Signal Transduction Lab

Javier García Nafría

email: jgarcianafria@

ORCID Google Scholar


Selected publications

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8. (2019)Herguedas B, Watson JF, Ho H, Cais O, García-Nafría J, Greger IH.Science. Mar 14. pii: eaav9011
Cryo-Electron Microscopy: Moving Beyond X-ray Crystal Structures for Drug receptors and Drug development. (2019) García-Nafría J. and Tate CG. Annual Reviews in Pharmacology and Toxicology. 2020. In press (2019 Jul 26. doi: 10.1146.)
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.(2018)García-Nafría J., Nehme R., Edwards P., Tate CG.Nature, 2018. 558 (7711). 620-62
Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein.(2018) García-Nafría J.*, Lee Y.*, Bai X., Carpenter B. & Tate CG. Elife. 2018. May 4;7. pii: e35946.
Structure and organization of heteromeric AMPA-type glutamate receptors. (2016)Herguedas B*, García-Nafria J*, Cais O, Fernandez-Leiro R, Ho H, Krieger J, Greger IH. Science. 2016. Apr 29;352(6285):aad3873
IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly. (2016)García-Nafria J, Watson JF, Greger IH. Scientific Reports.. Jun 6;6:27459.


18 October 2019

Our review about DNA assembly using in vivo bacterial recombination is out! See here.

10 September 2019

Opening day for the lab!!