Sauer Lab

University of Wisconsin-Madison

Research Focus

The focus of our lab revolves around understanding host pathogen interactions. Specifically we are interested in three separate but related questions:

1. How do intracellular pathogens parasitize their host cells?

2. How does the host recognize infection by intracellular pathogens?

3. How does recognition of intracellular pathogens by the innate immune system drive adaptive immune responses?

Recent Publications

Johnson, L.E., Brockstedt, D., Leong, M., Lauer, P., Theisen, E.M., Sauer, JD, McNeel, D.G. Heterologous vaccination targeting prostatic acid phosphatase (PAP) using DNA and Listeria vaccines elicits superior anti-tumor immunity dependent on CD4+ T cells elicited by DNA priming. OncoImmunology. 2018 doi: 10.1080/2162402X.2018.1456603 [Epub ahead of print]

Theisen, E.M., McDougal, C.E., Nakanishi, M., Amador-Noguez, D., Rosenberg, D.W., Knoll, L.J., Sauer, JD. Cyclooxygenase-1 and -2 Play Contrasting Roles in Listeria Stimulated Immunity. Journal of Immunology. 2018 Apr 20. pii: ji1700701. doi: 10.4049/jimmunol.1700701. [Epub ahead of print]

McDougal, C., Sauer, JD. Listeria monocytogenes: The impact of Cell Death on Infection and Immunity. Pathogens. 2018 Jan 11. doi: 10.3390/pathogens7010008

Reyes, V.M., Ramireza, J., Naseera, N., Palacioa, N.M., Siddarthana, I.J., Yana, B., Boyera, M.A., Pensinger, D.A., Sauer, JD, Shin, S. Broad Detection of Bacterial Type III Secretion System and Flagellin Proteins by the Human NAIP/NLRC4 Inflammasome. Proc. Natl. Acad. Sci. USA. 2017 Nov 27. pii: 201710433. doi: 10.1073/pnas.1710433114. [Epub ahead of print]

Schaenzer, A.J., Wlodarchak, N., Drewry, D.H., Zuercher W.J., Rose, W.E., Striker, R., Sauer, JD. A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA. J Biol Chem. 2017 Aug 16. pii: jbc.M117.808600. doi: 10.1074/jbc.M117.808600. [Epub ahead of print]

Pensinger, D.A., Schaenzer, A.J., Sauer, JD. Do Shoot the Messenger: PASTA Kinases as Virulence Determinants and Antibiotic Targets. Trends Microbiol. 2017 Jul 19. pii: S0966-842X(17)30155-5. doi: 10.1016/j.tim.2017.06.010. [Epub ahead of print] PMCID:In Progress

Vincent, W.J.B., Harvie, E.A., Sauer, JD, Huttenlocher, A. Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection. PLoS One. 2017 Jun 28;12(6):e0179574. PMCID:PMC5489177.

Chen, G.Y., Pensinger, D.A., Sauer, JD. Listeria monocytogenes cytosolic metabolism promotes replication, survival, and evasion of innate immunity. Cell Microbiol. 2017 Jun 27. doi: 10.1111/cmi.12762. [Epub ahead of print] PMCID: In Progress

Recent News

Courtney McDougal was selected as a recipient of the Microbes in Health and Disease fellowship!

The Sauer Lab was awarded a Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease Award!

Erin Theisen and Courtney McDougal's paper was accepted for publication at the Journal of Immunology in collaboration with the Knoll Lab, the Amador-Noguez Lab, and the Rosenberg Lab!

Erin Theisen's paper with the McNeel Lab was accepted for publication at OncoImmunology !

Adam Schaenzer has accepted an offer of a postdoc with Dr. Gerry Wright starting fall of 2018!

Zach Powers has joined the lab!

Courtney McDougal's review on cell death and immunity was accepted for publication at Pathogens!

Hans Smith has joined the lab!

Dan Pensinger's paper with the Shin lab was published in PNAS!

Cheng-Yen Kao has joined the lab!

Adam Schaenzer's paper was accepted into The Journal of Biological Chemistry!

Dan Pensinger's review was accepted to Trends in Microbiology!

Coutney McDougal passed her preliminary exams!

Grischa Chen's review was accepted to Cellular Microbiology!