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Racial, ethnic and socioeconomic disparities exist in the quality of primary care for patients with chronic kidney disease (CKD) and CKD risk factors. Low-income and racial and ethnic minority patients are less likely to receive recommended care related to CKD risk factors and are less likely to reduce CKD risk through recommended treatment goals (blood pressure, diabetes, cholesterol control). Racial and ethnic minorities are also more likely to progress from CKD to end-stage renal disease (ESRD)—also known as end-stage kidney disease (ESKD)—and are less likely to have been under the care of a nephrologist before starting dialysis. These disparities are related to patient, clinician, clinical and system factors. • Patient factors include genetic predisposition (e.g., APOL1 risk variants), barriers to accessing care, low health literacy, cultural and attitudinal beliefs, such as mistrust of health care providers and language barriers. • Clinician factors include limited knowledge of CKD, discomfort with its clinical complexity, and communication challenges. • Clinical factors include conflicting guidance about screening for CKD and the complexity of treating patients with multiple comorbid conditions. • System factors include limited access to care and lack of clinical decision support tools. Primary care practice teams can help reduce disparities in care for CKD through early identification, treatment, monitoring progression, collaborating with nephrologists and other specialists, building care teams and engaging patients. This educational guide is intended to foster the development of primary care practice teams in order to enhance care for vulnerable patients who are at risk of CKD or who have CKD and are at risk of progression of disease or complications. This guide addresses three aspects of care: identification of CKD; treatment and monitoring progression; and delivering patient-centered care. It is meant to inform readers about disparities in the care of patients with CKD, present potential actions that may improve care and suggest other available resources that may be used by primary care practice teams in caring for vulnerable patients. About Chronic Kidney Disease CKD is progressive loss of renal function, beginning with