Sauer Lab

University of Wisconsin-Madison

Research Focus

The focus of our lab revolves around understanding host pathogen interactions. Specifically we are interested in three separate but related questions:

1. How do intracellular pathogens parasitize their host cells?

2. How does the host recognize infection by intracellular pathogens?

3. How does recognition of intracellular pathogens by the innate immune system drive adaptive immune responses?

Recent Publications

Reyes, V.M., Ramireza, J., Naseera, N., Palacioa, N.M., Siddarthana, I.J., Yana, B., Boyera, M.A., Pensinger, D.A., Sauer, JD, Shin, S. Broad Detection of Bacterial Type III Secretion System and Flagellin Proteins by the Human NAIP/NLRC4 Inflammasome. Proc. Natl. Acad. Sci. USA. 2017 Nov 27. pii: 201710433. doi: 10.1073/pnas.1710433114. [Epub ahead of print]

Schaenzer, A.J., Wlodarchak, N., Drewry, D.H., Zuercher W.J., Rose, W.E., Striker, R., Sauer, JD. A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA. J Biol Chem. 2017 Aug 16. pii: jbc.M117.808600. doi: 10.1074/jbc.M117.808600. [Epub ahead of print]

Pensinger, D.A., Schaenzer, A.J., Sauer, JD. Do Shoot the Messenger: PASTA Kinases as Virulence Determinants and Antibiotic Targets. Trends Microbiol. 2017 Jul 19. pii: S0966-842X(17)30155-5. doi: 10.1016/j.tim.2017.06.010. [Epub ahead of print] PMCID:In Progress

Vincent, W.J.B., Harvie, E.A., Sauer, JD, Huttenlocher, A. Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection. PLoS One. 2017 Jun 28;12(6):e0179574. PMCID:PMC5489177.

Chen, G.Y., Pensinger, D.A., Sauer, JD. Listeria monocytogenes cytosolic metabolism promotes replication, survival, and evasion of innate immunity. Cell Microbiol. 2017 Jun 27. doi: 10.1111/cmi.12762. [Epub ahead of print] PMCID: In Progress

Chen, G.Y., D’Antonio, M.A., McDougal, C.E. and Sauer, JD. A Genetic Screen Reveals that Synthesis of 1,4-Dihydroxy-2-Naphthoate (DHNA), but Not Full-Length Menaquinone, Is Required for Listeria monocytogenes Cytosolic Survival. MBio. 2017 Mar 21;8(2). pii: e00119-17.

Recent News

Hans Smith has joined the lab!

Dan Pensinger's paper with the Shin lab was published in PNAS!

Cheng-Yen Kao has joined the lab!

Adam Schaenzer's paper was accepted into The Journal of Biological Chemistry!

Cadin Truesdale has joined the lab!

Dan Pensinger's review was accepted to Trends in Microbiology!

Coutney McDougal passed her preliminary exams!

Grischa Chen's review was accepted to Cellular Microbiology!

Will Vincent's paper was accepted into PLoS One!

Grischa Chen successfully defended his PhD dissertation! Congratulations to the newly minted Dr. Chen!

Will Vincent successfully defended his PhD dissertation! Congratulations to the newly minted Dr. Vincent!

Emily Forster and Jon Kaletka have graduated!

Grischa Chen has accepted a Postdoctoral Fellow position with Janelle Ayres at the Salk Institute!

Erin Theisen successfully defended her PhD dissertation! Congratulations to the newly minted Dr. Theisen!

Drew Rust was awarded a Hilldale Fellowship!

Will Vincent has accepted a position on the faculty at St. Johnsbury Academy following graduation!

Jon Kaletka has accepted an offer to enroll at Michigan State University for his microbiology PhD!

Emily Forster has accepted an offer to enroll at Tufts University for her microbiology PhD and was awarded a Provosts Fellowship!

Grischa Chen's paper was accepted into mBio!