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We present the outcomes of a two-stage research project focused on the development and characterization of nanostructured delivery systems for bioactive compounds extracted from pecan (Carya illinoinensis), a high-yield nut crop in the state of Chihuahua. Using an optimized solvent-evaporation micro/emulsion protocol, our team produced PCL/PVA-based micro/nano carriers encapsulating tocopherols, tocotrienols and phenolic extracts. Formulations were fully characterized (DLS, FTIR, SEM, TGA) and release profiles were obtained under simulated physiological conditions. Kinetic analysis indicates sustained release compatible with adjuvant strategies for chemotherapeutic regimens; mechanistic fits suggest combined diffusion-erosion transport dominating the release behavior.
The project combined laboratory research with a strong training and dissemination component: more than a dozen presentations at national and international conferences, multiple student theses and professional internships, and outreach events including a dedicated workshop during the 31st Engineering Week. Results were disseminated through a technical article published in Nano-Structures & Nano-Objects (2025) and an audiovisual series on the group’s YouTube channel. These outputs demonstrate the project’s dual contribution to scientific knowledge (novel formulation protocols and comparative release data) and regional capacity building (trained personnel, shared protocols and public engagement).
Peer-reviewed article: Nanostructured delivery systems for antioxidants: Comparative release of purified ellagic acid and extracted polyphenols, Nano-Structures & Nano-Objects (2025).
Workshop: “Nanomedicine: microencapsulation of anti-cancer bioactives” (31st Engineering Week).
Outreach: 7 short videos on the group YouTube channel and multiple conference presentations (IMRC, IUPESM, national meetings).