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She currently serves as president of the International Association of Contact Lens Educators and is a past president of the International Society for Contact Lens Research.Another important pioneer in the quest for oxygen, Hikaru Hamano, M.D., is a legend in his home country [ CONTACT LENS CARE SYSTEMS ] continued from page 11Alcon, and Bausch & Lomb. These were mostly simple disinfectants, preserved with a combination of chlorhexidine and thimerosol, benzalkonium chloride (BAK) and other preservatives, and were used with hard lenses. Consumers still needed to use saline solution along with the cleaner.The second generation of soft lens care products would encompass hydrogen peroxide cleaners such as AOSept, originally from American Optical Company and later acquired by CIBA Vision. Additionally, enzymatic cleaning products were developed to remove protein deposits on the lenses. Pioneers in this endeavor included Hemper Karagosian at Allergan and Kiran Randiri, Ph.D., at Alcon. The early peroxide systems were popular in the early 1980s12 |with the increasing incidence of allergic reactions related to thimerosol and chlorhexidine. With patients not replacing lenses for long periods, enzyme cleaning was a necessity,although these products remained largely peripheral.In the mid- to late 1980s, scientists introduced the next generation of disinfectants, using polyhexamethylene biguanide (PHMB) and Polyquad preservatives. These included Alcon’s OptiFree line and Bausch & Lomb’s ReNu (developed by Dr. Randiri; Lai Ogunbiyi, Pharm. D.; Frank Smith, Ph.D.; Tom Reidhammer, Ph.D.; Dr. Stone and others). These products were originally approved and marketed as disinfectants only with separate cleaners; a few years later, they would cross over into the multipurpose solution category.By this time, earlier problems with lens-solution interactions had been resolved through an FDA-initiated lens classification system that Dr. Stone helped craft. First published in 1985, the new system classified lenses accordingcontinued on page 16 1972Dr. Korb patents the CSI Lens, the first ultrathinnon-HEMA soft lens.of Japan. In the early 1970s, Dr. Hamano was the first in the world to demonstrate the partial oxygen pressure on the cornea underDr. Hamano’s experiment (1978).
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