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METABOLOMICS:
Metabolomics is rightly called ‘the next generation of biochemistry’. The importance of metabolism has been long described, which consists of more than 3000 metabolic genes organized in pathways interconnected by 1000s of metabolites. These metabolites form the backbone of multiple anabolic and catabolic processes and the study of the flux has always been challenging due to its dynamic nature and the limit of current technologies to study metabolic flux.
The metabolite composition is central to every living organism, and in-depth metabolite analysis can open up numerous opportunities across a variety of areas. It remains poorly understood how these metabolites are rewired during various metabolic stresses. One of the primary reasons for metabolic stress is the availability/non-availability of vasculature near cells under pathological conditions like cancer and other vascular diseases. We are also interested in studying the ‘metabolic reprogramming’ and ‘metabolic cross-talk’ that occurs during cancer between tumor and stromal cells.
Reference : Kumar S et al, Cell Metabolism (2019); Grunewald M , Kumar S et al, Science (2021)
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