Ebook: https://www.mrs-mexico.org.mx/imrc2023/abstracts-read.php?r=00253&id=12

This work used the electrospinning technique to obtain polymeric fiber mats of polyvinyl alcohol (PVA= 89,000-98,000 Mw) with encapsulated collagen, aloe vera, and Manuka honey. We varied the electrospinning parameters such as voltage, distance, concentration, and flow parameters to obtain the ideal fiber diameter for the gradual release of the active ingredients. Once the ideal morphology was established, the compounds were individually integrated into the PVA fibers, using different concentrations to determine their effects on the fiber. The fiber morphology was analyzed by Scanning electron microscopy (SEM). Through Fourier transform infrared spectroscopy (FTIR), we confirmed the presence of the active ingredients in the fibers, and assessed any potential chemical interaction between PVA and the components. To finalize the films characterization, X-ray diffraction was utilized to observe if the structure of the compounds had changed after the electrospinning process. UV-VIS method was employed to asses the release profile of the active ingredients. To verify the antimicrobial properties, the film was exposed to E. coli and S. aureus bacteria to determine the bacterial activity on the surface of the patch.

Ebook: https://www.mrs-mexico.org.mx/imrc2023/abstracts-read.php?r=00579&id=21 

Drug delivery with nanomaterials has shown promising results for targeted and controlled release of drugs, including methotrexate (MTX), a widely used chemotherapeutic agent for breast cancer treatment. However, the clinical application of MTX is limited due to its poor pharmacokinetic properties and potential toxic effects on healthy tissues. Thus, the development of efficient drug delivery systems (DDS) for MTX has become a crucial step in the improvement of its therapeutic efficacy and safety profile. In this regard, a systematic review of the current literature was conducted to identify various nanomaterials used for drug delivery, including magnetic nanoparticles, solid lipid nanoparticles, dendrimers, nanogels, and lignin-based nanoparticles. The systematic review conducted in this study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The literature search was conducted using specific inclusion and exclusion criteria. The inclusion criteria were as follows: the record contained recent information, starting the year 2017; the record indicated the form of encapsulation of methotrexate (MTX); the record was related to breast cancer pathology. On the other hand, the exclusion criteria were as follows: the record did not specify the encapsulation efficiency; the record did not show results related to the topic of interest; the record did not indicate the type of cells used in the experimentation, and there was no access to the full article. Our study highlights the key features and performance of these nanocarriers in terms of encapsulation efficiency, loading capacity, particle size, zeta potential, and cell viability. Our findings indicate that PLGA-coated magnetic nanoparticles exhibit the highest percentage of encapsulation (95%), but a moderate release of about 20% at 24 h. While the biotin-PEG-conjugated nanogels present the highest release (90%) although their encapsulation percentage is 40%. Despite the diversity of nanomaterials, all studies aimed to enhance the efficacy and safety of MTX delivery in breast cancer. These findings suggest that nanomaterials hold great potential as DDS for MTX and highlight the importance of continued research in this field to overcome the limitations of MTX therapy and improve the quality of life of breast cancer patients.

Ebook: https://www.mrs-mexico.org.mx/imrc2023/abstracts-read.php?r=01628&id=27

The interaction of gold nanoparticles (AuNPs) with cysteine and its derivatives is the basis of a number of potential applications in various fields such as medicine, catalysis, and nanoelectronics. Cysteine is present in a zwitterionic form between a pH range of 1.91 to 8.16 and it is commonly understood that the thiol group of cysteine is highly attracted to soft metals. A detailed first-principles calculation was performed to investigate the electronic properties of the interaction between cysteine and gold nanoparticles. In this study, the CASTEP package of Materials Studio were employed to perform geometry optimization and energy calculations. The interaction between the surface of gold nanoparticles and cysteine at the atomic level was investigated. Calculated results showed the presence of covalent bonds between the gold nanoparticle and cysteine, with interface bond energy ranging -387.36 to -387.675 Kcal/mol. The significance of this research lies in the fact that it sheds light on the fundamental properties of the gold-cysteine system, which can be used to develop novel functional materials with enhanced properties. The results also highlight the importance of studying the molecular interaction between materials at the atomic level to gain a deeper understanding of their behavior and to optimize their performance in practical applications. These findings provide valuable insight into the nature and strength of the interaction between the two materials and contribute to a better understanding of their potential applications.