Publications

Publications by Dr. Ranea-Robles during PhD and postdoc

1. Merrild C; Johansen VBI;, Clemmensen C; Ranea-Robles, P. (4/4; CA). 2025. Sex-specific metabolic responses to modulation of the glucagon-FGF21 axis in female mice. bioRxiv. https://doi.org/10.1101/2025.04.09.647697.

2. Ranea-Robles P, Lund C, Svendsen C, Gil C, Lund J, Kleinert M, Clemmensen C. (1/7)  Time-resolved effects of short-term overfeeding on energy balance in mice. Diabetes 2025; db240289. https://doi.org/10.2337/db24-0289

3. Lund C and Ranea-Robles P*, Falk S, Belmont-Rausch D, Skovbjerg G, Kamma Vibe-Petersen V, Krauth N, Lercke Skytte J, Vana V, Roostalu U, Pers TH, Lund J, Clemmensen C (2/13). Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R. Nature Communications. 2024. Feb 8;15(1):1192. doi: https://doi.org/10.1038/s41467-024-45223-0

*: Co-first authorship with Lund C

4. Ranea-Robles P, Pavlova NN, Bender A, Pereyra AS, Ellis JM, Stauffer B, Yu C, Thompson CB, Argmann C, Puchowicz M, Houten SM (1/11). A mitochondrial long-chain fatty acid oxidation defect leads to transfer RNA uncharging and activation of the integrated stress response in the mouse heart. Cardiovascular Research. 2022. 118(16):3198-3210. doi: 10.1093/cvr/cvac050

Highlighted in: Dudek J, Bertero E, Maack C. The integrated stress response to the rescue of the starved heart. Cardiovasc Res. 2022. 118(16):3166-3168. doi: 10.1093/cvr/cvac141. PMID: 35994244.

5. Ranea-Robles P, Chen H, Stauffer B, Yu C, Bhattacharya D, Friedman SL, Puchowicz M, Houten SM (1/8) The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis. J Inherit Metab Dis. 2021 Nov;44(6):1419-1433. doi: 10.1002/jimd.12440.

Highlighted in JIMD podcast: https://soundcloud.com/user-109006120/easy-as-abcd3

6. Ranea-Robles P,  Portman K, Bender A, Lee K, He JC, Mulholland DJ, Argmann C, Houten SM (1/8). Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice. Kidney360. 2021 Sep;2(9):1441-1454. doi: 10.34067/KID.0003772021

7. Ranea-Robles P, Violante S, Argmann C, Dodatko T, Bhattacharya D, Chen H, Yu C, Friedman SL, Puchowicz M, Houten SM (1/11). Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis. Cell Mol Life Sci. 2021 Jul;78(14):5631-5646. doi: 10.1007/s00018-021-03869-9.

8. Ranea-Robles P, Galino J, Espinosa L, Schlüter A, Ruiz M, Calingasan NY, Villarroya F, Naudí A, Pamplona R, Ferrer I, Beal MF, Portero-Otín M, Fourcade S and Pujol A (1/14). Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model. Neuropathol Appl Neurobiol. 2022 Feb; 48(1):e12747 doi: 10.1111/nan.12747. Epub 2021 Jul 29.

9. Ranea-Robles P, Yu C, van Vlies N, Vaz FM, Houten SM (1/5). Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse. J Inherit Metab Dis. 2020. 43(3): 486-495. doi: 10.1002/jimd.12204.

10. Ranea-Robles P, Launay N, Ruiz M, Calingasan NY, Dumont M, Naudí A, Portero-Otín M, Pamplona R, Ferrer I, Beal MF, Fourcade S, Pujol A (1/12). Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy. EMBO Mol Med. 2018. 10(8):e8604. doi: 10.15252/emmm.201708604

11. Ranea-Robles P, Houten SM (1/2). The biochemistry and physiology of long-chain dicarboxylic acid metabolism. Biochemical Journal. 2023. 480(9):607-627. doi: 10.1042/BCJ20230041.

12. Ranea-Robles P, Lund J, Clemmensen C (1/3). The physiology of experimental overfeeding in animals. Molecular Metabolism. 2022. Volume 64, October 2022, 101573. doi: 10.1016/j.molmet.2022.101573

13. Houten SM, Wanders RJ, Ranea-Robles P (3/3). Metabolic interactions between peroxisomes and mitochondria with a special focus on acylcarnitine metabolism. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2020. 1866(5):165720. doi: 10.1016/j.bbadis.2020.165720. (https://hdl.handle.net/10481/100500)

14. Holm SK, Johansen VBI, Ranea-Robles P, Svendsen C, Merrild C, Rohlfs R, Lo Conte M, Hogendorf WFJ, Merkestein M, Zaykov AN, Fritzen AM, Mani BK, Clemmensen C (3/13). Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice. Diabetes. 2025 Jul 1:db241056. doi: 10.2337/db24-1056. Epub ahead of print. PMID: 40590720. 

15. Bender A, Ranea-Robles P, Williams EG, Mirzaian M, Heimel JA, Levelt CN, Wanders RJ, Aerts JM, Zhu J, Auwerx J, Houten SM, Argmann CA (2/12). A Multiomic Network Approach to Uncover Disease Modifying Mechanisms of Inborn Errors of Metabolism. J Inherit Metab Dis. 2025 Jul;48(4):e70045. doi: 10.1002/jimd.70045. PMID: 40443299; PMCID: PMC12129342.

16. Gil CRE, Lund J, Żylicz JJ, Ranea-Robles P, Sørensen TIA, Clemmensen C (4/6). Food insecurity promotes adiposity in mice. Obesity. 2025; 1-14. doi:10.1002/oby.24259

17. Jonas Petersen, Mette Q. Ludwig, Vaida Juozaityte, Pablo Ranea-Robles, Charlotte Svendsen, Eunsang Hwang, Amalie W. Kristensen, Nicole Fadahunsi, Jens Lund, Alberte W. Breum, Cecilie V. Mathiesen, Luisa Sachs, Roger Moreno-Justicia, Rebecca Rohlfs, James C. Ford, Jonathan D. Douros, Brian Finan, Bryan Portillo, Kyle Grose, Jacob E. Petersen, Mette Trauelsen, Annette Feuchtinger, Richard D. DiMarchi, Thue W. Schwartz, Atul S. Desmukh, Morten B. Thomsen, Kristi A. Kohlmeier, Kevin W. Williams, Tune H. Pers, Bente Frølund, Kristian Strømgaard, Anders B. Klein, Christoffer Clemmensen (4/33). GLP-1 directed NMDA receptor antagonism for obesity treatment. Nature. 2024. May;629(8014):1133-1141. doi: https://doi.org/10.1038/s41586-024-07419-8

Highlighted in: Tysoe, O. NMDA receptor antagonist coupled to GLP1 analogue in highly effective experimental weight loss drug. Nat Rev Endocrinol 20, 446 (2024). https://doi.org/10.1038/s41574-024-01007-6

Highlighted in: Dual-action obesity drug rewires brain circuits for appetite. Nature 629, 1011-1012 (2024) doi: https://doi.org/10.1038/d41586-024-01352-6

18. Klein AB, Ranea-Robles P, Nicolaisen TS, Gil C, Johann K, Prats Quesada, J, Pistolevij N, Hviid KVR, Olsen LF, Offersen SM, Helge JW, Svarre-Nielsen H, Bakker J, Kleinert M, Clemmensen C (2/15). Cross-species comparison of pregnancy-induced GDF15. American Journal of Physiology-Endocrinology and Metabolism. 2023. 325:4, E303-E309 doi: https://doi.org/10.1152/ajpendo.00134.2023. 

19. Lund J, Breum A, Gil C, Falk S, Sass F, Isidor M, Dmytriyeva O, Ranea-Robles P, Mathiesen C, Basse A, Johansen O, Fadahunsi N, Lund C, Nicolaisen T, Klein A, Ma T, Emanuelli B, Kleinert M, Sørensen C, Gerhart-Hines Z, Clemmensen C (8/21). The anorectic and thermogenic effects of pharmacological lactate are largely driven by overlooked confounding factors. Nat Metab. 2023. 5, 677–698. https://doi.org/10.1038/s42255-023-00780-4

Highlighted in: Lowe D. A lactate illusion. Science Blogs. 2023. https://www.science.org/content/blog-post/lactate-illusion

20. Diekman E, van Weeghel M, Suárez-Fariñas M, Argmann C, Ranea-Robles P, Wanders R, Visser G, van der Made I, Creemers E, Houten S (5/10). Dietary restriction in the long-chain acyl-CoA dehydrogenase knockout mouse. Mol Genet Metab Rep. 2021 Mar 30;27:100749. doi: 10.1016/j.ymgmr.2021.100749.

21. Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A (4/16). Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathol. 2018. 28(5):611-630. doi: 10.1111/bpa.12571