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Develop and characterize nanoscale carriers for the synergistic delivery of anticancer drugs and phenolic-rich extracts, with a particular focus on leukemia, using ultrasound-assisted encapsulation, and evaluate their efficacy and response biomarkers in cell lines.
Design and optimize electrospun fibers incorporating bioactive compounds or drugs to achieve controlled and sustained release for dermal applications, including patches and diabetic foot wound management. Evaluate these systems in cell-based assays and an animal model.
Design, synthesize, and functionalize magnetic nanoparticles (Fe₃O₄ and other ferrites) for advanced biomedical applications, including targeted delivery of drugs and antioxidants, magnetic hyperthermia, and imaging as part of combined therapeutic strategies, and evaluate their physicochemical and biological performance in in vitro systems.
Develop green synthesis methods for metallic nanoparticles using phenolic compounds (natural extracts or purified compounds) as reducing and stabilizing agents, and characterize their photonic response (surface plasmon resonance, SPR), colloidal stability, and photothermal potential.
Formulate polymer matrices reinforced with nanomaterials and loaded with bioactive agents for applications in patches and wound healing, and evaluate their degradation under simulated physiological conditions, mechanical properties, and biocompatibility.
Explore metal–organic frameworks (MOFs) and coordination/organometallic complexes for biomedical applications, including drug encapsulation, the development of antimicrobial agents, and sensing.
Develop computational models based on artificial intelligence, molecular docking, and in silico simulations to predict protein–drug, protein–natural compound, and protein–nanomaterial interactions, with the aim of identifying therapeutic targets, optimizing combinations, and prioritizing formulations for experimental validation. In collaboration with BiomeAI.
Develop, characterize, and evaluate cyclodextrin-based supramolecular platforms for advanced biomedical applications, including improved drug solubility and stability, controlled and targeted release, cell membrane modulation, combined therapeutic systems, tissue engineering, diagnostics, and biosensors, integrating physicochemical, biological, and in silico studies.