Giese, M. Ramakrishnan, G., Dovan, J., Steenberge, L.H., Sauer, JD, and Huttenlocher, A.. Staphylococcus aureus lipid factors modulate melanoma clustering and invasion in zebrafish. Disease Models and Mechanisms. 2024 Sep 1;17(9):dmm050770.PMCID:PMC11423913
Shen S, Miskolci V, Dewey CN, Sauer, JD*, Huttenlocher A*. Infection induced inflammation impairs wound healing through IL-1β signaling. iScience. 2024 Mar 19;27(4):109532. PMCID: PMC10993181
Sauer, JD, Mandel MJ. Special Collection on the 28th Annual Midwest Microbial Pathogenesis Conference. Infect Immun. 2024 Apr 9;92(4) PMCID: PMC11003223
Smith, H.B., Lee, K., Freeman, M.J., Stevenson, D.M., Amador-Noguez, D., Sauer, JD. Listeria monocytogenes requires DHNA-dependent intracellular redox homeostasis facilitated by Ndh2 for survival and virulence. Infection and Immunity 2023 Oct 17;91(10) PMCID: PMC10580952
West, K.H.J, Ma, S.V, Pensinger, D.A., Tucholski, T., Tiambeng, T.T., Eisenbraun, E.L., Yehuda, A., Hayouka, Z., Ge, Y., Sauer, JD, Blackwell, H.E. A native autoinducing peptide reveals highly efficacious synthetic inhibitors and activators of Listeria monocytogenes quorum sensing and biofilm formation. Biochemistry 2023 Oct 3;62(19):2878-2892 PMCID: PMC10676741
Leasure, C.S.*, Grunenwald, C.M.*, Choby, J.E., , Sauer, JD*, Skaar E.P.* Maintenance of heme homeostasis in 1 Staphylococcus aureus through posttranslational regulation of glutamyl-tRNA reductase Journal of Bacteriology 2023 Sep 26;205(9) PMCID: PMC10521356
Morrow, Z.T. and Sauer, JD. Type I Interferon Signaling on Antigen-Presenting Cells Blunts Cell-Mediated Immunity Toward Listeria monocytogenes. Infection and Immunity 2023 Jul 18;91(7). PMCID: PMC10353425
Robertson, T.F., Yiran Hou, Y., Shen, S., Rindy, J., Sauer, JD., Dinh, H.Q., and Huttenlocher, A.A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish PNAS 2023 May 16;120(20) PMCID: PMC10193988
Pensinger, D.A.*, Gutierrez, K.V.*, Smith, H.B., Vincent, W.J.B., Stevenson, D.S., Black, K.A., Perez-Medina, K.M., Dillard, J.P., Rhee, K.Y., Amador-Noguez, D., Hyunh, T.N., Sauer, JD Listeria monocytogenes GlmR is an accessory uridyltransferase essential for cytosolic survival and virulence. mBio 2023 Mar 20;e0007323. doi: 10.1128/mbio.00073-23. 1. PMCID: PMC10193988
Ye, M., Zhao, Y., Wang, Y., Xie, R., Tong, Y., Sauer, JD. Gong,S. NAD(H) loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis. Nature Nanotechnology. 2022 Aug;17(8):880-890 PMCID:pending
Rivera-Lugo, R., Deng, D., Anaya-Sanchez, A., Tejedor-Sanz, S., Tang, E., Reyes Ruiz, V.M., Smith, H.B., Titov, D.V., Sauer, JD, Skaar, E.P., Ajo-Franklin, C.M., Portnoy, D.A., Light, S.H. Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis. Elife, 2022 Apr 5;11e75424 PMCID:pending
Miskolci, V., Tweed, K., Lasarev, M., Berge, E., Britt, E., McDougal, C.E., Walsh, A., Trier, S., Fan, J., Sauer, JD, Skala, M.C., Huttenlocher, A., In vivo fluorescence lifetime imaging captures metabolic changes in macrophages during wound responses in zebrafish. Elife 2022 Feb 24;11:e66080. PMCID: PMC8871371
Wentz, T.G., Tremblay, B.J.M., Bradshaw, M., Doxey, A.C., Sharma, S.K., Sauer, JD and Pellett, S. CRISPR-Cas systems in Group I C. botulinum and C. sporogenes do not directly target the botulinum neurotoxin gene cluster. Frontiers Microbiology. 2022 Feb 9;12:787726. PMCID: PMC8865420
Kelliher, J.L., Grunenwald, C., Abrahams, R.R., Daanen, M.E., Lew, C.I., Rose, W.E., Sauer, JD. PASTA kinase-dependent control of peptidoglycan synthesis via ReoM is required for cell wall stress responses, cytosolic survival, and virulence in Listeria monocytogenes PLoS Pathogens 2021 Oct 8;17(10):e1009881.
McDougal, C.E., Morrow, Z.T., Kim, S., Carter, D., Stevenson, D.M., Amador-Noguez, D., Miller, M.J., Sauer, JD Prostaglandin E2 induction by cytosolic Listeria monocytogenes in phagocytes is necessary for optimal T-cell priming. PLoS Pathogens 2021 Sep 23;17(9):e1009493. doi: 10.1371/journal.ppat.1009493
Hess, N.J., Bharadwaj, N.S., Bobeck, E.A., Mcdougal, C.E., Ma, S., Sauer, JD, Hudson, A.W., Gumperz, J.E. Invariant natural killer T cell immunotherapy stabilizes human umbilical cord blood engraftment by silencing T cell inflammation. 2021 Jun 10;4(7):e202000999.
Smith, H.B., Li, T.L., Liao, M.K., Chen, G.Y., Guo, Z., Sauer, JD. Listeria monocytogenes MenI encodes a DHNA-CoA thioesterase necessary for menaquinone biosynthesis, cytosolic survival, and virulence. Infection and Immunity. 2021 Apr 16;89(5):e00792-20.
Lee, W., Kingstad-Bakke, B., Paulson, B., Larsen, A.R., Overmyer, K., Marinaik, C.B., Dulli, K., Toy, R., Vogel, G., Mueller, K.P., Tweed, K., Walsh, A.J., Russell, J., Saha, K., Reyes, L., Skala, M.C., Sauer, JD, Shayakhmetov, D.M., Coon, J., Roy, K., Suresh, M. Carbomer-Based Adjuvant Induces CD8 T Cell Immunity by Inducing a Distinct Metabolic State in Cross-Presenting Dendritic Cells. PLoS Pathogens. 2021 Jan 14;17(1):e1009168.
Schurig-Briccio, L.A., Parraga Solorzano, P.K., Lencina, A.M., Radin, J.N., Chen, G.Y., Sauer, JD., Kehl-Fie, T.E., Gennis, R.B. Role of respiratory NADH oxidation in the regulation of Staphylococcus aureus virulence. EMBO Reports 2020 May 6;21(5):e45832.
Morrow, Z.T., Powers, Z.M., Sauer, JD. Listeria monocytogenes Cancer Vaccines: Bridging Innate and Adaptive Immunity Current Clinical Microbiology Reports First Online: 20 Nov. 2019
Chen, G.Y*., Kao, CY*, Smith, H.B, Rust, D.P., Powers, Z.M. Li, A.Y., Sauer, JD. Mutation of the transcriptional regulator YtoI rescues Listeria monocytogenes mutants deficient in the essential shared metabolite 1,4-dihydroxy-2-naphthoate (DHNA). Infection and Immunity 2019 Dec 17;88(1):e00366-19
Sauer JD, Herskovits AA, O'Riordan MXD. Metabolism of the Gram-Positive Bacterial Pathogen Listeria monocytogenes. Microbiol Spectr. 2019 Jul;7(4).
Ristow, L.C., Tran, V., Schwatz, K.J., Pankratz, L., Mehle, A., Sauer, JD, Welch, R.A. The extracellular domain of the beta-2 integrin beta subunit (CD18) is sufficeint for Escherichia coli hemolysin and Aggregatibacter actinomycetemcomitans leukotoxin cytotoxic activity. mBio 2019 July 9. pii: e01459-19
Miskolci, V.*, Squirrell, J.M.*, Rindy, J., Vincent, W.J.B., Sauer, JD, Gibson, A, Eliceiri, K.W., and Huttenlocher, A. Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish. eLife 2019 Jul 1;8. pii: e45976. doi: 10.7554/eLife.45976.
Wlodarchak, N., Teachout, N., Beczkiewicz, J., Procknow, R., Schaenzer, A.J., Satyshur, K., Pavelka, M., Zuercher, B., Drewry, D., Sauer, JD., Striker, R. An in silico screen and structural analysis identifies bacterial kinase inhibitors which act with β-lactams to inhibit mycobacterial growth. Mol Pharm. 2018 Nov 5;15(11):5410-5426. PMCID: PMC6648700
Sauer JD. An immune response with a sweet tooth. Nature. 2018 Sep;561(7721):37-38. doi: 10.1038/d41586-018-05854-y.
Schaenzer, A.J., Wlodarchak, N, Drewry, D.J, Zuercher, D.J, Rose, W.E., Ferrer, C.A., Sauer, JD, Striker, R. GW779439X and its pyrazolopyridazine derivatives inhibit the serine/threonine kinase Stk1 and act as antibiotic adjuvants against β-lactam-resistant Staphylococcus aureus. ACS Infectious Disease. 2018 Oct 12;4(10):1508-1518. PMCID:PMC6779124
Johnson, L.E., Brockstedt, D., Leong, M., Lauer, P., Theisen, E.M., Sauer, JD, McNeel, D.G. Heterologous vaccination targeting prostatic acid phosphatase (PAP) using DNA and Listeria vaccines elicits superior anti-tumor immunity dependent on CD4+ T cells elicited by DNA priming. OncoImmunology. 2018 doi: 10.1080/2162402X.2018.1456603 PMCID:PMC6136874
Theisen, E.M*., McDougal, C.E.*, Nakanishi, M., Amador-Noguez, D., Rosenberg, D.W., Knoll, L.J., Sauer, JD. Cyclooxygenase-1 and -2 Play Contrasting Roles in Listeria Stimulated Immunity. Journal of Immunology. 2018 Jun 1;200(11):3729-3738 PMCID: PMC5964023
McDougal, C.E. and Sauer, JD. Listeria monocytogenes: The Impact of Cell Death on Infection and Immunity. Pathogens. 2018 7(1), 8; doi: 10.3390/pathogens7010008. PMCID: PMC5874734
Pensinger, D.A., Schaenzer, A.J., Sauer, JD. Do Shoot the Messenger: PASTA Kinases as Virulence Determinants and Antibiotic Targets. Trends Microbiol. 2018 Jan;26(1):56-69 PMCID: PMC5741517
Reyes, V.M., Ramireza, J., Naseera, N., Palacioa, N.M., Siddarthana, I.J., Yana, B., Boyera, M.A., Pensinger, D.A., Sauer, JD, Shin, S. Broad Detection of Bacterial Type III Secretion System and Flagellin Proteins by the Human NAIP/NLRC4 Inflammasome. Proc. Natl. Acad. Sci. USA. 2017 Dec. 12;114(50):13242-13247. PMCID: PMC5740664
Schaenzer, A.J., Wlodarchak, N., Drewry, D.H., Zuercher W.J., Rose, W.E., Striker, R., Sauer, JD. A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA. J Biol Chem. 2017 Oct 13;292(41):17037-17045. PMCID:PMC5641865
Vincent, W.J.B., Harvie, E.A., Sauer, JD, Huttenlocher, A. Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection. PLoS One. 2017 Jun 28;12(6):e0179574. PMCID:PMC5489177.
Chen, G.Y., Pensinger, D.A., Sauer, JD. Listeria monocytogenes cytosolic metabolism promotes replication, survival, and evasion of innate immunity. Cell Microbiol. 2017 Oct;19(10) PMCID:PMC5587384
Chen, G.Y., McDougal, C.E., D’Antonio, M.A., Portman, J.L. and Sauer, JD. A Genetic Screen Reveals that Synthesis of 1,4-Dihydroxy-2-Naphthoate (DHNA), but Not Full-Length Menaquinone, Is Required for Listeria monocytogenes Cytosolic Survival. MBio. 2017 Mar 21;8(2). pii: e00119-17. PMCID:PMC5362031
Theisen, E.M. and Sauer, JD. Listeria monocytogenes Induced Cell Death Inhibits the Generation of 1 Cell-Mediated Immunity. Infection and Immunity. 2016 Nov 7. pii: IAI.00733-16. PMCID:PMC5203660
Pensinger, D.A., Boldon, K.M., Chen, G.Y., Vincent, W.J.B, Sherman, K., Xiong, M., Schaenzer, A.J., Forster, E.R., Coers, J., Striker, R., Sauer, JD. The Listeria monocytogenes PASTA kinase PrkA and its substrate YvcK are required for cell wall homeostasis, metabolism, and virulence. PLoS Pathogens 2016 Nov 2;12(11):e1006001 PMCID:PMC5091766
Felley LE, Sharma A, Theisen E, Romero-Masters JC, Sauer JD, Gumperz JE. Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway. Journal of Immunology. 2016 Sep 15;197(6):2455-64PMCID:PMC5011004
Theisen, E and Sauer, JD. Listeria monocytogenes and the inflammasome: from cytosolic bacteriolysis to tumor immunotherapy. Current Topics in Microbiology and Immunology. 2016;397:133-60 PMCID:PMC5027901
Vincent, W.J.B., Freisinger, C.M., Lam, P., Huttenlocher, A., Sauer, JD. Macrophages Mediate Flagellin Induced Inflammasome Activation and Host Defense in Zebrafish. Cellular Microbiology 2016;18(4):591-604 PMCID:PMC5027955
Berti, A.D., Theisen, E, Sauer, JD, Nonejuie, P., Olson, J., Pogliano, J., Sakoulas, G., Nizet, V., Proctor, R.A., Rose, W.E. Penicillin binding protein 1 is important in the compensatory response of Staphylococcus aureus to daptomycin-induced membrane damage and is a potential target for β-lactam-daptomycin synergy. Antimicrobial Agents and Chemotherapy. 2015;60(1):451-8. PMCID:PMC4704217
Huynh, T.N., Luo, S., Pensinger, D.A., Sauer, JD, Tong, L., Woodward, J.J. An HD-domain Phosphodiesterase Mediates Cooperative Hydrolysis of c-di-AMP to Affect Bacterial Growth and Virulence. Proc. Natl. Acad. Sci. 2015; 112(7):E747-56 PMCID:PMC4343097
Kamakshi S., Choi, P., Precit, M., Delince, M., Pensinger, D.A., Ngoc Huynh, T., Jurado, A.R., Ah Goo, Y., Sadilek, M., Iavarone, A.T., Sauer, JD, Tong, T., Woodward, J.J. The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator Of Metabolic Enzyme Function. Cell. 2014; 158(6):1389-401 PMCID:PMC4166403
Pensinger, D.A., Aliota, M.T., Schaenzer, A.J., Bolden, K.M., Ansari, I.H., Vincent, W.J.B., Knight, B, Reniere, M.L., Striker, R., Sauer, JD. Selective Pharmacologic Inhibition of a PASTA Kinase Increases Listeria monocytogenes Susceptibility to β-lactam Antibiotics. Antimicrobial Agents and Chemotherapy. 2014; 58(8):4486-94 PMCID:PMC4135996
Fonseca, M.V., Sauer, JD. Crepin, S., Byrne, B and Swanson, M.S. The phtC-phtD locus equips Legionella pneumophila for thymidine salvage and replication in macrophages. Infection and Immunity. 2014; 82(2). PMCID:PMC3911408
Williams, C.R., Dustin, M.L. and Sauer, JD. Inflammasome-mediated inhibition of Listeria monocytogenes-stimulated immunity is independent of myelomonocytic function. PLOS One. 2013; 8(12). PMCID: PMC3857309
Witte, C.E., Whiteley, A.T., Burke, T.P., Sauer, JD, Portnoy, D.A., Woodward, J.J. Cyclic di-AMP is Critical for Listeria monocytogenesGrowth, Cell Wall Homeostasis, and Establishment of Infection. MBio. 2013;4(3). PMCID: PMC3663569
Witte, C.E., Archer, K.A., Rae, C.S., Sauer, JD, Woodward, J.J. and Portnoy, D.A. Innate Immune Pathways Triggered by Listeria monocytogenes and Their Role in the Induction of Cell-Mediated Immunity. Advances in Immunology. 2012; 113:135-56. PMID22244582
Sauer, JD., Peryere, S., Archer, K.A., Hanson, B., Lauer, P., Portnoy, D.A. Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and fail to induce protective immunity. Proc. Natl. Acad. Sci. USA. 2011; 108(30): 12419-12424. PMCID: PMC3145703
Lightfield, K.L., Persson, J., Trinidad, N.J., Brubaker, S.W., Kofoed, E.M., Sauer, JD, Dunipace, E.A., Warren, S.E., Miao, E.A., Vance, R.E. Differential requirements for Naip5 in activation of the Nlrc4 (Ipaf) inflammasome. Infection and Immunity. 2011; 79(4):1606-14. PMCID: PMC3067563
Sauer, JD., Sotelo-Troha, K., Brubaker, S.W., von Moltke, J., Monroe, K.M., Rae, C., Hyodo, M., Hayakawa, Y., Woodward, J.J., Portnoy, D.A., Vance, R.E. The ENU-induced Goldenticket (Gt) mouse mutant reveals an essential function of Sting(Tmem173, Mita, Mpys, Eris) in the in vivo interferon response to Listeria monocytogenes and cyclic-di-nucleotides. Infection and Immunity. 2011; 79(2):688-94. PMCID: PMC3028833
Sauer, JD., Witte, C.E., Zemansky, J., Hanson, B., Lauer, P., Portnoy, D.A. Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol. Cell Host & Microbe. 2010; 7(5):412-419. PMCID: PMC2947455
Henry, T., Kirimanjeswara, G.S., Jones, J.W., Sauer, JD, Iwakura, Y., Metzger, D.W., Monack, D.M. Type I Interferon signaling constrains IL-17A/F secretion by gd T-cells during bacterial infections. Journal of Immunology. 2010; 184(7):3755-3767. PMCID: PMC2879123
Chen, D.E., Podell, S., Sauer, JD, Swanson, M.S., and Saier, M.H. Jr. The Phagosomal nutrient transporter (Pht) family. Microbiology2008; 154: 42-53. PMID18174124
Sauer, JD, Shannon, J.G., Howe, D., Hayes, S.F., Swanson, M.S. and Heinzen, R.A. Specificity of Legionella pneumophila and Coxiella burnetii vacuoles and versatility of Legionella pneumophila revealed by coinfection. Infection and Immunity. 2005; 73(8):4494-504. PMCID: PMC1201193
Sauer, JD, Bachman, M.A., Swanson, M.S. The PhtA transporter couples threonine acquisition to differentiation and replication of Legionella pneumophila. Proc. Natl. Acad. Sci. USA. 2005; 102: 9924-9929. PMCID: PMC1174991