasaki H., Kitazaki K., Hadano Y., Murase H., Lee J., Taniguchi Y., Sasaki S.*
   New Nucleoside Derivatives for Hybridization-Assisted Catalysis of Site-Selective Acetylation of 2′-OH of RNA
   Chem. Pharm. Bull. 73 (5), 457–466 (2025) https://doi.org/10.1248/cpb.c25-00068 

5. Wang L.,* Ji D., Liu X., Lei W., Taniguchi Y. and Ling Y.* 

Recent progress of triplex DNA formation and its applications

J. Med. Chem., 68 (5), 5055–5074 (2025)  https://doi.org/10.1021/acs.jmedchem.4c02518 

6. Miyahara R. and Taniguchi Y.*

Synthesis of oligodeoxynucleotide containing pseudo-deoxycytidine and its triphosphate derivative

Curr. Protoc. 5 (3), e70101 (2025) https://doi.org/10.1002/cpz1.70101    

2024 年

1. Murase H.,* Eto M., Lee J., Taniguchi Y., Imoto S. and Sasaki S.
   Site-specific acetyl modification of 20-OH of RNA by an oligonucleotide acetylating reagent      
   Chem. Commun, (2024) DOI: 10.1039/d4cc04672b  

2. Aso M.,* Ohta C., Liu Y., Sasaki-Tabata K., Abe-Sadamatsu Y., Gatanaga C., Wang Y., Pei Y., Gao G., Katayama T., Taniguchi Y. and Sasaki S.
   Design and synthesis of an environment-sensitive 3-methylene-isoindolin-1-one fluorophore for labeling DNA-interacting proteins     
   Org. Biomol. Chem., 22(35), 7231-7339 (2024). DOI: 10.1039/d4ob01036a 

3. Murase H., Lee J., Togo N., Taniguchi Y. and Sasaki S.*
   The Selective chemical modification of the 6-amino group of adenosine of the premature termination codon induces readthrough to produce full-length peptide in the reconstituted E. coli translation system
   Bioorg. Med. Chem.,111, 117868 (2024) https://doi.org/10.1016/j.bmc.2024.117868

4. Notomi R., Sasaki S. and Taniguchi Y.*
   Novel strategy for activating gene expression through triplex DNA formation targeting epigenetically suppressed genes
   RSC Chem. Biol., 9(5) 884-890 (2024) https://doi.org/10.1039/D4CB00134F 

5. Wang L.*, Wang D., Lei W., Sun T., Gu B., Dong H., Taniguchi Y., Liu Y. and Ling Y.
   Trigonometric Bundling Disulfide Unit Starship Synergizes More Effectively to Promote Cellular Uptake
   Int. J. Mol. Sci., 25(14), 7518 (2024) DOI: https://doi.org/10.3390/ijms25147518  

6. Sakurada T., Chikada Y., Miyahara R. and Taniguchi Y.*
   Recognition of 8-Oxo-2’-deoxyguanosine in DNA using the Triphosphate of 2’-Deoxycytidine Connecting the 1,3-Diazaphenoxazine Unit, dCdapTP
   Molecules, 29(10), 2270 (2024)  doi.org/10.3390/molecules29102270

7. Tomimatsu K., Fujii T., Bise R., Taniguchi Y., Ochiai H., Ohishi H., Ando K., Minami R., Tanaka K., Tachibana T., Mori S., Harada A., Maehara K., Nagasaki M., Uchida S., Kimura H., Narita M. and Ohkawa Y.
   Precise immunofluorescence canceling for highly multiplexed imaging to capture specific cell states
   Nature Commun, 8;15(1): 3657 (2024)  DOI：10.1038/s41467-024-47989-9 

8. Wang L.*, Ling Y., Tian Y., Wang X., Sasaki S. and Taniguchi Y.*
   The Development of Non-natural Type Nucleoside to Stabilize Triplex DNA Formation against CG and TA Inversion Site
   Curr. Med. Chem. 31 (19), 2663-2686 (2024) DOI: 10.2174/0929867330666230512114130 

9. Ito A., Wang L., Notomi R., Sasaki S. and Taniguchi Y.*
   Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site

Chem. Pharm. Bull. 72(1), 16-20 (2024) DOI: https://doi.org/10.1248/cpb.c23-00666 

2023 年

1. Wang L., Notomi R., Sasaki S. and Taniguchi Y.*

Inhibition of transcription and antiproliferative effects in a cancer cell line using antigene oligonucleotides containing artificial nucleoside analogues

RSC. Med. Chem. 14 (8), 1482-1491 (2023) DOI: https://doi.org/10.1039/D3MD00139C

2. Notomi R., Sasaki S and Taniguchi Y.*

Post-synthetic modification of triplex-forming oligonucleotides containing 2-aminoethyl-2'-deoxynebularine derivatives

Curr. Protoc. 3 (10), e893 (2023) DOI: 10.1002/cpz1.893

3. Murase H, Lee J., Taniguchi Y., Sasaki S.*

Site-specific tritium labeling at the predefined internal position of the chemically-modified RNA

Chem. Pharm. Bull. 71 (1), 64-69 (2023) DOI: https://doi.org/10.1248/cpb.c22-00738 

2022 年

1. Notomi R., Sasaki S. and Taniguchi Y.*,
   Recognition of 5-Methyl-CG and CG Base Pairs in Duplex DNA with High Stability using Antiparallel-type Triplex-forming Oligonucleotides with 2-Guanidinoethyl-2'-deoxy-nebularine,
   Nucleic Acids Res., 50 (21) 12071-12081 (2022). DOI: https://doi.org/10.1093/nar/gkac1110 

2. Miyahara R. and Taniguchi Y.*
   Selective Unnatural Base Pairing and Recognition of 2-Hydroxy-2'-deoxyadenosine in DNA by Pseudo-dC Derivatives,
   J. Am. Chem. Soc.144 (35) 16150-16156 (2022)  DOI: https://doi.org/10.1021/jacs.2c07000

3. Wu J., Zhang M., Song L., Tan Y., Taniguchi Y., Hipolito C. J., Zhang Y. and Yin Y.*
   Implications of N7-hydrogen and C8-keto on the base pairing, mutagenic potential and repair of 8-oxo-2'-deoxy-adenosine:Investigation by nucleotide analogues,
   Bioorg. Chem.127, 106029 (2022) DOI:https://doi.org/10.1016/j.bioorg.2022.106029

4. Togo N., Murase H., Lee J., Taniguchi Y. and Sasaki S.*
   Application of the Functionality Transfer Oligonucleotide for the Site-Selective Modification of RNA with a Divers Molecule,
   Chem. Pharm. Bull.70 (7), 498-504 (2022) DOI:https://doi.org/10.1248/cpb.c22-00288

5. Kikukawa Y., Kawazoe R., Miyahara R., Sakurada T., Nagata Y., Sasaki S. and Taniguchi Y.*
   Multiple-turnover single nucleotide primer extension reactions to detect of 8-oxo-2'-deoxyguanosine, 
   ChemComm.58 (35), 5399-5402 (2022) DOI: 10.1039/d2cc01372j

6. Taniguchi Y.*
   Development of Artificial Nucleoside Analogues for the Recognition and Detection of Damaged Nucleoside in DNA,
   J. Syn. Org. Chem.80 (1), 46-54 (2022) DOI: https://doi.org/10.5059/yukigoseikyokaishi.80.46

7. Yamauchi K., Matsuoka Y., Takahashi M., Yoshihiro N., Taniguchi Y., Kawai K., Bamba T. and Yamada K.*
   Detection and Structural Analysis of Pyrimidine-Derivatived Radicals Generated on DNA using a Profluorescent NitroxideProbe,
   ChemComm.58 (1), 56-59 (2022) Doi:https://doi.org/10.1039/D1CC04998D 

2021 年

1. Sakurada T., Miyahara R., Kawazoe R., Nagata Y., Kikukawa Y., Sasaki S. and  Taniguchi Y.*
   Simple and easy synthesis of g-amido-dNTPs in water and their polymerase reaction properties, 
   Chem. Pharm. Bull.69(11), 1061-1066 (2021)Doi: https://doi.org/10.1248/cpb.c21-00497 

2. Notomi R., Wang L., Sasaki S. and  Taniguchi Y.*
   Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA withduplex DNAbearing the5mCG base pair,
   RSC Adv. 11,21390-21396 (2021)Doi: 10.1039/D1RA02831F

3. Shi H., Ishikawa R., Heh C.H., Sasaki S. and  Taniguchi Y.*
   Development of MTH1-binding nucleotide analogs based on 7,8-dihalogenated 7-deaza-dG derivatives,
   Int. J. Mol. Sci. 22(3),1274 (2021)  Doi: org/10.3390/ijms22031274

2020 年

1. Notomi R., Wang L., Osuki T., Okamura H., Sasaki S.* and  Taniguchi Y.*
   Synthesis of C-nucleoside analogues based on the pyrimidine skeleton for the formation of anti-parallel-type triplex DNA witha CG mismatch site,
   Bioorg. Med. Chem.28(23), 115782 (2020)https://doi.org/10.1016/j.bmc.2020.115782

2. Kikuta K., Barta J., Taniguchi Y. and Sasaki S.*
   Synthesis of Nucleotide Derivatives of N-Acyl-7-Nitroindoline, their Incorporation into the DNA Oligomer, and Evaluation ofTheir Photoreactivity in the DNA/RNA duplex,
   Chem. Pharm. Bull.68(12), 1210-1219 (2020)https://doi.org/10.1248/cpb.c20-00594

3. Wang L., Okamura H., Sasaki S.* and Taniguchi Y.*
   Enhancements in the Utilization of Antigene Oligonucleotides in the Nucleus by Booster Oligonucleotides,
   ChemComm., 56(67), 9731-9734 (2020) https://doi.org/10.1039/D0CC04240D　

4. Taniguchi Y.*, Magata Y., Osuki T., Notomi R., Wang L., Okamura H. and Sasaki S.*
   Development of novel C-nucleoside analogues for formation of antiparallel-type triplex DNA with DNA that includes TA and dUAbase pairs
   Org. Biomol. Chem.,18 (15), 2845-2851 (2020) https://doi.org/10.1039/D0OB00420K

5. Aoki Y.*,Taniguchi Y., Matsumoto M., Matsumoto M., Ohno M., Masumura K., Sasaki S., Tsuzuki T., Yamamoto M.,Nohmi T.
   Oxidative stress driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassiumbromate,
   Mutation Research - Genetic Toxicology and Environmental Mutagenesis. (Mutat Res Gen Tox En)  850-851, 503136(p1-9) (2020)  https://doi.org/10.1016/j.mrgentox.2020.503136

2019 年

1. Taniguchi Y.*, Cao X., Sasaki S.*
   Synthesis of  the deuterated thymidine-d9 and deuterated oligonucleotides,
   Tetrahedron Letters.60(38) 151037-151039 (2019)  DOI:https://doi.org/10.1016/j.tetlet.2019.151037

2. Taniguchi Y.*, Sagara I., Nagata Y., Kikukawa Y., Sasaki S.*
   Effect of the 2-substituted adenosine-1,3-diazaphenoxazine 5'-triphosphate derivatives on the single primer extension reaction by DNA polymerase,
   Chem. Pharm. Bull.67(10), 1123-1130 (2019)DOI:https://doi.org/10.1248/cpb.c19-00453

3. Kikuta K., Taniguchi Y., Sasaki S.*
   Study of the inducible cross-linking reaction to mRNA and the effect on the translation,
   Chem. Pharm. Bull.67(8), 877-883  (2019)DOI:https://doi.org/10.1248/cpb.c19-00337

4. Thavoncharoensub N., Maruyama K., Heh C.H., Leong K.H., Shi H., Shigematsu Y., Sasaki S. and Taniguchi Y.*
   Synthesis of g-N-modified 8-oxo-2'-deoxyguanosine triphosphate and its characterization,
   Nucleosides, Nucleotides and Nucleic Acids.38(8), 578-589 (2019)　https://doi.org/10.1080/15257770.2019.1586919　

5. Taniguchi Y.*, Wang L., Okamura H. and Sasaki S.*
   Synthesis of 2'-deoxy-4-aminopyridinylpseudocytidine derivatives for incorporation into triplex forming oligonucleotides,
   Current Protocoles in Nucleic Acids Chemistry.  77(1), e80 (2019)DOI: https://doi.org/10.1002/cpnc.80