主持人

Publications

I. 醫學研究

1. Wu CC, Brugeaud A, Seist R, Lin HC, Yeh WH, Petrillo M, Coppola G, Edge ASB, Stankovic KM. Altered expression of genes regulating inflammation and synaptogenesis during regrowth of afferent neurons to cochlear hair cells. PLoS One. 2020;15:e0238578.

2. Cheng YF, Tsai YH, Huang CY, Lee YS, Lu YC*, Hsu CJ*, Wu CC*. Generation and pathological characterization of a transgenic mouse model carrying a missense PJVK mutation. BBRC. 2020;532:675-681. (* corresponding authors)

3. Hu CJ, Lu YC, Tsai YH, Cheng HY, Takeda H, Huang CY, Xiao R, Hsu CJ, Tsai JW, Vandenberghe L, Wu CC, Cheng YF. Efficient in utero gene transfer to the mammalian inner ears by a synthetic adeno-associated viral vector Anc80L65. Mol Ther Methods Clin Dev. 2020;18:493-500.

4. Lin PH, Hsu CJ, Lin YH, Lin YH, Yang SY, Yang TH, Chen PL, Wu CC*, Liu TC*. An integrative approach for pediatric auditory neuropathy spectrum disorders: revisiting etiologies and exploring the prognostic utility of auditory steady-state response. Sci Rep. in press (* corresponding authors)

5. Huang CY, Tsai YH, Tsai YC, Lu YC, Chan YH, Hsu CJ, Chiou SH, Wu CC*, Cheng YF*. Establishment of an induced pluripotent stem cell (iPSC) line from a 7-year-old male patient with profound hearing loss carrying c.235delC in GJB2 gene. Stem Cell Res. 2020;45:101795. (* corresponding authors)

6. Yu RB, Lu TC, Wu CC, Liu TC, Chen JW. Endoscopic Resection of Middle-Ear Lymphatic Malformation in a Child. Ear Nose Throat J. 2020 Mar 5:145561320908475.

7. Chen PY, Lin YH, Liu TC, Lin YH, Tseng LH, Yang TH, Chen PL, Wu CC*, Hsu CJ. Prediction model for audiological outcomes in patients with GJB2 mutations. Ear Hear. 2020;41:143-149. (* corresponding author)

8. Chan YH, Liu TC, Liao CK, Cheng YF, Tsai CH, Lu YC, Hu CJ, Lin HJ, Lee YL, Wu CC*, CJ Hsu. Consumption of betel quid contributes to sensorineural hearing impairment through arecoline-induced oxidative stress. Sci Rep. 2019;9:14554. (* corresponding author)

9. Wu CC, Tsai CY, Lin YH, Chen PY, Lin PH, Cheng YF, Wu CM, Lin YH, Lee CY, Erdenechuluun J, Liu TC, Chen PL, Hsu CJ. Genes. 2019;10(10).

10. Cheng YF, Chan YH, Hu CJ, Lu YC, Saeki T, Hosoya M, Saegusa C, Fujioka M, Okano H, Weng SM, Hsu CJ, Chang KH*, Wu CC*. Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation. Stem Cell Res. 2019;40:101524. (* corresponding authors)

11. Tang TH, Hwang JH, Yang TH, Hsu CJ, Wu CC*, Liu TC*. Can Nutritional Intervention for Obesity and Comorbidities Slow Down Age-Related Hearing Impairment? Nutrients. 2019;11(7). (* corresponding authors)

12. Lin YH*, Wu CC*, Lin YH, Lu YC, Chen CS, Liu TC, Chen CY, Chen PL, Hsu CJ. Targeted next-generation sequencing facilitates genetic diagnosis and provides novel pathogenetic insights into deafness with enlarged vestibular aqueduct. J Mol Diagn. 2019;21:138-148. (* Equal contribution as first author)

13. Erdenechuluun J, Lin YH, Ganbat K, Bataakhuu D, Makhbal Z, Tsai CY, Lin YH, Chan YH, Hsu CJ, Hsu WC, Chen PL, Wu CC*. Unique spectra of deafness-associated mutations in Mongolians provide insights into the genetic relationships among Eurasian populations. PLoS One. 2018;13:e0209797. (* corresponding author)

14. Hsieh MC, Wu CC, Wang SH. Lateral semicircular canal dehiscence with positive perilymph fistula test. CMAJ. 2018. 191:E104.

15. Chan YH, Cheng YF, Chen YT, Huang CY, Lin CH, Hu CJ, Lu YC, Wu CC*, Hsu CJ*. Generation of induced pluripotent stem cells from a patient with hearing loss carrying GJB2 p.V37I mutation. Stem Cell Res. 2018;33:51-55.

16. Lu CY, Tsao PN, Ke YY, Lin YH, Lin YH, Hung CC, Su YN, Hsu WC, Hsieh WS, Huang LM, Wu CC*, Hsu CJ. Concurrent hearing, genetic, and cytomegalovirus screening in newborns, Taiwan. J Pediatr. 2018;199:144-150. (* corresponding author)

17. Chen YH, Liu TC, Yang TH, Lin KN, Wu CC*, Hsu CJ. Using endoscopy to locate the round window membrane during cochlear implantation: Our experience with 25 patients. Clin Otolaryngol. 2018;43:357-362. (* corresponding author)

18. Wu CC, Hsu CJ, Huang FL, Lin YH, Lin YH, Liu TC, Wu CM. Timing of cochlear implantation in auditory neuropathy patients with OTOF mutations: Our experiences with 10 patients. Clin Otolaryngol. 2018;43:352-357.

19. Lin PH, Hsu CJ, Lin YH, Lin YH, Lee HY, Wu CC*, Liu TC. Etiologic and audiologic characteristics of patients with pediatric-onset unilateral and asymmetric sensorineural hearing loss. JAMA Otolaryngol Head Neck Surg. 2017;143:912-919. (* Corresponding author)

20. Lin YH, Lin YH, Lu YC, Liu TC, Chen CY, Hsu CJ*, Chen PL*, Wu CC*. A novel missense variant in the nuclear localization signal of POU4F3 causes autosomal dominant non-syndromic hearing loss. Sci Rep. 2017;7:7551. (* corresponding authors)

21. Wu CC, Chen YH, Yang TH, Lin KN, Lee SY, Liu TC, Hsu CJ. Endoscopic versus microscopic management of congenital ossicular chain anomalies: Our experiences with 29 patients. Clin Otolaryngol. 2017;42:944-950.

22. Wu CC, Tsai CH, Hung CC, Lin YH, Lin YH, Huang FL, Tsao PN, Su YN, Lee YL, Hsieh WS, Hsu CJ. Newborn genetic screening for hearing impairment: a population-based longitudinal study. Genet Med. 2017;19:6-12.

23. Wu CM, Ko HC, Tsou YT, Lin YH, Lin JL, Chen CK, Chen PL, Wu CC*. Long-term cochlear implant outcomes in children with GJB2 and SLC26A4 mutations. PLoS One. 2015;10:e0138575. (* Corresponding author)

24. Wu CC, Lin YH, Liu TC, Lin KN, Yang WS, Hsu CJ, Chen PL, Wu CM. Identifying children with poor cochlear implantation outcomes using massively parallel sequencing. Medicine. 2015;94:e1073.

25. Wu CC, Tsai CH, Lu YC, Lin HC, Hwang JH, Lin YH, Yang WS, Chen PJ, Liao WC, Lee YL, Liu TC, Hsu CJ. Contribution of adiponectin and its type 1 receptor to age-related hearing impairment. Neurobiol Aging.2015;36:2085-93.

26. Lin YH, Wu CC, Hsu TY, Chiu WY, Hsu CJ, Chen PL. Identification of a novel GATA3 mutation in a deaf Taiwanese family by massively parallel sequencing. Mutat Res. 2015;771:1-5.

27. Chen PY, Wu CC, Yang TL, Hsu CJ, Lin YT, Lin KN. Gradenigo syndrome caused by nontuberculous mycobacteria. Audiol Neurotol. 2014;19:275-82..

28. Kandathil CK, Dilwali S, Wu CC, Ibrahimov M, McKenna MJ, Lee H, Stankovic KM. Aspirin intake correlates with halted growth of sporadic vestibular schwannoma in vivo. Otol Neurotol. 2014;35:353-7.

29. Hsu TY, Wu CC, Chang JG, Lee SY, Hsu CJ. In response to determinants of bilateral audiometric notches in noise-induced hearing loss. Laryngoscope. 2013;123:E130.

30. Lu YC, Wu CC*, Yang TH, Lin YH, Yu IS, Lin SH, Chang Q, Lin X, Wong JM, Hsu CJ. Differences in the pathogenicity of the p.H723R mutation of the common deafness-associated SLC26A4 gene in humans and mice. PLoS One. 2013;8:e64906. (* Equal contribution as first author)

31. Wu CC, Lin YH, Lu YC, Chen PJ, Yang WS, Hsu CJ, Chen PL. Application of massively parallel sequencing to genetic diagnosis in multiplex families with idiopathic sensorineural hearing impairment. PLoS One. 2013;8:e57369.

32. Hsu TY, Wu CC, Chang JG, Lee SY, Hsu CJ. Determinants of bilateral audiometric notches in noise-induced hearing loss. Laryngoscope. 2013;123:1005-10.

33. Hwang JH, Liu KS, Wu CC, Liu TC. Association of Cadherin23 single nucleotide polymorphism with age-related hearing impairment in Han Chinese. Otolaryngol Head Neck Surg. 2012;147:531-4.

34. Wang CP, Chen TZ, Chang YL, Ko JY, Yang TL, Lo FY, Hu YL, Chen PL, Wu CC*, Lou PJ*. Common genetic mutations in the start codon of the SDH subunit D gene among Chinese families with familial head and neck paragangliomas. Oral Oncology. 2012;48:125-9. (* Corresponding authors)

35. Wang SH, Wu CC, Lu YC, Lin YH, Su YN, Hwu WL, Yu IS, Hsu CJ. Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome. Laryngoscope. 2012;122:1130-6.

36. Wu CC, Hung CC, Lin SY, Hsieh WS, Tsao PN, Lee CN, Su YN, Hsu CJ. Newborn genetic screening for hearing impairment: a preliminary study in a tertiary center. PLoS One. 2011;6:e22314.

37. Lu YC, Wu CC*, Shen WS, Yang TH, Yeh TH, Chen PJ, Yu IS, Lin SH, Wong JM, Chang Q, Lin X, Hsu CJ. Establishment of a knock-in mouse model with the SLC26A4 c.919-2A>G mutation and characterization of its pathology. PLoS One. 2011;6:e22150. (* Equal contribution as first author)

38. Wu CC, Liu TC, Wang SH, Hsu CJ, Wu CM. Genetic characteristics in children with cochlear implants and the corresponding auditory performance. Laryngoscope. 2011;121:1287-93.

39. Lin YH, Wu CC, Hsu CJ, Hwang JH, Liu TC. The grainyhead like 2 gene (GRHL2) single nucleotide polymorphism is not associated with age-related hearing impairment in Han Chinese. Laryngoscope. 2011;121:1303-7.

40. Wu CC, Lin SY, Su YN, Fang MY, Chen SU, Hsu CJ. Pre-implantation genetic diagnosis (embryo screening) for enlarged vestibular aqueduct due to SLC26A4 mutation. Audiol Neurotol. 2010;15:311-7.

41. Chiu YS, Wu CC*, Lu YC, Chen PJ, Lee WY, Liu AYZ, Hsu CJ. Mutations of the OTOF gene in Taiwanese patients with auditory neuropathy. Audiol Neurotol. 2010;15:364-74. (* Equal contribution as first author)

42. Wu CC, Lu YC, Chen PJ, Yeh PL, Su YN, Hwu WL, Hsu CJ. Phenotypic analyses and mutation screening of the SLC26A4 and FOXI1 genes in 101 Taiwanese families with bilateral nonsyndromic enlarged vestibular aqueduct (DFNB4) or Pendred syndrome. Audiol Neurotol. 2010;15:57-66.

43. Wu CC, Lu YC, Chen PJ, Liu AYZ, Hwu WL, Hsu CJ. Application of SNaPshot^® multiplex assays for simultaneous multigene mutation screening in patients with idiopathic sensorineural hearing impairment. Laryngoscope. 2009;119:2411-6.

44. Hwang JH, Wu CC, Hsu CJ, Liu TC, Yang WS. Association of central obesity with the severity and audiometric configurations of age-related hearing impairment. Obesity. 2009;17:1796-801.

45. Wu CC, Lee YC, Chen PJ, Hsu CJ. Predominance of genetic diagnosis and imaging results as predictors in determining the speech perception performance outcome after cochlear implantation in children. Arch Ped Ado Med. 2008; 162:269-76. (= JAMA Pediatrics)

46. Wu CC, Lee SY, Hsu CJ, Yeh TH. Patients with positive allergen test have less favorable outcome after endoscopic microdebrider-assisted inferior turbinoplasty. Am J Rhinol. 2008;22:20-3.

47. Wu CC, Chen PJ, Chiu YH, Lu YC, Wu MC, Hsu CJ. Prospective mutation screening of three common deafness genes in a large Taiwanese cohort with idiopathic bilateral sensorineural hearing impairment reveals a difference in the results between families from hospitals and those from rehabilitation facilities. Audiol Neurotol. 2008;13:172-81.

48. Wu CC, Chiu YH, Chen PJ, Hsu CJ. Prevalence and clinical features of the mitochondrial m.1555A>G mutation in Taiwanese patients with idiopathic sensorineural hearing loss and association of haplogroup F with low penetrance in three families. Ear Hear. 2007;28:332-42.

49. Chu PL, Wu CC*, Hsu CJ, Wang YT, Wu KD. Potential oto-toxicity of aluminum in hemodialysis patients. Laryngoscope. 2007;117:137-41. (* Equal contribution as first author)

50. Wu CC, Yeh TH, Chen PJ, Hsu CJ. Prevalent SLC26A4 mutations in patients with enlarged vestibular aqueduct and/or Mondini’s dysplasia: a unique spectrum of mutations in Taiwan, including a frequent founder mutation. Laryngoscope. 2005;115:1060-4.

51. Wu CC, Chen PJ, Hsu CJ. Specificity of SLC26A4 gene mutations in the pathogenesis of inner ear malformations. Audiol Neurotol. 2005;10:234-42.

52. Wu CC, Chen YS, Chen PJ, Hsu CJ. Common clinical features of children with enlarged vestibular aqueduct and Mondini dysplasia. Laryngoscope. 2005;115:132-7.

53. Wu CC, Young YH, Ko JY. Effect of irradiation on vestibular evoked myogenic potentials in nasopharyngeal carcinoma survivors. Head Neck. 2003;25:482-7.

54. Wu CC, Young YH. Vestibular evoked myogenic potentials are intact after sudden deafness. Ear Hear. 2002;23:235-8.

55. Young YH, Wu CC, Wu CH. Augmentation of vestibular evoked myogenic potentials: an indication for distended saccular hydrops. Laryngoscope. 2002;112:509-12.

II. 法學學術論文