¶corresponding author, *equal contribution, O#: original articles, RE#: review articles or book chapters (in English)

Also see Google Scholar, PubMed, and ResearchGate.

Submitted/In revision

[101 / O#75] [Submitted] Hoshino R¶, XXX, Lin H-K, XXX, Ameku T, Tei T, XXX, XXX, XXX, Shimada-Niwa Y, XXX, XXX, XXX, Niwa R¶ (A seminal fluid protein in Drosophila) 

[100 / O#74] [Submitted] XXX¶, Abe M, Hoshino R, Mizuno Y, Kurogi Y, Imura E, XXX, XXX, Niwa R¶, XXX¶ (A novel hormone regulating nutritional homeostasis)

[99 / RE#26] [Submitted] Kurogi Y, Niwa R¶ (A review manuscript of JH-dependent regulation of insect reproduction)

[98 / RE#25] [In revision] Mizuno Y, Niwa R¶ (A review manuscript of hormonal regulation of insect reproduction)

Preprint

[97 / O#73] Watanabe A, Koyama T, Kubrak O, Texada MJ, Furumitsu M, Iwakoshi-Ukena E, Maxson R, Yoshii T, Kondo S, Yamanaka N, Ukena K, Rewitz K, Niwa R, Okamoto N¶ (2025) Ion transport peptide regulates body water balance via a receptor guanylyl cyclase in the Drosophila hindgut. bioRxiv DOI:10.1101/2025.10.24.684309

[96 / O#72] Shi D, Shimada-Niwa Y¶, Okamoto N, Nakamura A, Ohhara Y, Sun W¶, Niwa R¶ (2025) NudC moonlights in ribosome biogenesis and homeostasis in Drosophila melanogaster polyploid cells. bioRxiv DOI:10.1101/2025.09.14.675990

[95 / O#71] [In revision] Qian Q¶, Nagai H, Sanaki Y, Hayashi M, Kimura K, Nakajima Y, Niwa R¶ (2025) Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut. bioRxiv DOI:10.1101/2025.07.05.662934

2025

[94 / O#70] Okamoto N¶, Mizuno Y, Watanabe A, Kohsaka H, Niwa R¶ Neuroendocrine control of calcium mobilization in the fruit fly. Nature DOI:10.1038/s41586-025-09670-z

[93 / O#69] Matsumura T¶, Ryuda M, Matsumoto H, Kamiyama T, Jinnai K, Kondo S, Nakamura A, Hayakawa Y, Niwa R¶ (2025) Stress-induced organismal death is genetically regulated by the mTOR-Zeste-Phae1 axis. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 122:e242701412. DOI:10.1073/pnas.2427014122

[92 / RE#24] Niwa R¶, Niwa YS (2025) Molecular mechanisms of ecdysteroid biosynthesis. Reference Module in Life Sciences DOI:10.1016/B978-0-323-95424-2.00043-1

[91 / RE#23] Hayashi R, Niwa R¶ (2025) Large-scale omics analyses of nutrition-responsive mechanisms of female germline stem cell proliferation and maintenance in Drosophila melanogaster. Current Opinion in Insect Science 67:101296. DOI:10.1016/j.cois.2024.101296

[90 / O#68] Kamiyama T*, Shimada-Niwa Y*¶, Mori H, Tani N, Takemata-Kawabata H, Fujii M, Takasu A, Katayama M, Kuwabara T, Seike K, Matsuda-Imai N, Senda T, Katsuma S, Nakamura A, Niwa R¶ (2025) Parasitoid wasp venoms degrade Drosophila imaginal discs for successful parasitism. Science Advances 11:eadq8771. DOI:10.1126/sciadv.adq8771

2024

[89 / O#67] Yoshinari Y¶, Nishimura T¶, Yoshii T, Kondo S, Tanimoto H, Kobayashi T, Matsuyama M, Niwa R¶ (2024) A high-protein diet-responsive gut hormone regulates behavioural and metabolic optimization in Drosophila melanogaster. Nature Communications 15:10819. DOI:10.1038/s41467-024-55050-y

[88/ O#66] Kurogi Y, Mizuno Y, Hayashi R, Goyins K, Okamoto N, Barton L, Niwa R¶ (2024) The seminal vesicle is a juvenile hormone-responsive tissue in adult male Drosophila melanogaster. Open Biology 14:240315. DOI:10.1098/rsob.240315

[87 / O#65] Kim SJ, Lee KM, Park SH, Yang T, Song I, Rai F, Hoshino R, Yun M, Zhang C, Kim JI, Lee S, Suh GSB, Niwa R, Park ZY, Kim YJ¶ (2024) A sexually transmitted sugar orchestrates reproductive responses to nutritional stress. Nature Communications 15:8477. DOI:10.1038/s41467-024-52807-3

[86 / O#64] Šťastná K, Musdal Y, Ismail A, Ebihara K, Niwa R, Mannervik B¶ (2024) Supreme glutathione-dependent ketosteroid isomerase in the yellow-fever transmitting mosquito Aedes aegypti. Biochemical and Biophysical Research Communications. 711:149914. DOI: 10.1016/j.bbrc.2024.149914

[85 / O#63] Kurogi Y*, Mizuno Y*, Kamiyama T*, Niwa R¶ (2024) The intestinal stem cell/enteroblast-GAL4 driver, escargot-GAL4, also manipulates gene expression in the juvenile hormone-synthesizing organ of Drosophila melanogaster. Scientific Reports 14:9631 (DOI:10.1038/s41598-024-60269-2

2023

[84/ RE#22] Qian Q, Niwa R¶ (2023) Endocrine Regulation of Aging in the Fruit Fly Drosophila melanogaster. Zoological Science 41: 4-13. DOI:10.2108/zs230056.

[83/ O#62] Imura E¶, Enya S, Niwa R¶ (2023) A Drosophila melanogaster ortholog of pentatricopeptide repeat domain 3 (PTCD3) is essential for development. microPublication Biology DOI:10.17912/micropub.biology.000999.

[82 / O#61] Kato N*¶, Ebihara K*, Nogawa T, Futamura Y, Inaba K, Okano A, Aono H, Fujikawa Y, Inoue H, Matsuda K, Osada H, Niwa R, Takahashi S (2023) cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo. PLoS ONE 18:e0290851. DOI:10.1371/journal.pone.0290851

[81 / O#60] Kurogi Y, Imura E, Mizuno Y, Hoshino R, Nouzova M, Matsuyama S, Mizoguchi A, Kondo S, Tanimoto H, Noriega FG, Niwa R¶ (2023) Female reproductive dormancy in Drosophila melanogaster is regulated by DH31-producing neurons projecting into the corpus allatum. Development 150:dev201186. DOI:10.1242/dev.201186

[80 / RE#21] Niwa R¶, Sato M, Igaki T (2023) Editorial note: flying high in Japan. Fly 17:2173997. DOI:10.1080/19336934.2023.2173997

[79 / RE#20] Ebihara K, Niwa R¶ (2023) Compounds Inhibiting Noppera-bo, a Glutathione S-transferase Involved in Insect Ecdysteroid Biosynthesis: Novel Insect Growth Regulators. Biomolecules 13:461. DOI:10.3390/biom13030461

[78 / O#59] Hoshino R, Sano H, Yoshinari Y, Nishimura T, Niwa R¶ (2023) Circulating fructose regulates a germline stem cell increase via gustatory receptor–mediated gut hormone secretion in mated Drosophila. Science Advances 9:eadd5551. DOI:10.1126/sciadv.add5551

[77 / O#58] Komori Y*, Takayama K*, Okamoto N*, Kamiya M, Koizumi W, Ihara M, Misawa D, Kamiya, K, Yoshinari Y, Seike K, Kondo S, Tanimoto H, Niwa R, Sattelle DB, Matsuda K¶ (2023) Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors–targets of neonicotinoids. PLoS Genetics 19:e1010522. DOI:10.1371/journal.pgen.1010522

2022

[76 / O#57] Abe M, Kamiyama T, Izumi Y, Qian Q, Yoshihashi Y, Degawa Y, Watanabe K, Hattori Y, Uemura T, Niwa R¶ (2022) Shortened lifespan induced by a high-glucose diet is associated with intestinal immune dysfunction in Drosophila sechellia. Journal of Experimental Biology 13:jeb.244423. DOI: 10.1242/jeb.244423

[75 / O#56] Kosakamoto H, Okamoto N, Aikawa H, Sugiura Y, Suematsu M, Niwa R, Miura M, Obata F¶ (2022) Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila. Nature Metabolism 4:944-959. DOI:10.1038/s42255-022-00608-7

[74 / O#55] Kamiyama T, Shimada-Niwa Y¶, Tanaka H, Katayama M, Kuwabara T, Mori H, Itoh T, Toyoda T, Niwa R¶ (2022) Whole-genome sequencing analysis and protocol for RNA interference of the endoparasitoid wasp Asobara japonica. DNA Research 29: dsac019. DOI:10.1093/dnares/dsac019

[73 / RE#19] Yoshinari Y, Niwa R¶ (2022) Visualization of Mating-Dependent Activation of Neurons and Oogenesis in Drosophila melanogaster. In Neuromethods Book Series, Volume 181. DOI:10.1007/978-1-0716-2321-3_3

[72 / RE#18] Niwa YS¶, Niwa R (2022) Endocrinology: Non-insulin-producing cells secrete insulin under nutrient shortage. Current Biology 32:R380-R382. DOI:10.1016/j.cub.2022.03.003

[71 / O#54] Inaba K, Ebihara K, Senda M, Yoshino R, Sakuma C, Koiwai K, Takaya D, Watanabe C, Watanabe A, Kawashima Y, Fukuzawa K, Imamura R, Kojima H, Okabe T, Uemura N, Kasai S, Kanuka H, Nishimura T, Watanabe K, Inoue H, Fujikawa Y, Honma T, Hirokawa T, Senda T, Niwa R¶ (2022) Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti. BMC Biology 20:43. DOI: 10.1186/s12915-022-01233-2

[70 / RE#17] Kamiyama T, Niwa R¶ (2022) Transcriptional regulators of ecdysteroid biosynthetic enzymes and their roles in insect development. Frontiers in Physiology 13:823418. DOI: 10.3389/fphys.2022.823418

2021

[69 / RE#16] Hoshino R, Niwa R¶ (2021) Regulation of mating-induced increase in female germline stem cells in the fruit fly Drosophila melanogaster. Frontiers in Physiology 12:785435. DOI: 10.3389/fphys.2021.785435

[68 / RE#15] Kurogi Y, Mizuno Y, Imura E, Niwa R¶ (2021) Neuroendocrine regulation of reproductive dormancy in the fruit fly Drosophila melanogaster: A review of juvenile hormone-dependent regulation. Frontiers in Ecology and Evolution 9:715029. DOI: 10.3389/fevo.2021.715029

[67 / RE#14] Kamiyama T, Niwa R¶ (2021) Chapter 126A. 20-hydroxyecdysone. In Handbook of Hormones 2nd Edition. Elsevier. pp. 983-986. eBook ISBN: 9780128206508

[66 / RE#13] Kamiyama T, Niwa R¶ (2021) Chapter 126. Ecdysteroids. In Handbook of Hormones 2nd Edition. Elsevier. pp. 981-982. eBook ISBN: 9780128206508

[65 / O#53] Toyofuku M, Fujinaga D, Inaba K, Funahashi T, Fujikawa Y, Inoue H, Kataoka H, Niwa R, Ono H¶ (2021) The plant-derived triterpenoid, cucurbitacin B, but not cucurbitacin E, inhibits the developmental transition associated with ecdysone biosynthesis in Drosophila melanogaster. Journal of Insect Physiology 134: 104294. DOI: 10.1016/j.jinsphys.2021.104294

[64 /O#52] Yoshinari Y, Kosakamoto H, Kamiyama T, Hoshino R, Matsuoka R, Kondo S, Tanimoto H, Nakamura A, Obata F, Niwa R¶ (2021) The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster. Nature Communications 12: 4818. DOI: 10.1038/s41467-021-25146-w

[63 /O#51] Mizuno Y, Imura E, Kurogi Y, Shimada-Niwa Y, Kondo S, Tanimoto H, Hückesfeld S, Pankratz MJ, Niwa R¶ (2021) A population of neurons that produce hugin and express the diuretic hormone 44 receptor gene projects to the corpora allata in Drosophila melanogaster. Development, Growth, and Differentiation 63: 249-261. DOI: 10.1111/dgd.12733.

[62 / O#50] Koiwai K*, Morohashi K*, Inaba K, Ebihara K, Kojima H, Okabe T, Yoshino R, Hirokawa T, Nampo T, Fujikawa Y, Inoue H, Yumoto F, Senda T, Niwa R¶ (2021) Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo. Journal of Pesticide Science 46: 75-87. DOI:10.1584/jpestics.D20-072

2020

[61 / O#49] Seong KH¶, Matsumura T, Shimada-Niwa Y, Niwa R, Kang S¶ (2020) The Drosophila Individual Activity Monitoring and Detection System (DIAMonDS). eLife 9:e58630. DOI: 10.7554/eLife.58630

[60 / O#48] Yoshinari Y, Ameku T, Kondo S, Tanimoto H, Kuraishi T, Shimada-Niwa Y, Niwa R¶ (2020) Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster. eLife 9:e57101. DOI: 10.7554/eLife.57101

[59 / O#47] Ihara M, Furutani S, Shigetou S, Shimada S, Niki K, Komori Y, Kamiya M, Koizumi W, Magara L, Hikida M, Noguchi A, Okuhara D, Yoshinari Y, Kondo S, Tanimoto H, Niwa R, Sattelle DB, Matsuda K¶ (2020) Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions. Proceedings of National Academy of Science of the United States of America (PNAS) 117: 16283-16291. DOI:10.1073/pnas.2003667117

[58 / O#46] Kamiyama T, Sun W, Tani N, Nakamura A, Niwa R¶ (2020) Poly(A) Binding Protein is required for nuclear localization of the ecdysteroidogenic transcription factor Molting defective in the prothoracic gland of Drosophila melanogaster. Frontiers in Genetics 11: 636. DOI:10.3389/fgene.2020.00636

[57 / O#45] Imura E*, Shimada-Niwa Y*¶, Nishimura T, Hückesfeld S, Schlegel P, Ohhara Y, Kondo S, Tanimoto H, Cardona A, Pankratz MJ, Niwa R (2020) The Corazonin-PTTH Neuronal Axis Controls Systemic Body Growth by Regulating Basal Ecdysteroid Biosynthesis in Drosophila melanogaster. Current Biology 30: 1–10. DOI:10.1016/j.cub.2020.03.050 

[56 / O#44] Koiwai K*, Inaba K*, Morohashi K, Enya S, Arai R, Kojima H, Okabe T, Fujikawa Y, Inoue H, Yoshino R, Hirokawa T, Kato K, Fukuzawa K, Shimada-Niwa Y, Nakamura A, Yumoto F, Senda T, Niwa R¶ (2020) An integrated approach unravels a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo. Journal of Biological Chemistry 295: 7154-7167. DOI:10.1074/jbc.RA119.011463 

[55 / RE#12] Niwa R¶, Kai T (2020) Editorial overview: Stem cells orchestrate oogenesis: a lesson from the fruit fly, Drosophila melanogaster. Current Opinion in Insect Science 37: iii-v. DOI: 10.1016/j.cois.2020.0

[54 / RE#11] Hayashi Y¶, Yoshinari Y, Kobayashi S, Niwa R (2020) The regulation of Drosophila ovarian stem cell niches by signaling crosstalk. Current Opinion in Insect Science 37: 23-29. DOI: 10.1016/j.cois.2019.10.006

2019

[53 / RE#10] Yoshinari Y, Kurogi Y, Ameku T, Niwa R¶ (2019) Endocrine regulation of female germline stem cells in the fruit fly Drosophila melanogaster. Current Opinion in Insect Science 31: 14-19. DOI: 10.1016/j.cois.2018.07.001

2018

[52 / O#43] Zeng J, Kamiyama T, Niwa R, King-Jones K¶ (2018) The Drosophila CCR4-NOT complex is required for cholesterol homeostasis and steroid hormone synthesis. Developmental Biology 443: 10-18. DOI: 10.1016/j.ydbio.2018.08.012.

[51 / O#42] Ameku T, Yoshinari Y, Texada MJ, Amezawa K, Yoshizaki G, Shimada-Niwa Y, Niwa R¶ (2018) Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner. PLoS Biology 16: e2005004. DOI:10.1371/journal.pbio.2005004

[50 / O#41] Uryu O*, Ou Q*, Komura-Kawa T, Kamiyama T, Iga M, Syrzycka M, Hirota K, Kataoka H, Honda BM, King-Jones K¶, Niwa R¶ (2018) Cooperative Control of Ecdysone Biosynthesis in Drosophila by Transcription Factors Séance, Ouija board, and Molting Defective. Genetics 208: 605-622. DOI:10.1534/genetics.117.300268

[49 / RE#9] Niwa R¶ and Nishimura T (2018) Assembly of insect hormone enthusiasts at Nasu Highland, Japan: Report of the 3rd International Insect Hormone (21st Ecdysone) Workshop. Genes to Cells 23: 16-21. DOI:10.1111/gtc.12543

2017

[48 / O#40] Enya S*, Yamamoto C*, Mizuno H, Esaki T, Lin H-K, Iga M, Morohashi K, Hirano T, Kataoka H, Masujima H, Shimada-Niwa Y¶, Niwa R¶ (2017) Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During the Larval Development in Drosophila. Genetics 207: 1519-1532. DOI:10.1534/genetics.117.300391

[47 / O#39] Imura E*, Yoshinari Y*, Niwa YS*¶, Niwa R¶ (2017) Protocols for Visualizing Steroidogenic Organs and Their Interactive Organs with Immunostaining in the Fruit Fly Drosophila melanogaster. Journal of Visualized Experiments 122: e55519. DOI:10.3791/55519

[46 / O#38] Ameku T, Yoshinari Y, Fukuda R, Niwa R¶ (2017) Ovarian ecdysteroid biosynthesis and female germline stem cells. Fly 11: 185-193. DOI:10.1080/19336934.2017.1291472

2016

[45 / RE#8] Niwa YS, Niwa R¶ (2016) Ouija board: A transcription factor evolved for only one target in steroid hormone biosynthesis in the fruit fly Drosophila melanogaster. Transcription 7: 196-202. DOI:10.1080/21541264.2016.1210370

[44 / O#37] Ameku T, Niwa R¶ (2016) Mating-Induced Increase in Germline Stem Cells via the Neuroendocrine System in Female Drosophila. PLoS Genetics 12: e1006123. DOI:10.1371/journal.pgen.1006123

[43 / RE#7] Niwa YS¶, Niwa R¶ (2016) Transcriptional regulation of insect steroid hormone biosynthesis and its role in controlling timing of molting and metamorphosis. Development, Growth, and Differentiation 58: 94-105. DOI:10.1111/dgd.12248

2015

[42 / O#36] Komura-Kawa K, Hirota K, Shimada-Niwa Y, Yamauchi R, Shimell M, Shinoda T, Fukamizu A, O’Connor MB, Niwa R¶ (2015) The Drosophila Zinc Finger Transcription Factor Ouija Board Controls Ecdysteroid Biosynthesis through Specific Regulation of spookier. PLoS Genetics 11:e1005712. DOI:10.1371/journal.pgen.100571210

[41 / RE#6] Uryu O*, Ameku T*, Niwa R¶ (2015) Recent progress in understanding the role of ecdysteroids in adult insects: Germline development and circadian clock in the fruit fly Drosophila melanogaster. Zoological Letters 1:32. DOI:10.1186/s40851-015-0031-2

[40 / O#35] Fujikawa Y¶ Morisaki F, Ogura A, Morohashi K, Enya S, Niwa R, Goto S, Kojima H, Okabe T, Nagano T, Inoue H (2015) A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors. Chemical Communications 51: 11459-11462. DOI:10.1039/c5cc02067k.

[39 / O#34] Enya S, Daimon T, Igarashi F, Kataoka H, Uchibori M, Sezutsu H, Shinoda T, Niwa R¶ (2015) The silkworm glutathione S-transferase gene noppera-bo is required for ecdysteroid biosynthesis and larval development. Insect Biochemistry and Molecular Biology 61:1-7. DOI:10.1016/j.ibmb.2015.04.001

[38 / O#33] Ohhara Y, Shimada-Niwa Y, Niwa R, Kayashima Y, Hayashi Y, Akagi K, Ueda H, Yamakawa-Kobayashi K, Kobayashi S¶ (2015) Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis. Proceedings of National Academy of Science of the United States of America (PNAS) 112: 1452-1457. DOI:10.1073/pnas.1414966112

2014

[37 / O#32] Shimada-Niwa Y¶, Niwa R¶ (2014) Serotonergic neurons respond to nutrients and regulate the timing of steroid hormone biosynthesis in Drosophila. Nature Communications 5: 5778 DOI:10.1038/ncomms6778

[36 / O#31] Enya S, Ameku T, Igarashi F, Iga M, Kataoka H, Shinoda T, Niwa R¶ (2014) A Halloween gene noppera-bo encodes a glutathione S-transferase essential for ecdysteroid biosynthesis via regulating the behaviour of cholesterol in Drosophila. Scientific Reports 4:6586. DOI:10.1038/srep06586

[35 / RE#5] Niwa R¶, Niwa YS (2014) Enzymes for ecdysteroid biosynthesis: their biological functions in insects and beyond. Bioscience, Biotechnology, and Biochemistry 78: 1283-1292. DOI:10.1080/09168451.2014.942250

[34 / O#30] Danielsen ET, Moeller ME, Dorry E, Komura-Kawa T, Fujimoto Y, Troelsen JT, Herder R, O'Connor MB, Niwa R, Rewitz KF¶ (2014) Transcriptional control of steroid biosynthesis genes in the Drosophila prothoracic gland by ventral veins lacking and knirps. PLoS Genetics 10: e1004343. DOI:10.1371/journal.pgen.1004343

[33 / RE#4] Niwa YS¶, Niwa R¶ (2014) Neural control of steroid hormone biosynthesis during development in the fruit fly Drosophila melanogaster. Genes and Genetic Systems 2014;89: 27-34. DOI:10.1266/ggs.89.27

2013

[32 / O#29] Suetsugu Y, Futahashi R, Kanamori H, Kadono-Okuda K, Sasanuma SI, Narukawa J, Ajimura M, Jouraku A, Namiki N, Shimomura M, Sezutsu H, Osanai-Futahashi M, Suzuki MG, Daimon T, Shinoda T, Taniai K, Asaoka K, Niwa R, Kawaoka S, Katsuma S, Tamura T, Noda H, Kasahara M, Sugano S, Suzuki Y, Fujiwara H, Kataoka H, Arunkumar KP, Tomar A, Nagaraju J, Goldsmith MR, Feng Q, Xia Q, Yamamoto K, Shimada T, Mita K¶ (2013) Large Scale Full-Length cDNA Sequencing Reveals a Unique Genomic Landscape in a Lepidopteran Model Insect, Bombyx mori. G3 3: 1481-92. DOI:10.1534/g3.113.006239

2012

[31 / O#28] Lang M, Murat S, Clark AG, Gouppil G, Blais C, Matzkin LM, Guittard E, Yoshiyama-Yanagawa T, Kataoka H, Niwa R, Lafont R, Dauphin-Villemant C, Orgogozo V¶ (2012) Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species. Science 337: 1658-1661. DOI:10.1126/science.1224829

[30 / O#27] Sugiyama T¶, Sugioka-Sugiyama R, Hada K, Niwa R. (2012) Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast. PLoS One 2012;7: e42962. DOI:10.1371/journal.pone.0042962

[29 / O#26] Kamimura M, Saito H, Niwa R, Niimi T, Toyoda K, Ueno C, Kanamori Y, Shimura S, Kiuchi M (2012) Fungal ecdysteroid-22-oxidase: a new tool for manipulating ecdysteroid signaling and insect development. Journal of Biological Chemistry 287: 16488-16498. DOI:10.1074/jbc.M112.341180

[28 / O#25] Daimon T, Kozaki T, Niwa R, Kobayashi I, Furuta K, Namiki T, Uchino K, Banno Y, Katsuma S, Tamura T, Mita K, Sezutsu H, Nakayama M, Itoyama K, Shimada T, Shinoda T¶ (2012) Precocious Metamorphosis in the Juvenile Hormone-Deficient Mutant of the Silkworm, Bombyx mori. PLoS Genetics 8: e1002486. DOI:10.1371/journal.pgen.1002486

2011

[27 / O#24] Niwa R¶, Enya S (2011) A mitochondrial carrier gene, CG32103, is highly expressed in the corpora allata in the fruit fly Drosophila melanogaster (Diptera: Drosophilidae). Applied Entomology and Zoology 46: 573-580. DOI:10.1007/s13355-011-0079-1

[26 / O#23] Niwa R¶, Sakudoh T, Matsuya T, Namiki T, Kasai S, Tomita T, Kataoka H (2011) Expressions of the cytochrome P450 monooxygenase gene Cyp4g1 and its homolog in the prothoracic glands of the fruit fly Drosophila melanogaster (Diptera: Drosophilidae) and the silkworm Bombyx mori (Lepidoptera: Bombycidae). Applied Entomology and Zoology 46: 533-543. DOI:10.1007/s13355-011-0074-6

[25 / O#22] Yoshiyama-Yanagawa T*, Enya S*, Shimada-Niwa Y, Yaguchi S, Haramoto Y, Matsuya T, Shiomi K, Sasakura Y, Takahashi T, Asashima M, Kataoka H¶, Niwa R¶ (2011) The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol metabolizing enzyme. Journal of Biological Chemistry 286: 25756-25762. DOI:10.1074/jbc.M111.244384

[24 / O#21] Shimada Y, Burn KM, Niwa R, Cooley L¶ (2011) Reversible response of protein localization and microtubule organization to nutrient stress during Drosophila early oogenesis. Developmental Biology 355: 250-262. DOI:10.1016/j.ydbio.2011.04.022

[23 / RE#3] Niwa R¶, Niwa YS (2011) The Fruit Fly Drosophila melanogaster as a Model System to Study Cholesterol Metabolism and Homeostasis. Cholesterol 2011: Article ID 176802. DOI:10.1155/2011/176802

2010

[22 / O#20] Niwa R¶, Hada K (2010) Identification of a spatio-temporal enhancer element for the Alzheimer's amyloid precursor protein-like-1 gene in the nematode Caenorhabditis elegans. Bioscience, Biotechnology and Biochemistry 74: 2497-2950. DOI:10.1271/bbb.100450

[21 / O#19] Hada K, Asahina M, Hasegawa H, Kanaho Y, Slack FJ, Niwa R¶ (2010) The nuclear receptor gene nhr-25 plays multiple roles in the C. elegans heterochronic gene network to control the larva-to-adult transition. Developmental Biology 344: 1100-1109. DOI:10.1016/j.ydbio.2010.05.508

[20 / O#18] Niwa R¶, Namiki T, Ito K, Shimada-Niwa Y, Kiuchi M, Kawaoka S, Kayukawa T, Banno Y, Fujimoto Y, Shigenobu S, Kobayashi S, Shimada T, Katsuma S, Shinoda T¶. (2010). Non-molting glossy/shroud encodes a short-chain dehydrogenase/reductase that functions in the "Black Box" of the ecdysteroid biosynthesis pathway. Development 137: 1991-1999. DOI:10.1242/dev.045641

2009

[19 / O#17] Niwa R¶, Hada K, Moliyama K, Ohniwa RL, Tan Y-M, Olsson Carter K, Chi W, Reinke V, Slack FJ¶. C. elegans sym-1 is a downstream target of the Hunchback-like-1 developmental timing transcription factor. Cell Cycle 8: 4147-4154. DOI:10.4161/cc.8.24.10292

[18 / O#16] Namiki T*, Niwa R*, Higuchi A, Yoshiyama T, Mita K, Kataoka H¶ (2009) A basic-HLH transcription factor HLH54F is highly expressed in the prothoracic gland in the silkworm Bombyx mori and the fruit fly Drosophila melanogaster. Bioscience, Biotechnology, and Biochemistry 73: 762-765. DOI:10.1271/bbb.80737

2008

[17 / O#15] Niwa R, Niimi T, Honda N, Yoshiyama M, Itoyama K, Kataoka H, Shinoda T¶ (2008) Juvenile hormone acid O-methyltransferase in Drosophila melanogaster. Insect Biochemistry and Molecular Biology 38: 714-720. DOI:10.1016/j.ibmb.2008.04.003

[16 / O#14] Niwa R, F Zhou, C Li, FJ Slack¶ (2008) The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Developmental Biology 315: 418-425. DOI:10.1016/j.ydbio.2007.12.044

2007

[15 / O#13] Yamanaka N, Honda N, Osato N, Niwa R, Mizoguchi A, Kataoka H¶ (2007) Differential regulation of ecdysteroidogenic P450 gene expression in the silkworm, Bombyx mori. Bioscience, Biotechnology, and Biochemistry 71: 2808-2814. DOI:10.1271/bbb.70420

[14 / RE#2] Niwa R, Slack FJ¶ (2007) The evolution of animal microRNA function. Current Opinion in Genetics & Development 17: 145-150. DOI:10.1016/j.gde.2007.02.004

[13 / RE#1] Niwa R, Slack FJ¶ (2007) Ins and outs of RNA interference analysis. Cell (special issue) 34-36

2006

[12 / O#12] Yoshiyama T, Namiki T, Mita K, Kataoka H¶, Niwa R¶ (2006) Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth. Development 133: 2565-2574. DOI:10.1242/dev.02428

2005

[11 / O#11] Namiki T*, Niwa R*, Sakudoh T, Shirai K, Takeuchi H, Kataoka H¶ (2005) Cytochrome P450 CYP307A1/Spook: a regulator for ecdysone synthesis in insects. Biochemical and Biophysical Research Communications 337:367-374. DOI:10.1016/j.bbrc.2005.09.043

[10 / O#10] Niwa R¶, Sakudoh T, Namiki T, Saida K, Fujimoto Y, Kataoka H¶ (2005) The ecdysteroidogenic P450 Cyp302a1/disembodied from the silkworm, Bombyx mori, is transcriptionally regulated by prothoracicotropic hormone. Insect Molecular Biology 14: 563-571. DOI:10.1111/j.1365-2583.2005.00587.x

[9 / O#9] Yamanaka N, Hua YJ, Mizoguchi A, Watanabe K, Niwa R, Tanaka Y, Kataoka H¶ (2005) Identification of a novel prothoracicostatic hormone and its receptor in the silkworm Bombyx mori. Journal of Biological Chemistry 280: 14684-14690. DOI:10.1074/jbc.M500308200

2004

[8 / O#8] Niwa R¶, T Matsuda, T Yoshiyama, T Namiki, K Mita, Y Fujimoto, Kataoka H¶ (2004) CYP306A1, a cytochrome P450 enzyme, is essential for ecdysteroid biosynthesis in the prothoracic glands of Bombyx and Drosophila. Journal of Biological Chemistry 279: 35942-35949. DOI:10.1074/jbc.M404514200

[7 / O#7] Nagata-Ohashi K, Ohta Y, Goto K, Chiba S, Mori R, Nishita M, Ohashi K, Kousaka K, Iwamatsu A, Niwa R, Uemura T, Mizuno K¶ (2004) A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. Journal of Cell Biology 165: 465-471. DOI:10.1083/jcb.200401136

[6 / O#6] Nishita M, Wang Y, Tomizawa C, Suzuki A, Niwa R, Uemura T, Mizuno K¶ (2004) Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. Journal of Biological Chemistry 279: 7193-7198. DOI:10.1074/jbc.M312591200

2003

[5 / O#5] Ohta Y, Kousaka K, Nagata‐Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K¶ (2003) Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. Genes to Cells 8: 811-824. DOI:10.1046/j.1365-2443.2003.00678.x

[4 / O#4] Kaji N, Ohashi K, Shuin M, Niwa R, Uemura T, Mizuno K¶ (2003) Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. Journal of Biological Chemistry 278: 33450-33455. DOI:10.1074/jbc.M305802200

[3 / O#3] Sugimura K, Yamamoto M, Niwa R, Satoh D, Goto S, Taniguchi M, Hayashi S, Uemura T¶ (2003) Distinct developmental modes and lesion-induced reactions of dendrites of two classes of Drosophila sensory neurons. Journal of Neuroscience 23: 3752-3760. DOI:10.1523/JNEUROSCI.23-09-03752.2003

[2 / O#2] Endo M, Ohashi K, Sasaki Y, Goshima Y, Niwa R, Uemura T, Mizuno K¶ (2003) Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. Journal of Neuroscience 23: 2527-2537. DOI:10.1523/JNEUROSCI.23-07-02527.2003

2002

[1 / O#1] Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T¶ (2002) Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell 108: 233-246. DOI:10.1016/S0092-8674(01)00638-9