University of Wisconsin-Madison
The focus of our lab revolves around understanding host pathogen interactions. Specifically we are interested in four separate but related questions:
1. How do intracellular pathogens parasitize their host cells?
2. How can we take advantage of pathogen virulence strategies to develop novel antimicrobials?
3. How does the host recognize and respond to infection by intracellular pathogens?
4. How does recognition of intracellular pathogens by the innate immune system drive adaptive immune responses?
Wlodarchak, N., Teachout, N., Beczkiewicz, J., Procknow, R., Schaenzer, A.J., Satyshur, K., Pavelka, M., Zuercher, B., Drewry, D., Sauer, JD., Striker, R. An in silico screen and structural analysis identifies bacterial kinase inhibitors which act with β-lactams to inhibit mycobacterial growth. Mol Pharm. 2018 Oct 4. doi: 10.1021/acs.molpharmaceut.8b00905. [Epub ahead of print]
Schaenzer, A.J., Wlodarchak, N, Drewry, D.J, Zuercher, D.J, Rose, W.E., Ferrer, C.A., Sauer, JD, Striker, R. GW779439X and its pyrazolopyridazine derivatives inhibit the serine/threonine kinase Stk1 and act as antibiotic adjuvants against β-lactam-resistant Staphylococcus aureus. ACS Infectious Disease. 2018 doi: 10.1021/acsinfecdis.8b00136. [Epub ahead of print]
Johnson, L.E., Brockstedt, D., Leong, M., Lauer, P., Theisen, E.M., Sauer, JD, McNeel, D.G. Heterologous vaccination targeting prostatic acid phosphatase (PAP) using DNA and Listeria vaccines elicits superior anti-tumor immunity dependent on CD4+ T cells elicited by DNA priming. OncoImmunology. 2018 doi: 10.1080/2162402X.2018.1456603 [Epub ahead of print]
Theisen, E.M., McDougal, C.E., Nakanishi, M., Amador-Noguez, D., Rosenberg, D.W., Knoll, L.J., Sauer, JD. Cyclooxygenase-1 and -2 Play Contrasting Roles in Listeria Stimulated Immunity. Journal of Immunology. 2018 Apr 20. pii: ji1700701. doi: 10.4049/jimmunol.1700701. [Epub ahead of print]
Congratulations to new lab member Zach Morrow on receiving the NSF GRFP!
Welcome to the lab new CMB student, Zach Morrow!
Congratulations to Dan Pensinger on winning a poster award at the Perlman Symposium!
Congratulations to Zach Powers on being awarded the Department of Bacteriology Undergraduate Research Fellowship!
Congratulations to Sauer Lab postdoc Dr. CY Kao on getting his dream job as an assistant professor in the Institute of Microbiology & Immunology at National Yang-Ming University!
The Sauer Lab was awarded a new R21 to study the MRSA antibiotic target Stk1!
Congratulations to Sauer Lab postdoc Dr. CY Kao on his recognition as the ASM Young Ambassador to Taiwan!
We are excited to welcome Dr. Jess Kelliher to the lab as a new postdoc!
Congratulations to our longtime undergraduate Matt Becraft on his graduation!
We are excited to welcome Drew Rust as our new lab manager!