Sauer Lab

University of Wisconsin-Madison

Research Focus

The focus of our lab revolves around understanding host pathogen interactions. Specifically we are interested in four separate but related questions:

1. How do intracellular pathogens parasitize their host cells?

2. How can we take advantage of pathogen virulence strategies to develop novel antimicrobials?

3. How does the host recognize and respond to infection by intracellular pathogens?

4. How does recognition of intracellular pathogens by the innate immune system drive adaptive immune responses?

Recent Publications

Schurig-Briccio, L.A., Parraga Solorzano, P.K., Lencina, A.M., Radin, J.N., Chen, G.Y., Sauer, JD., Kehl-Fie, T.E., Gennis, R.B. Role of respiratory NADH oxidation in the regulation of Staphylococcus aureus virulence. EMBO Reports 2020 Mar 23:e45832. doi: 10.15252/embr.201845832. [Epub ahead of print]

Zachary T. Morrow, Zachary M. Powers, John-Demian Sauer. Listeria monocytogenes Cancer Vaccines: Bridging Innate and Adaptive Immunity Current Clinical Microbiology Reports First Online: 20 Nov. 2019

Chen, G.Y*., Kao, CY*, Smith, H.B, Rust, D.P., Powers, Z.M. Li, A.Y., Sauer, JD. Mutation of the transcriptional regulator YtoI rescues Listeria monocytogenes mutants deficient in the essential shared metabolite 1,4-dihydroxy-2-naphthoate (DHNA). Infection and Immunity 2019 Nov 4. pii: IAI.00366-19. [Epub ahead of print]

Sauer JD, Herskovits AA, O'Riordan MXD. Metabolism of the Gram-Positive Bacterial Pathogen Listeria monocytogenes. Microbiol Spectr. 2019 Jul;7(4).

Ristow, L.C., Tran, V., Schwatz, K.J., Pankratz, L., Mehle, A., Sauer, JD, Welch, R.A. The extracellular domain of the beta-2 integrin beta subunit (CD18) is sufficeint for Escherichia coli hemolysin and Aggregatibacter actinomycetemcomitans leukotoxin cytotoxic activity. mBio 2019 July 9. pii: e01459-19

Miskolci, V.*, Squirrell, J.M.*, Rindy, J., Vincent, W.J.B., Sauer, JD, Gibson, A, Eliceiri, K.W., and Huttenlocher, A. Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish. eLife Jul 1;8. pii: e45976.

Recent News

Congratulations to Kim Gutierrez whose L. monocytogenes CRISPRi proposal was funded by NIH-NIAID!

Congratulations to McKenzie Daanen on being awarded a prestigious Hilldale Undergraduate Research Fellowship!

Congratulations to Dr. Grischa Chen on the publication of his collaborative paper with Gennis Lab Scientist Dr. Lici Schurig-Briccio, as well as collaborators in the Kehl-Fie Lab!

Congratulations to former Sauer Lab member and current Shen Lab PhD student Emily Forster on her fundable NIH F31 score!

Congratulations to Dr. Jess Kelliher on her fundable NIH F32 score!

Congratulations to former Sauer Lab undergraduate Marc D'Antonio on choosing the University of Colorado Immunology Program to pursue his PhD!

Congratulations to Zach Powers on choosing the University of Michigan PIBS program to pursue his PhD!

Congratulations to Zach Morrow on passing his qualifying exam!

Welcome to the lab, Dr. Caroline Grunenwald!

Congratulations to Zach Powers on his graduation, welcome to your new position as a research specialist in the Sauer Lab!

Welcome to the lab Kim Gutierrez and Simone Shen!

Congratulations to Dr. Grischa Chen, Dr. CY Kao and other collaborating members of the lab on publication of their recent Infection and Immunity paper!

Congratulations to the newly minted Dr. Daniel Pensinger, the newest Sauer Lab graduate!

Congratulations to Hans Smith on passing his qualifying exam!

Congratulations to Dr. Laurie Ristow and our collaborators in the Welch and Mehle labs on publication of their most recent paper, we're proud to be a part of it!

Congratulations to Dr. Veronika Miskolci and our other collaborators in the Huttenlocher Lab on publication of their most recent paper, we're proud to be a part of it!

Welcome to the lab new research specialist, Tighe Christopher!