We are studying the molecular basis of Antimicrobial Resistance (AMR) and searching for new drug targets against AMR. We are investigating the action mechanisms of an essential bacterial GTPase protein, CgtA (Obg), which could serve as a new drug target against AMR in various bacteria. For this, we use multiple molecular biological, biochemical, microbiological, structural biological, and computational tools. We are studying several bacteria, such as Mycobacteria, Vibrio, and Pseudomonas. Furthermore, we are investigating the action mechanisms of several novel proteins recently identified in our laboratory.
On the other hand, we are conducting structure-function studies (cryo-EM) on certain plant viruses that cause significant economic losses in India and globally. We are also doing cryo-EM studies on some other molecular complexes as well.