We explore how amino acids shape the photoresponse of biohybrids by investigating their specific roles within these systems. Our research focuses on uncovering fundamental principles and developing innovative strategies for biohybrid design. Learn more about our key approaches below.
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GENERAL APPROACH
Simplifying the complexity
MAIN RESEARCH LINES
Designed structure modulators for studying photosystem´s conformational dynamics. In natural photosystems, conformational changes regulate chromophore energy states, which are crucial for key functions. Specific protein-chromophore interactions might have a role in boosting these backbone changes, but a scant understanding of their nature leads to an underestimation of their role. Our research focuses on developing biohybrids with well-defined conformations by incorporating engineered structural modulators that directly interact with the protein backbone. We assess their impact by analyzing the folding landscapes of the biohybrids, the rotational freedom of photoactive molecules, and protein backbone dynamics. Using these insights, we create biophysical models to elucidate the mechanism of structural modulators and their role in tuning chromophore function.
Engineered protein environments and their effects in the excited state relaxation of chromophores. In natural systems, key amino acids play a crucial role in modulating photoresponse. To understand this process, we investigate how they influence chromophore excited-state decay. We design modified biohybrids and track chromophore excited-state dynamics over time. These studies provide mechanistic insights into how amino acids shape chromophore energy patterns.
Selective light harvesting for applications. Our last research line is focused on developing proof-of-concepts to show the potential of optimized biohybrids in nanotechnological and photonic applications.
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