University of Wisconsin-Madison
The focus of our lab revolves around understanding host pathogen interactions. Specifically we are interested in three separate but related questions:
1. How do intracellular pathogens parasitize their host cells?
2. How does the host recognize infection by intracellular pathogens?
3. How does recognition of intracellular pathogens by the innate immune system drive adaptive immune responses?
Chen, G.Y., D’Antonio, M.A., McDougal, C.E. and Sauer, JD. A Genetic Screen Reveals that Synthesis of 1,4-Dihydroxy-2-Naphthoate (DHNA), but Not Full-Length Menaquinone, Is Required for Listeria monocytogenes Cytosolic Survival. MBio. 2017 Mar 21;8(2). pii: e00119-17.
The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence. Pensinger DA, Boldon KM, Chen GY, Vincent WJ, Sherman K, Xiong M, Schaenzer AJ, Forster ER, Coers J, Striker R, Sauer JD. PLoS Pathog. 2016 Nov 2;12(11):e1006001. doi: 10.1371/journal.ppat.1006001.
Felley LE, Sharma A, Theisen E, Romero-Masters JC, Sauer JD, Gumperz JE. Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway. Journal of Immunology. 2016Sep 15;197(6):2455-64.
Will Vincent's paper was accepted into PLoS One!
Grischa Chen successfully defended his PhD dissertation! Congratulations to the newly minted Dr. Chen!
Will Vincent successfully defended his PhD dissertation! Congratulations to the newly minted Dr. Vincent!
Emily Forster and Jon Kaletka have graduated!
Grischa Chen has accepted a Postdoctoral Fellow position with Janelle Ayres at the Salk Institute!
Erin Theisen successfully defended her PhD dissertation! Congratulations to the newly minted Dr. Theisen!
Drew Rust was awarded a Hilldale Fellowship!
Will Vincent has accepted a position on the faculty at St. Johnsbury's Academy following graduation!
Jon Kaletka has accepted an offer to enroll at Michigan State University for his microbiology PhD!
Emily Forster has accepted an offer to enroll at Tufts University for her microbiology PhD and was awarded a Provosts Fellowship!
Grischa Chen's paper was accepted into mBio!
Adam Schaenzer was awarded a PhRMA predoctoral fellowship!
Courtney McDougal was awarded an AAI Young Investigator Award at the Autumn Immunology Conference!