Signal Transduction Lab

Javier García Nafría

email: jgarcianafria@unizar.es

ORCID Google Scholar

ResearchGate


Our group is part of the NEUROMOL DGA group.

Selected publications

Molecular determinants of β-arrestin coupling to formoterol-bound β1-adrenoceptor.Lee Y., Warne T., Nehme R., Pandey S., Chaturvedi M., Dwivedi-Agnihotri H., Edwards P., García-Nafría J., Leslie A., Shukla AK., Tate CG.Nature. 2020 Jun 17. doi: 10.1038/s41586-020-2419-1.
Cryo-Electron Microscopy: Moving Beyond X-ray Crystal Structures for Drug receptors and Drug development. (2019) García-Nafría J. and Tate CG. Annual Reviews in Pharmacology and Toxicology. 2020 Jan 6;60:51-71. doi: 10.1146/annurev-pharmtox-010919-023545.
Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8. (2019)Herguedas B, Watson JF, Ho H, Cais O, García-Nafría J, Greger IH.Science. 2019 Mar 14. pii: eaav9011
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.(2018)García-Nafría J., Nehme R., Edwards P., Tate CG.Nature, 2018. 558 (7711). 620-62
Structure and organization of heteromeric AMPA-type glutamate receptors. (2016)Herguedas B*, García-Nafria J*, Cais O, Fernandez-Leiro R, Ho H, Krieger J, Greger IH. Science. 2016. Apr 29;352(6285):aad3873
IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly. (2016)García-Nafria J, Watson JF, Greger IH. Scientific Reports.. 2016 Jun 6;6:27459.

News


17 January 2021

Grateful to get a Instruct Pilot Study Award! We are happy to get seed funding to try high risk/high gain ideas!


21 December 2020

Our review is featured in The atlas of science: https://atlasofscience.org/cryo-electron-microscopy-in-drug-development/


16 October 2020

Congratulations to Iris del Val García for obtaining the undergrad research fellowship "beca de colaboración" to work in the lab. Exciting moments ahead!!


09 October 2020

We are grateful to the BBVA Leonardo Fundation for the Beca Leonardo a Investigadores y Creadores Culturales 2020. We will do our best!


24 September 2020

Welcome Sandra Arroyo Urea, who joins the team as a PhD student!


17 June 2020

The arrestin work gets highlighted in the TV news, newspapers and radio.


17th June 2020

Very happy to share the latest work on arrestin-complex with b1AR in a nanodisc, a great effort from Yang Lee!! See here.


25th February 2020

Great collaboration with Silvia Hernández Ainsa on creating DNA origami resembling clathrin molecules to stabilize lipid vesicles. See here.

18th October 2019

Our review about DNA assembly using in vivo bacterial recombination is out! See here.

10th September 2019

Opening day for the lab!!