Research Papers

1. Singh AK, Kumar P, Mishra SK, Rajput VD, Tiwari KN, Singh AK, Minkina T, Pandey AK, Upadhyay P. A Dual Therapeutic Approach to Diabetes Mellitus via Bioactive Phytochemicals Found in a Poly Herbal Extract by Restoration of Favorable Gut Flora and Related Short-Chain Fatty Acids. Appl Biochem Biotechnol. 2024. Feb 23. 

2. Upadhyay P, Kalra D, Nilakhe AS, Aggrawal V, Gupta S. Polyherbal Formulation PL02 Alleviates Pain, Inflammation, and Subchondral Bone Deterioration in an Osteoarthritis Rodent Model. Front. Nutr 2023. 10:1217051. 

3. Upadhyay P, Tyagi A, Agrawal S, Kumar A, Gupta S. Bidirectional effect of Triphala on modulating Gut-brain axis to improve cognition in the Murine Model of Alzheimer’s disease. Mol Nutr Food Res. 2023 Sep 28:e2300104.

4.  Upadhyay P, Gupta S. Dual mode of Triphala in the reversal of cognition through gut restoration in antibiotic-mediated prolonged dysbiosis condition in 5XFAD mice. Experimental Neurology (2023).114473 

5. Mishra SK, Sinha S, Singh AK, Upadhyay P, et al. Green Synthesis, Characterization, and Application of Ascophyllum Nodosum Silver Nanoparticles. Regenerative Engineering and Translational Medicine (2023) 10.1007/s40883-023-00298-x 

6. Khandelwal M, Manglani K, Upadhyay P , Azad M, Gupta S. AdipoRon induces AMPK activation and ameliorates Alzheimer's like pathologies and associated cognitive impairment in APP/PS1 mice. Neurobiol Dis. 2022; 174:105876. 

7. Singh Y P, Shankar G, Jahan S, Singh G, Kumar N, Barik A, Upadhyay P, Singh L, Kamble K, Singh GK, Tiwari S, Garg P, Gupta S, Modi G. Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer’s disease. Bioorg Med Chem. 2021; 46:116385. 

8. Upadhyay P, Shukla R, Tiwari KN, Dubey GP, Mishra SK. Neuroprotective effect of Reinwardtia indica against scopolamine-induced memory impairment in the rat by attenuating oxidative stress. Metab Brain Dis. 2020 Jun; 35(5):709-725. 

9. Upadhyay P, Shukla R, Mishra SK. Acute and sub-acute toxicity assessment of the hydroalcoholic leaves extracts of Reinwardtia indica in rats. Biomedicine & Pharmacotherapy, 2019 111, 36–41. 

10. Upadhyay P, Mishra SK, Mishra A, Kumar P, Tiwari KN, Dubey GP, Purohit S, Pandey N and Tilak R. Evaluation of antioxidant and antimicrobial potential of a novel Himalayan plant Reinwardtia indica Dumort: Scientifically unexplored. Microbial Pathogenesis, 2019, 127, 326–334. 

11. Upadhyay P, Mishra SK, Dubey GP, Tiwari KN, Purohit S, Chauhan BS, Srikrishna S. Antioxidant, the anti-microbial and cytotoxic potential of silver nanoparticles synthesized using flavonoid rich alcoholic leaves extract of Reinwardtia indica. Drug and Chemical Toxicology, 2019, 42 (1), 65-75. 

12. Upadhyay P, Sadhu A, Singh PK, Purohit S, Shivakumar S, Agrawal A, Ilango K, Dubey GP. Revalidation of the Neuroprotective effects of a United States Patented polyherbal formulation on scopolamine-induced learning and memory impairment in Rats. Biomedicine & Pharmacotherapy, 2017,97,1046-1052. 

13. Mishra AK, Upadhyay P, Dixit J, Kumar P, Tiwari KN, Mishra SK, More R, Singh J Ameliorative Activity of Ethanolic Flower Extract of Nyctanthes arbor-tristis (L.) against Scopolamine-Induced Amnestic Effect and Profiling of Active Compounds Using Gas Chromatography-Mass Spectrometry and Ultra-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry. Pharmacognosy magazine, 2018, 14 (59), 596-604. 

14. Sadhu A, Upadhyay P, Agrawal A, Ilango K, Karmakar D, Singh GPI, Dubey GP. Management of cognitive determinants in senile dementia of Alzheimer’s Type: Therapeutic potential of a novel polyherbal drug Product. Clinical Drug Investigation, 2014, 34 (12) 857-869.

15. Sadhu A, Upadhyay P, Singh PK, Agrawal A, Ilango K, Karmakar D, Singh GPI, Dubey GP. Quantitative analysis of heavy metals in medicinal plants collected from environmentally diverse locations in India for use in a novel phytopharmaceutical product. Environ Monit Assess, 2015, 187,542.

Conferences

1. 1. Prabhat Upadhyay*, Ashutosh Yadav “Investigation of anticonvulsant effect of DHPM-5 in strychnine induced model in mice in 5th NIPER (RBL)- CDRI symposium on chemical and biological approaches in drug development  and delivery strategies, CDRI Lucknow India, March 2013

   2. Prabhat Upadhyay*, Aruna Agrawal, G P Dubey, Purohit S. Pharmacognostical, phytochemical and antimicrobial studies on the leaves and stems of Reinwardtia indica Dummort at 104th Indian Science Congress organized by SV University Tirupati, Jan 2017

   3. Prabhat Upadhyay*, Sunil Kumar Mishra, and G P Dubey. Phytochemical and pharmacology study of Reinwardtia indica at World Congress of Ayurveda organized by Faculty of Ayurveda, IMS, BHU March 2019

   4.  Ibrar Ahmed Sidiqqui, Prabhat Upadhyay* and Sarika Gupta, SG001-disease modifying drug: a new hope for the treatment of Alzheimer’s Disease at Global Bio-India 2019, Organized by DBT, BIBCOL, and BIRAC Aerocity, near IGI Airport, New Delhi India Nov 2019

   5. Prabhat Upadhyay*, Brijesh Bhayana, and Mei X Wu. Dual effect of low-level light on mitochondria biogenesis and gut homeostasis in anaerobic high intense exercise at Military Health System Research Symposium (MHSRS) August 2023 at the Gaylord Palms Resort and Convention Center, Kissimmee, FL USA

                                                                                                                                                                                                                                                *Presenter