Our research focuses on the neuro-cardiovascular interface, exploring how the central nervous system (CNS) — particularly brain and spinal cord — regulates cardiovascular function through molecular, cellular, and physiological mechanisms. Specifically, we investigate the roles of neurotransmitter systems, NMDA receptor signaling, neuropeptides, and oxidative stress in modulating the brain–heart axis and contributing to cardiovascular and neurodegenerative diseases.

Within this scope, we integrate Cardiovascular Pharmacology, Neuropharmacology, and Neurophysiology to understand how CNS neuronal activity and receptor function influence blood pressure (BP), heart rate (HR), and vascular tone. Central to our work is the NMDA receptor, which regulates calcium and sodium ion fluxes crucial for neuronal excitability and synaptic communication. Dysregulation of NMDA receptor activity can disrupts CNS control of cardiovascular function, leading to hypertension, arrhythmia, and cardiac dysfunction.

Our investigations further explore how neuropeptides modulate NMDA receptor signaling and affect central sympathetic regulation within key autonomic centers of the CNS, including the PVN, RVLM, CVLM, and NTS, which are critical for maintaining cardiovascular homeostasis. Aberrant excitatory signaling or oxidative stress within these regions enhances sympathetic outflow, a hallmark feature of neurogenic hypertension.

Additionally, our research extends to ferroptosis, a form of regulated cell death driven by lipid peroxidation and iron overload, which links oxidative stress to both neuronal and cardiovascular degeneration. By examining ferroptotic and oxidative pathways, we aim to identify therapeutic strategies that mitigate cellular injury in disorders such as Alzheimer’s disease and hypertension.

Overall, our research seeks to bridge neuroscience, neurophysiological mechanisms with cardiovascular physiology, providing mechanistic insights into how the CNS orchestrates cardiovascular regulation and identifying molecular targets for treating neuro-cardiovascular diseases.

Currently working in the field of regenerative medicine, with a primary focus on stem cell–based therapies and platelet-rich plasma (PRP)–based regenerative approaches for androgenetic alopecia (AGA), skin rejuvenation, tissue repair, and musculoskeletal and joint-related conditions. My research focuses on the therapeutic potential of adipose-derived stem cells (ADSCs), peripheral blood-derived stem cells (PBSCs), and stem cell–derived secretomes and extracellular vesicles (exosomes), with particular interest in their roles in hair follicle regeneration, skin repair, angiogenesis, tissue regeneration, oxidative stress, and inflammation modulation. Through translational and clinically oriented research, I aim to contribute to the development and advancement of safe, evidence-based regenerative therapies for hair restoration, skin health, tissue repair, and joint-related disorders.