Signal Transduction Lab
Selected publications
Molecular determinants of β-arrestin coupling to formoterol-bound β1-adrenoceptor. (2020)Lee Y., Warne T., Nehme R., Pandey S., Chaturvedi M., Dwivedi-Agnihotri H., Edwards P., García-Nafría J., Leslie A., Shukla AK., Tate CG.Nature. 2020 Jun 17. doi: 10.1038/s41586-020-2419-1.
Cryo-Electron Microscopy: Moving Beyond X-ray Crystal Structures for Drug receptors and Drug development. (2019) García-Nafría J. and Tate CG. Annual Reviews in Pharmacology and Toxicology. 2020 Jan 6;60:51-71. doi: 10.1146/annurev-pharmtox-010919-023545.
Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8. (2019)Herguedas B, Watson JF, Ho H, Cais O, García-Nafría J, Greger IH.Science. 2019 Mar 14. pii: eaav9011
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.(2018)García-Nafría J., Nehme R., Edwards P., Tate CG.Nature, 2018. 558 (7711). 620-62
Structure and organization of heteromeric AMPA-type glutamate receptors. (2016)Herguedas B*, García-Nafria J*, Cais O, Fernandez-Leiro R, Ho H, Krieger J, Greger IH. Science. 2016. Apr 29;352(6285):aad3873
IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly. (2016)García-Nafria J, Watson JF, Greger IH. Scientific Reports.. 2016 Jun 6;6:27459.
News
April 2024
Beautiful story trying to explain the mechanism of dopamine receptor variants that produce motor and neurological deffects. We made our little contribution to help:
https://www.sciencedirect.com/science/article/abs/pii/S0006295224002119?via%3Dihub
March 2023
Welcome Kleopatra Papadouli to the group! An Erams+ student!
February 2023
Welcome Andrés Gonzalez to the group!
January 2023
Welcome Natalia Garré to the group! :)
October 2022
Welcome Iris del Val García to the group, new PhD student addition! :)
June 2022
Very honoured to receive the "Enrique Pere Payá" prize by the Sociedad Española de Biofísica.
April 2021
Article at the SEBBM, science outreach. Great iniciative by the SEBBM to get science to everyone.
http://dx.doi.org/10.18567/sebbmdiv_ANC.2021.04.1
17 January 2021
Grateful to get a Instruct Pilot Study Award! We are happy to get seed funding to try high risk/high gain ideas!
01 January 2021
Congratulations Sandra for obtaining a DGA PhD fellowship.
21 December 2020
Our review is featured in The atlas of science: https://atlasofscience.org/cryo-electron-microscopy-in-drug-development/
16 October 2020
Congratulations to Iris del Val García for obtaining the undergrad research fellowship "beca de colaboración" to work in the lab. Exciting moments ahead!!
09 October 2020
We are grateful to the BBVA Leonardo Fundation for the Beca Leonardo a Investigadores y Creadores Culturales 2020. We will do our best!
17 June 2020
The arrestin work gets highlighted in the TV news, newspapers and radio.
17th June 2020
Very happy to share the latest work on arrestin-complex with b1AR in a nanodisc, a great effort from Yang Lee!! See here.
25th February 2020
Great collaboration with Silvia Hernández Ainsa on creating DNA origami resembling clathrin molecules to stabilize lipid vesicles. See here.
18th October 2019
Our review about DNA assembly using in vivo bacterial recombination is out! See here.
10th September 2019
Opening day for the lab!!
