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Designed structure modulators for studying photosystem´s conformational dynamics. In natural photosystems, conformational changes regulate chromophore energy states, which are crucial for key functions. Specific protein-chromophore interactions might have a role in boosting these backbone changes, but a scant understanding of their nature leads to an underestimation of their role. Our research focuses on developing biohybrids with well-defined conformations by incorporating engineered structural modulators that directly interact with the protein backbone. We assess their impact by analyzing the folding landscapes of the biohybrids, the rotational freedom of photoactive molecules, and protein backbone dynamics. Using these insights, we create biophysical models to elucidate the mechanism of structural modulators and their role in tuning chromophore function.