We are studying the molecular basis of Antimicrobial Resistance (AMR) and searching for new drug targets against AMR. We are investigating the mechanisms of action of an essential bacterial GTPase, CgtA (Obg), which could serve as a new drug target against AMR in various bacteria. For this, we are applying bacterial genetics, molecular biology, biochemistry, microbiology, structural biology, and various computational tools. We also study bacterial stress responses and biofilm formation. Furthermore, we are investigating the action mechanisms of several novel proteins recently identified in our laboratory and are also working to develop anti-bacterial vaccines through collaborations. Vibrio, Mycobacteria, and Pseudomonas are some of our model organisms. 

On the other hand, we are conducting structure-function studies (cryo-EM) on certain plant viruses that cause significant economic losses in India and globally. We are also conducting cryo-EM studies on ribosomes and some other molecular complexes. 

Schematics of a single-particle cryo-EM workflow.  Reference: A Passage Through the Ribosome by Cryo-EM. Datta, P.P., Chatterjee, A. In: Dinman, J. (eds) Biophysical approaches to translational control of gene expression. Biophysics for the Life Sciences. (2012). vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3991-2_2 

                                                                  cryo-EM structure of  bacterial translation apparatus, i.e., the ribosome  (unpublished work)