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https://pmc.ncbi.nlm.nih.gov/articles/PMC6926416/
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https://www.jacc.org/doi/10.1016/j.jchf.2024.03.003
https://pmc.ncbi.nlm.nih.gov/articles/PMC8946995/
Global cachexia, including cancer induced and cardiac cachexia, is a generalized process that involves edema-free muscle loss but may also affect the adipose tissue and other energetic reserves. It may also involve the bones. According to the 2008 criteria, cardiac cachexia is characterized by a loss of 5% of body weight during the last 12 months, without edema, a body mass index of <20 kg/m2 and the presence of at least three of the following clinical findings: decreased muscular strength, anorexia, low body mass free of fat, fatigue, elevated reactive C protein and IL-6, hypoalbuminemia < 3.2 g/dL, hemoglobin < 12 g/dL and anemia. Cachexia is a nutritional syndrome because nutrients such as protein and calories are required to reverse it, and anorectic components participate in it.