Publications
2023
Yamada T, Yoshinari Y, Tobo M, Habara O, Nishimura T#
Nature Communications, 2023 Sep 1;14(1): 5328. doi: 10.1038/s41467-023-41103-1. プレス発表
Hoshino R, Sano H, Yoshinari Y, Nishimura T, Niwa R#
Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in mated Drosophila.
Science Advances, 2023 Feb 24;9(8): eadd5551. doi: 10.1126/sciadv.add5551. プレス発表（筑波大学）
Banzai K, and Nishimura T#
Isolation of a novel missense mutation in insulin receptor as a spontaneous revertant of ImpL2 mutants in Drosophila.
Development, 2023 Jan 1; 150(1): dev201248. doi: 10.1242/dev.201248. プレス発表
2022
Sano H#, Nakamura A, Yamane M, Niwa H, Nishimura T, Araki K, Takemoto K, Ishiguro KI, Aoki H, Kato Y, Kojima M
The polyol pathway is an evolutionarily conserved system for sensing glucose uptake.
PLoS Biology, 2022 Jun 10; 20(6): e3001678. doi: 10.1371/journal.pbio.3001678. プレス発表
Ciesielski HM*, Nishida H*, Takano T, Fukuhara A, Otani T, Ikegawa Y, Okada M, Nishimura T, Furuse M, Yoo SK#
Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes.
PLoS Biology, 2022 Apr 25; 20(4): e3001586. doi: 10.1371/journal.pbio.3001586.
Inaba K, Ebihara K, Senda M, Yoshino R, Sakuma C, Koiwai K, Takaya D, Watanabe C, Watanabe A, Kawashima Y, Fukuzawa K, Imamura R, Kojima H, Okabe T, Uemura N, Kasai S, Kanuka H, Nishimura T, Watanabe K, Inoue H, Fujikawa Y, Honma T, Hirokawa T, Senda T, Niwa R#
Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti.
BMC Biology, 2022 Feb 17; 20(1): 43. doi: 10.1186/s12915-022-01233-2. プレス発表（筑波大学）
Noguchi K, Yokozeki K, Tanaka Y, Suzuki Y, Nakajima K, Nishimura T, Goda N#
Sima, a Drosophila homolog of HIF-1alpha, in fat body tissue inhibits larval body growth by inducing Tribbles gene expression.
Genes Cells, 2022 Feb; 27(2): 145-151. doi: 10.1111/gtc.12913.
○日本後総説
吉成祐人、丹羽隆介、西村隆史
「腸からはじまる臓器連関と栄養環境の変化に対する適応戦略」
実験医学増刊 Vol.40 No.7「栄養・代謝物シグナルと食品機能」（羊土社HP）
2021
Sasaki A, Nishimura T, Takano T, Naito S, Yoo SK#
white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila.
Nature Metabolism, 2021 Apr; 3(4): 546-557. doi: 10.1038/s42255-021-00375-x. プレス発表（理研）
2020
Yamada T*, Hironaka KI*, Habara O, Morishita Y, Nishimura T#
A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila.
Nature Metabolism, 2020 Oct; 2(10): 1096-1112. doi: 10.1038/s42255-020-00293-4. プレス発表（理研）
Nishimura T#
Feedforward Regulation of Glucose Metabolism by Steroid Hormones Drives a Developmental Transition in Drosophila.
Current biology, 2020 Sep 21; 30(18): 3624-3632. e5. doi: 10.1016/j.cub.2020.06.043. プレス発表（理研）
Imura E, Shimada-Niwa Y#, Nishimura T, Hückesfeld S, Schlegel P, Ohhara Y, Kondo S, Tanimoto H, Cardona A, Pankratz MJ, Niwa R
The Corazonin-PTTH Neuronal Axis Controls Systemic Body Growth by Regulating Basal Ecdysteroid Biosynthesis in Drosophila melanogaster.
Current biology, 2020 Jun 8; 30(11): 2156-2165. e5. doi: 10.1016/j.cub.2020.03.050. プレス発表（筑波大学）
Matsushita R, Nishimura T#
Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis.
Communications Biology, 2020 Apr 7; 3(1): 170. doi: 10.1038/s42003-020-0889-1. プレス発表（理研）
2019
Hironaka KI#, Fujimoto K, Nishimura T#
Optimal Scaling of Critical Size for Metamorphosis in the Genus Drosophila.
iScience, 2019 Oct 25; 20: 348-358. doi: 10.1016/j.isci.2019.09.033. プレス発表（理研）
Silver JT*, Wirtz-Peitz F*, Simões S*, Pellikka M*, Yan D, Binari R, Nishimura T, Li Y, Harris TJC, Perrimon N, Tepass U#
Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly.
Journal of Cell Biology, 2019 Oct 7; 218(10): 3397-3414. doi: 10.1083/jcb.201807106.
Yamada T, Habara O, Yoshii Y, Matsushita R, Kubo H, Nojima Y, Nishimura T#
The role of glycogen in development and adult fitness in Drosophila.
Development, 2019 pr 15; 146(8): dev176149. doi: 10.1242/dev.176149.
2018
Yamada T, Habara O, Kubo H, Nishimura T#
Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila.
Development, 2018 Mar 14; 145(6): dev158865. doi: 10.1242/dev.158865. ニュース記事（理研）
Niwa R#, Nishimura T
Assembly of insect hormone enthusiasts at Nasu Highland, Japan: Report of the 3rd International Insect Hormone (21st Ecdysone) Workshop.
Genes to Cells, 2018 Jan; 23(1): 16-21. doi: 10.1111/gtc.12543. Review
2017
Yasugi T, Yamada T, Nishimura T#
Adaptation to dietary conditions by trehalose metabolism in Drosophila.
Scientific Reports, 2017 May 9; 7(1): 1619. doi: 10.1038/s41598-017-01754-9. ニュース記事（理研）
2016
Yoshida M*, Matsuda H*, Kubo H, Nishimura T#
Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis.
Scientific Reports, 2016 Jul 29; 6: 30582. doi: 10.1038/srep30582. ニュース記事（理研）
Yasugi T#, Nishimura T#
Temporal regulation of the generation of neuronal diversity in Drosophila.
Development Growth & Differentiation, 2016 Jan; 58(1): 73-87. doi: 10.1111/dgd.12245. Review
2015
Okamoto N, Nishimura T#
Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth.
Developmental Cell, 2015 Nov 9; 35(3): 295-310. doi: 10.1016/j.devcel.2015.10.003. プレス発表（理研） ニュース記事（理研）
Matsuda H*, Yamada T*, Yoshida M, Nishimura T#
Flies without trehalose.
Journal of Biological Chemistry. 2015 Jan 9; 290(2): 1244-55. doi: 10.1074/jbc.M114.619411. ニュース記事（理研）
2013
Okamoto N, Nakamori R, Murai T, Yamauchi Y, Masuda A, Nishimura T#
A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila.
Genes & Development, 2013 Jan 1; 27(1): 87-97. doi: 10.1101/gad.204479.112. プレス発表（理研） ニュース記事（理研）
2012
Okamoto N, Nishimori Y, Nishimura T#
Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression.
Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7): 2406-11. doi: 10.1073/pnas.1116050109 ニュース記事（理研）
2010
Itoh N, Nakayama M, Nishimura T, Fujisue S, Nishioka T, Watanabe T, Kaibuchi K#
Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis.
Cytoskeleton, 2010 May; 67(5): 297-308. doi: 10.1002/cm.20444.
2009
Wirtz-Peitz F*, Nishimura T*, Knoblich JA#
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.
Cell, 2008 Oct 3; 135(1): 161-73. doi: 10.1016/j.cell.2008.07.049.
2008
Nakayama M, Goto TM, Sugimoto M, Nishimura T, Shinagawa T, Ohno S, Amano M, Kaibuchi K#
Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.
Developmental Cell, 2008 Feb; 14(2): 205-15. doi: 10.1016/j.devcel.2007.11.021.
2007
Nishimura T, Kaibuchi K#
Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.
Developmental Cell, 2007 Jul;13(1):15-28. doi: 10.1016/j.devcel.2007.05.003.
Takefuji M, Mori K, Morita Y, Arimura N, Nishimura T, Nakayama M, Hoshino M, Iwamatsu A, Murohara T, Kaibuchi K, Amano M#
Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation.
Biochem Biophys Res Commun, 2007 Apr 13; 355(3): 788-94. doi: 10.1016/j.bbrc.2007.02.028.
2006
Nishimura T, Yamaguchi T, Tokunaga A, Hara A, Hamaguchi T, Kato K, Iwamatsu A, Okano H, Kaibuchi K#
Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.
Molecular Biology of the Cell, 2006 Mar; 17(3): 1273-85. doi: 10.1091/mbc.e05-07-0700.
2005
Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuchi K#
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Nature Cell Biology, 2005 Mar; 7(3): 270-7. doi: 10.1038/ncb1227.
2004
Nishimura T*, Kato K*, Yamaguchi T, Fukata Y, Ohno S, Kaibuchi K#
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity.
Nature Cell Biology, 2004 Apr; 6(4): 328-34. doi: 10.1038/ncb1118.
2003
Nishimura T, Fukata Y, Kato K, Yamaguchi T, Matsuura Y, Kamiguchi H, Kaibuchi K#
CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.
Nature Cell Biology, 2003 Sep; 5(9): 819-26. doi: 10.1038/ncb1039.
2002
Fukata Y, Itoh TJ, Kimura T, Ménager C, Nishimura T, Shiromizu T, Watanabe H, Inagaki N, Iwamatsu A, Hotani H, Kaibuchi K#
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.
Nature Cell Biology, 2002 Aug; 4(8): 583-91. doi: 10.1038/ncb825.
2001
Inagaki N, Chihara K, Arimura N, Ménager C, Kawano Y, Matsuo N, Nishimura T, Amano M, Kaibuchi K#
CRMP-2 induces axons in cultured hippocampal neurons.
Nature Neuroscience, 2001 Aug; 4(8): 781-2. doi: 10.1038/90476.