Papers

Submitted

• Robust tissue pattern formation by coupling morphogen signal and cell adhesion.

Kosuke Mizuno, Tsuyoshi Hirashima*, Satoshi Toda*

2024

• Programming spatial cell sorting by engineering cadherin intracellular activity.

Hikari Baba, Tomohiro Fujita, Kosuke Mizuno, Mai Tambo, Satoshi Toda*

ACS Synthetic Biology. 13, 1705-1715 (2024)

• Designer cell therapy for tissue regeneration.

Noyuri Zama, Satoshi Toda*

Inflammation and Regeneration. 44, Article number: 15 (2024) (Review)

2023

• Instructional materials that control cellular activity through synthetic Notch receptors.

Joanne C. Lee, Hannah J. Brien, Bonnie L. Walton, Zachary M. Eidman, Satoshi Toda, Wendell A. Lim*, Jonathan M. Brunger*

Biomaterials. 297, 122099 (2023) 

2022

• Intestinal and optic-cup organoids as tools for unveiling mechanics of self-organizing morphogenesis.

Sristilekha Nath, Satoshi Toda, Satoru Okuda*

Biophysics and Physicobiology. 19, e190048 (2022) (Review)

• Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases.

Satoshi Watanabe*, Yuta Nihongaki, Kie Itoh, Toru Uyama, Satoshi Toda, Shigeki Watanabe, Takanari Inoue*

Nature Communications. 13, 4413 (2022)

• Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells.

Keisuke Kuromiya, Kana Aoki, Kojiro Ishibashi, Moe Yotabun, Miho Sekai, Nobuyuki Tanimura, Sayuri Iijima, Susumu Ishikawa, Tomoko Kamasaki, Yuki Akieda, Tohru Ishitani, Takashi Hayashi, Satoshi Toda, Koji Yokoyama, Chol Gyu Lee, Ippei Usami, Haruki Inoue, Ichigaku Takigawa, Estelle Gauquelin, Kaoru Sugimura, Naoya Hino, Yasuyuki Fujita*

Cell Reports. 40, 111078 (2022)

2020

• Engineering synthetic morphogen systems that can program multicellular patterning. 

Satoshi Toda*, Wesley L. McKeithan, Teemu J. Hakkinen, Pilar Lopez, Ophir D. Klein, Wendell A. Lim*. 

Science. 370, 327-331 (2020), Press release, Research Highlights (in Japanese)

Featured in Naama Barkai, Ben-Zion Shilo. "Reconstituting tissue patterning." Science 370, 292-293 (2020).

• Synthetic tissue engineering: Programming multicellular self-organization by designing customized cell-cell communication.

Satoshi Toda*. 

Biophysics and Physicobiology. 17, 42-50 (2020) (Review)

2019

• Engineering cell–cell communication networks: programming multicellular behaviors.

Satoshi Toda, Nicholas W Frankel, Wendell A Lim*. 

Current Opinion in Chemical Biology. 52, 31-38 (2019) (Review)

• Synthetic development: learning to program multicellular self-organization.

Satoshi Toda, Jonathan M Brunger, Wendell A Lim*. 

Current Opinion in Systems Biology. 14, 41–49 (2019) (Review)

2018

• Programming self-organizing multi-cellular structures with synthetic cell-cell signaling.

Satoshi Toda, Lucas R Blauch, Sindy KY Tang, Leonardo Morsut*, Wendell A Lim*. 

Science. 361, 156-162 (2018), Press release, Human Frontier Science Program NEWS & EVENTS

Featured in Tordoff J, Weiss R. "Self-organizing multicellular structures designed using synthetic biology." Nature. 559, 184-185 (2018). 

2015

• Clearance of Apoptotic Cells and Pyrenocytes.

Satoshi Toda, Chihiro Nishi, Yuichi Yanagihashi, Katsumori Segawa, Shigekazu Nagata*. 

Curr. Top. Dev. Biol. 114, 267-295 (2015) (Review)

2014

• MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands.

Satoshi Toda, Katsumori Segawa, Shigekazu Nagata*.

Blood. 123, 3963-3971 (2014), Highlighted as a cover of issue. 

Featured in McGrath KE. "Red cell island dances: switching hands." Blood. 123, 3847-3848 (2014).

• Tim4- and MerTK- mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages.

Chihiro Nishi, Satoshi Toda, Katsumori Segawa, Shigekazu Nagata*. 

Mol. Cell Biol. 34, 1512-1520 (2014)

2012

• Two-step engulfment of apoptotic cells.

Satoshi Toda, Rikinari Hanayama, Shigekazu Nagata*. 

Mol. Cell Biol. 32, 118-125 (2012)

Patent 特許

• Binding-triggered transcriptional switches and methods of use thereof

Wendell A. Lim, Leonardo Morsut, Kole T. Roybal, Justin Thomas Farlow, Satoshi Toda

Patent No.: US 10,590,182 B2.

Japanese articles 和文総説

• 戸田 聡 「人工受容体技術が変革するCAR-T細胞医薬のデザイン」実験医学, 41巻, 18号, 2023年

• 戸田 聡 「細胞間相互作用の再構成による多細胞構造の形成」生体の科学, Vol.73, No.4, 2022年8月号

• 水野 皓介、戸田 聡 「人工モルフォゲンによる多細胞パターンのデザイン」月刊「細胞」, Vol.53, No.10, 2021年9月号

• 戸田 聡, Wendell A. Lim 「細胞分化パターンの操作を可能とする人工モルフォゲンシステムの開発」実験医学, 39巻, 6号, 2021年

• 戸田 聡 「人工受容体技術を用いた細胞医薬のデザイン」実験医学増刊号, 38巻, 17号, 2020年

• 戸田 聡 「自己組織化により生じる多細胞からなる構造の人工的な形成」生物物理, 59巻, 3号, 2019年

• 戸田 聡 「人工のタンパク質回路を自在に設計して細胞の操作をめざす」実験医学, 37巻, 8号, 2019年

• 戸田 聡, Leonardo Morsut, Wendell A. Lim 「自己組織化により生じる多細胞からなる構造を人工的に作製する」実験医学, 36巻, 18号, 2018年

Japanese essays 和文エッセイ

• 戸田 聡 「生き物らしさの合成を目指して」学術変革領域(A)「多細胞生命自律性」ニュースレター, vol.1, No.2, 2022年