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Lyme disease is a serious bacterial infection caused by a tick bite and affects humans and animals.
This page contains citations and complete abstracts for medical and scientific articles from the National Institutes of Health (NIH), National Library of Medicine (NLM) MEDLINE database about pregnancy complications and Lyme disease. Citations are sorted by date within categories with particularly significant portions highlighted in bold lettering.
Click on link shown after "TITLE:" to see complete citation/abstract.
Primary references for pregnancy complications and Lyme disease
Other references - animal studies, single patient reports, etc.
References, citations only (i.e., no abstract available.)
For more information about Lyme disease
Note: Most of the abstracts and annotations below were gleaned from citations found by the following MEDLINE "search" link:
MEDLINE - Fetal, pregnancy, birth-defect, etc. AND Lyme disease - 266 on 23 Jun 00
TITLE:
Lyme borreliosis as a cause of facial palsy during pregnancy.
AUTHORS:
Grandsaerd MG; Meulenbroeks AA
AUTHOR AFFILIATION:
Department of Otorhinolaryngology, Rijnstate hospital Wagnerlaan 55 6815 AD, Arnhem, The Netherlands
ABSTRACT:
The medical history of a pregnant woman in whom the initial pattern of complaints suggested hyperemesis gravidarum is described. After about 18 days the patient developed left facial palsy. Repeated tests eventually confirmed the diagnosis of neuroborreliosis. The problems concerning diagnostics, therapy and the possible complications of Lyme borreliosis during gestation are described.
NLM PUBMED CIT. ID: 10817889 NLM CIT. ID: No Cit. ID Assigned
SOURCE:
Eur J Obstet Gynecol Reprod Biol 2000 Jul 1;91(1):99-101
TITLE:
AUTHORS:
Williams CL; Strobino B; Weinstein A; Spierling P; Medici F
AUTHOR AFFILIATION:
Child Health Center, American Health Foundation, Valhalla, New York 10595, USA.
ABSTRACT:
This report describes a cohort study of over 5000 infants and their mothers who participated in a cord blood serosurvey designed to examine the relationship between maternal exposure to Lyme disease and adverse pregnancy outcome. Based on serology and reported clinical history, mothers of infants in an endemic hospital cohort are 5 to 20 times more likely to have been exposed to B. burgdorferi as compared with mothers of infants in a control hospital cohort. The incidence of total congenital malformations was not significantly different in the endemic cohort compared with the control cohort, but the rate of cardiac malformations was significantly higher in the endemic cohort [odds ratio (OR) 2.40; 95% confidence interval (CI) 1.25, 4.59] and the frequencies of certain minor malformations (haemangiomas, polydactyly, and hydrocele), were significantly increased in the control group. Demographic variations could only account for differences in the frequency of polydactyly. Within the endemic cohort, there were no differences in the rate of major or minor malformations or mean birthweight by category of possible maternal exposure to Lyme disease or cord blood serology. The disparity between observations at the population and individual levels requires further investigation. The absence of association at the individual level in the endemic area could be because of the small number of women who were actually exposed either in terms of serology or clinical history. The reason for the findings at the population level is not known but could be because of artifact or population differences.
NLM PUBMED CIT. ID: 7479280 NLM CIT. ID: 96061203
SOURCE:
Paediatr Perinat Epidemiol 1995 Jul;9(3):320-30
TITLE:
[Manifestation of Lyme arthritis in the puerperal period]
VERNACULAR TITLE:
Manifestation einer Lyme-Arthritis im Wochenbett.
AUTHORS:
Bussen S; Steck T
AUTHOR AFFILIATION:
Universitatsfrauenklinik Wurzburg.
ABSTRACT:
Lyme disease, a tick-transmitted spirochetal illness caused by Borrelia burgdorferi, usually begins with a characteristic erythema chronicum migrans accompanied by flu-like symptoms. This phase may later be followed by meningitis, neuritis, carditis or arthritis.Congenital abnormalities due to maternal infection during pregnancy have been described. We report on a case of a 36-year old V gravida III para. After a normal pregnancy and a Cesarean section the patient developed postpartal an acute Lyme arthritis.
NLM PUBMED CIT. ID: 7975802 NLM CIT. ID: 95066274
SOURCE:
Z Geburtshilfe Perinatol 1994 Aug;198(4):150-2
TITLE:
Congenital infections and the nervous system.
AUTHORS:
Bale JF Jr; Murph JR
AUTHOR AFFILIATION:
Department of Pediatrics, University of Iowa College of Medicine, Iowa City.
ABSTRACT:
Despite vaccines, new antimicrobials, and improved hygienic practices, congenital infections remain an important cause of death and long-term neurologic morbidity among infants world-wide. Important agents include Toxoplasma gondii, cytomegalovirus, Treponema pallidum, herpes simplex virus types 1 and 2, and rubella virus. In addition, several other agents, such as the varicella zoster virus, human parvovirus B19, and Borrelia burgdorferi, can potentially infect the fetus and cause adverse fetal outcomes.This article provides an overview of these infectious disorders and outlines current strategies for acute treatment and long-term management.
NLM PUBMED CIT. ID: 1321971 NLM CIT. ID: 92342460
SOURCE:
Pediatr Clin North Am 1992 Aug;39(4):669-90
TITLE:
[Borrelia infections from a dermatological viewpoint]
VERNACULAR TITLE:
Borrelieninfektion aus dermatologischer Sicht.
AUTHORS:
Vocks E; Engst R; Borelli S
AUTHOR AFFILIATION:
Dermatologische Klinik und Poliklinik Technischen Universitat Munchen. ABSTRACT:
Erythema migrans (EM), Borrelia lymphocytoma (BL) and acrodermatitis chronica atrophicans (ACA) are the established dermatological manifestations of borrelia infection, a complex multiorganic disease. Analogous to syphilis Borrelia infection can be classified by three stages, at which stage I (localized infection) and II (disseminated infection) are manifestations of early infection and stage III (persistent infection) a symptom of late infection. At all stages skin manifestations can be present, the above mentioned as stage-marker as well as other non-specific polymorphous skin lesions which sometimes appear at stage II. Because of its frequent (60-80%) occurrence in all borrelia infections EM has a pathognomonic importance for borrelia infection. In diagnosis serology is currently the only practical laboratory aid. False negative and false positive results must be considered. Treatment of choice is ceftriaxone, penicillin G (or amoxycillin) or tetracycline. Prophylactic antibiotic therapy for tick bites is not recommended. Congenital borrelia infections seem to be unusual, but it is likely that they can occur and cause different adverse fetal outcome or abortion.
NLM PUBMED CIT. ID: 1922122 NLM CIT. ID: 92017931
SOURCE:
Monatsschr Kinderheilkd 1991 Jul;139(7):425-8
TITLE:
Lyme disease during pregnancy.
AUTHORS:
Schutzer SE; Janniger CK; Schwartz RA
AUTHOR AFFILIATION:
Department of Allergy and Immunology, New Jersey Medical School, Newark 07103-2714.
ABSTRACT:
Lyme disease, caused by infection with Borrelia burgdorferi, can affect those exposed to a vector tick. Pregnant women are no exception, and such infection places the fetus at risk. It is particularly important to recognize the disease early so that effective therapy may be instituted. Although the present patient had a favorable outcome, not all do. Clinical diagnosis is especially important since conventional laboratory tests may be inadequate or require lengthy periods of time before a positive result occurs. The dermatologic sign of Lyme disease, erythema migrans, although occurring in only 50 percent of cases, is likely to be the most important diagnostic sign.
NLM PUBMED CIT. ID: 2070648 NLM CIT. ID: 91300895
SOURCE:
Cutis 1991 Apr;47(4):267-8
TITLE:
Gestational Lyme borreliosis. Implications for the fetus.
AUTHORS:
MacDonald AB
AUTHOR AFFILIATION:
Southampton Hospital, New York.
ABSTRACT:
Great diversity of clinical expression of signs and symptoms of gestational Lyme borreliosis parallels the diversity of prenatal syphilis. It is documented that transplacental transmission of the spirochete from mother to fetus is possible. Further research is necessary to investigate possible teratogenic effects that might occur if the spirochete reaches the fetus during the period of organogenesis. Autopsy and clinical studies have associated gestational Lyme borreliosis with various medical problems including fetal death, hydrocephalus, cardiovascular anomalies, neonatal respiratory distress, hyperbilirubinemia, intrauterine growth retardation, cortical blindness, sudden infant death syndrome, and maternal toxemia of pregnancy. Whether any or all of these associations are coincidentally or causally related remains to be clarified by further investigation. It is my expectation that the spectrum of gestational Lyme borreliosis will expand into many of the clinical domains of prenatal syphilis.
NLM PUBMED CIT. ID: 2685924 NLM CIT. ID: 90069113
SOURCE:
Rheum Dis Clin North Am 1989 Nov;15(4):657-77
TITLE:
[Clinical aspects of Borrelia burgdorferi infections]
VERNACULAR TITLE:
Klinische Aspekte der Borrelia-burgdorferi-Infektionen.
AUTHORS:
Neubert U
AUTHOR AFFILIATION:
Dermatologische Klinik der Ludwig-Maximilians-Universitat Munchen.
ABSTRACT:
Skin lesions due to Borrelia burgdorferi-like erythema migrans, lymphadenosis cutis benigna, and acrodermatitis chronica atrophicans - are hall-marks of a systemic infection, which tends to a chronically relapsing course. Even if the skin lesions are missing, or disappear spontaneously, the infection may persist and affect other organs. This presumption is supported by the outcome of a long-term follow-up study on seropositive forest workers. In association with meningopolyneuritis (Garin-Bujadoux-Bannwarth disease) and acrodermatitis chronica atrophicans - myositis and fasciitis have been recently reported as further possible manifestations of Borrelia burgdorferi infection. Borrelial infection during pregnancy should promptly be treated with antibiotics in high dosages, in order to prevent maternal-fetal transmission of borrelial organisms resulting in stillbirth or congenital defects of the newborn.
NLM PUBMED CIT. ID: 2678790 NLM CIT. ID: 90021654
SOURCE:
Z Hautkr 1989 Aug 15;64(8):649-52, 655-6
TITLE:
Infants born to mothers with antibodies against Borrelia burgdorferi at delivery.
AUTHORS:
Nadal D; Hunziker UA; Bucher HU; Hitzig WH; Duc G
AUTHOR AFFILIATION:
Abteilungen fur Infektionskrankheiten und Immunologie der Universitat, Zurich, Switzerland.
ABSTRACT:
A serological survey over a 1-year period of 1416 mothers at delivery and their 1434 offspring for the presence of anti-Borrelia burgdorferi antibodies revealed a prevalence of 0.85%. Clinically active Lyme disease during pregnancy was found in 1 of these 12 women with elevated titres and the child was born with a ventricular septal defect. Of six affected children, two had hyperbilirubinaemia, one muscular hypotonia, one was underweight for gestational age, one was macrocephalic, and one had supraventricular extrasystoles. Anomalous findings could not be attributed to B. burgdorferi due to a lack of serological evidence of intrauterine infection. Our data do not imply the need for serological screening in pregnancy, however, the importance of recognition and treatment of Lyme disease in pregnancy is emphasized.
NLM PUBMED CIT. ID: 2920747 NLM CIT. ID: 89153177
SOURCE:
Eur J Pediatr 1989 Feb;148(5):426-7
TITLE:
Lyme Borrelia positive serology associated with spontaneous abortion in an endemic Italian area.
AUTHORS:
Carlomagno G; Luksa V; Candussi G; Rizzi GM; Trevisan G
AUTHOR AFFILIATION:
Dept. of Obstetrics and Gynecology, University of Trieste School of Medicine.
ABSTRACT:
Lyme borreliosis acquired during pregnancy may be associated with stillbirth and fetal malformations. This paper reports preliminary results of a study intended to evaluate the frequency of Borrelia burgdorferi infection associated with spontaneous abortion in an endemic Italian area.
NLM PUBMED CIT. ID: 3252658 NLM CIT. ID: 89300130
SOURCE:
Acta Eur Fertil 1988 Sep-Oct;19(5):279-81
TITLE:
[Multiple neurologic manifestations of Borrelia burgdorferi infection]
VERNACULAR TITLE:
Les multiples manifestations neurologiques des infections a Borrelia burgdorferi.
AUTHORS:
Dupuis MJ
AUTHOR AFFILIATION:
Clinique St-Pierre, Ottignies, Belgique.
ABSTRACT:
The neurological spectrum of Borrelia burgdorferi infections is still enlarging. We review epidemiological, pathological and serological data of Lyme disease. The course of the disease is divided in three stages: stage 1 during the first month is characterised by erythema chronicum migrans and associated manifestations; stage 2 includes not only the classical European meningoradiculitis but also less specific neurological symptoms: isolated lymphocytic meningitis with an acute or even relapsing course, apparently idiopathic facial palsy, neuritis of other cranial nerves, polyneuritis cranialis, Argyll-Robertson sign, peripheral nerve involvement, acute transverse myelitis, severe encephalitis, myositis. During stage 3, three to five months or longer after the onset of the disease, chronic arthritis, acrodermatitis chronica atrophicans and various neurological symptoms can be observed: chronic neuropathy with mainly sensory or motor signs, recurrent strokes due to cerebral angiopathy and progressive encephalomyelitis; this third stage the central nervous system involvement is characterised by slowly progressive or fluctuating course during months or years, ataxic or spastic gait disorder, bladder disturbances, cranial nerve dysfunction including optic atrophy and hypoacusia, dysarthria, focal and diffuse encephalopathy. This chronic central nervous system disease can mimic multiple sclerosis, anorexia nervosa, psychic disorders or subacute presenile dementia. It is often associated with pleiocytosis, abnormal EEG and evoked potentials, sometimes multifocal and mainly periventricular white matter lesions visualised by CT or MRI, and as a rule high antibody titers against Borrelia burgdorferi. High doses of penicillin can halt the disease, sometimes induce spectacular regression of symptoms or sometimes be inefficient; ceftriaxone could be a more powerful therapy. Similarities between syphilis and Borreliosis are multiple: both of these spirochetes contain plasmids, can be transmitted through the placenta and progress for many years through successive stages, with multiorgan symptoms, including parenchymatous and vascular lesions of the central nervous system. Borrelia burgdorferi is the new great imitator.
NLM PUBMED CIT. ID: 3070690 NLM CIT. ID: 89186273
SOURCE:
Rev Neurol (Paris) 1988;144(12):765-75
TITLE:
Lyme disease during pregnancy.
AUTHORS:
Markowitz LE; Steere AC; Benach JL; Slade JD; Broome CV
ABSTRACT:
Lyme disease is an increasingly recognized tick-borne illness caused by a spirochete, Borrelia burgdorferi. Because the etiologic agent of Lyme disease is a spirochete, there has been concern about the effect of maternal Lyme disease on pregnancy outcome. We reviewed cases of Lyme disease in pregnant women who were identified before knowledge of the pregnancy outcomes. Nineteen cases were identified with onset between 1976 and 1984. Eight of the women were affected during the first trimester, seven during the second trimester, and two during the third trimester; in two, the trimester of onset was unknown. Thirteen received appropriate antibiotic therapy for Lyme disease. Of the 19 pregnancies, five had adverse outcomes, including syndactyly, cortical blindness, intrauterine fetal death, prematurity, and rash in the newborn. Adverse outcomes occurred in cases with infection during each of the trimesters. Although B burgdorferi could not be implicated directly in any of the adverse outcomes, the frequency of such outcomes warrants further surveillance and studies of pregnant women with Lyme disease.
NLM PUBMED CIT. ID: 2423719 NLM CIT. ID: 86227939
SOURCE:
JAMA 1986 Jun 27;255(24):3394-6
TITLE:
Fetal outcome in murine Lyme disease.
AUTHORS:
Silver RM; Yang L; Daynes RA; Branch DW; Salafia CM; Weis JJ
AUTHOR AFFILIATION:
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132.
ABSTRACT:
Lyme disease is an inflammatory syndrome caused by infection with Borrelia burgdorferi. Although this syndrome has important implications for human pregnancy, little is known about gestational infection with B. burgdorferi. Fetal death occurred in 33 of 280 gestational sacs (12%) in 39 C3H/HeN female mice infected by intradermal injection of B. burgdorferi 4 days after mating (acute infection), compared with 0 of 191 sacs in 25 control mice (P = 0.0001). Forty-six percent of acutely infected mice suffered at least one fetal death, compared with none of the control animals (P = 0.0002). There were no fetal deaths in 18 C3H/HeN mice infected 3 weeks prior to mating (chronic infection). A sensitive PCR technique detected B. burgdorferi DNA in the uteri of acutely infected mice but did not detect DNA in the uteri of controls or chronically infected mice. Spirochete DNA was only rarely detected in fetal tissues, and its presence was not required for fetal death. The inclusion of an internal competitive PCR target indicated that the lack of B. burgdorferi sequences in fetal DNA was not due to the presence of a PCR inhibitor. Histologic analysis of gestational tissues from infected animals demonstrated nonspecific pathology consistent with fetal death. These findings indicate an association between murine fetal death and acute infection with B. burgdorferi early in gestation but not with chronic infection. Our data suggest that fetal death is due to a maternal response to infection rather than fetal infection. These findings could provide an explanation for observations in humans in which sporadic cases of fetal death in women infected with B. burgdorferi during pregnancy have been reported, while previous infection has not been associated with fetal death.
NLM PUBMED CIT. ID: 7806385 NLM CIT. ID: 95105028
SOURCE:
Infect Immun 1995 Jan;63(1):66-72
TITLE:
Intrauterine transmission of Borrelia burgdorferi in dogs.
AUTHORS:
Gustafson JM; Burgess EC; Wachal MD; Steinberg H
AUTHOR AFFILIATION:
Department of Medical Sciences, University of Wisconsin-Madison, School of Veterinary Medicine 53706.
ABSTRACT:
To determine whether intrauterine transmission of Borrelia burgdorferi could exist in dogs, 10 female Beagles were inoculated intradermally with approximately 1,000 B burgdorferi on day 1 of proestrus; inoculation was repeated every 2 weeks during the gestation period. Ten female control Beagles were similarly inoculated with phosphate-buffered saline solution. Prior to the start of the study, all females and 3 males used for breeding were seronegative for B burgdorferi on the basis of results of the indirect fluorescent antibody test and immunoblot (western analysis. Similarly, results of culture of blood for B burgdorferi were negative. All 20 of the females were bred naturally. Blood samples were collected weekly for serologic testing and culture. Blood samples were obtained from live pups on day 1 of life, then weekly until pups were 6 weeks old when they were euthanatized. Tissues were obtained for culture and testing by use of polymerase chain reaction (PCR). Of 10 spirochete-inoculated (SI) females, 8 became infected with B burgdorferi as evidenced by spirochete culture results and/or PCR-detected B burgdorferi DNA in the tissues of females or their pups. Of the 10 SI females, 8 delivered litters (3 to 7 pups) that had at least 1 neonatal or 6-week-old pup with B burgdorferi DNA-positive tissues (by PCR), and spirochetes were cultured from tissues from pups of 2 litters. (ABSTRACT TRUNCATED AT 250 WORDS)
NLM PUBMED CIT. ID: 8323057 NLM CIT. ID: 93311737
SOURCE:
Am J Vet Res 1993 Jun;54(6):882-90
TITLE:
Borrelia burgdorferi infection in dairy cows, rodents, and birds from four Wisconsin dairy farms.
AUTHORS:
Burgess EC; Wachal MD; Cleven TD
AUTHOR AFFILIATION:
Department of Medical Science, University of Wisconsin, School of Veterinary Medicine, Madison 53706.
ABSTRACT:
A combination of culture and subsequent spirochete identification with the polymerase chain reaction technique was used to identify cows, rodents, and birds infected with Borrelia burgdorferi. Animals were trapped on four Wisconsin dairy farms during the summer of 1990. Farms 1 and 2 were located in counties nonendemic for Lyme disease and Farms 3 and 4 were located in counties endemic for Lyme disease. The results of the rodent and bird samples were as follows given as the number yielding organisms number tested: Farm 1, 1/17 Mus musculus and 2/52 Peromyscus domesticus; Farm 2, 4/49 M. musculus, 1/2 P. maniculatus, 1/1 P. leucopus, and 1/35 P. domesticus; Farm 3, 0/27 M. musculus, 0/5 P. leucopus, 0/12 P. maniculatus and, 3/58 P. domesticus; and Farm 4, 1/24 M. musculus, 2/19 P. leucopus, 1/12 Microtus pennsylvanicus, and 0/17 P. domesticus. One P. leucopus and one M. musculus from Farm 2 were pregnant and fetal tissues from both were positive. Cow blood sample results were as follows: Farm 1, 7/47 in July, and 2/45 in August; Farm 2, 0/28 in August and 0/23 in October; Farm 3, 0/13 in July and 1/18 in August 29; and Farm 4, 3/45 in August. Ticks were found on rodents on Farm 4 and on one bird on Farm 3. Spirochetemic cows, rodents, and birds were found in non-Lyme endemic counties suggesting that alternate modes of transmission other than by ticks may be important. Transplacental transmission was shown in M. musculus and P. leucopus.
NLM PUBMED CIT. ID: 8362496 NLM CIT. ID: 93369938
SOURCE:
Vet Microbiol 1993 May;35(1-2):61-77
TITLE:
AUTHORS:
Burgess EC; Windberg LA
AUTHOR AFFILIATION:
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
ABSTRACT:
Coyotes (Canis latrans) from southern Texas were sampled for antibodies to Borrelia burgdorferi from 1980 to 1986; black-tailed jack rabbits (Lepus californicus) and desert cottontails (Sylvilagus audubonii) were sampled in 1986. Coyote fetuses, adult coyote kidneys, and black-tailed jack rabbit and desert cottontail kidneys were cultured for B. burgdorferi in 1986. Results of indirect immunofluorescent antibody (IFA) tests for B. burgdorferi in coyotes were as follows (number positive at a dilution of greater than or equal to 1:128/number tested): 1980 (0 of 30), 1981 (0 of 21), 1982 (0 of 53), 1983 (0 of 78), 1984 (47 of 97), 1985 (20 of 88), and 1986 (42 of 80). Eight of 26 black-tailed jack rabbits and two of seven desert cottontails tested in 1986 had IFA titers to B. burgdorferi of greater than or equal to 1:128. Borrelia burgdorferi was isolated from one of five coyote fetuses, three of 31 adult coyote kidneys, and two of 10 black-tailed jack rabbit kidneys in 1986. These results indicate that B. burgdorferi infection has been present in coyotes in Texas, at least since 1984 and that transplacental transmission occurs.
NLM PUBMED CIT. ID: 2644452 NLM CIT. ID: 89125773
SOURCE:
J Wildl Dis 1989 Jan;25(1):47-51
TITLE:
Borrelia burgdorferi infection in Wisconsin horses and cows.
AUTHORS:
Burgess EC
AUTHOR AFFILIATION:
School of Veterinary Medicine, University of Wisconsin, Madison 53706.
ABSTRACT:
Blood samples from Wisconsin horses and cows suspected of having clinical disease due to Borrelia burgdorferi infection were submitted by veterinary practitioners. All serum, milk, colostrum, and synovial samples were tested for B. burgdorferi antibodies by immunofluorescence. Whole blood, milk, colostrum, and synovial fluid samples were cultured for B. burgdorferi. Records were kept on the clinical signs of antibody-positive animals, date of sample, and location of the animal by county. Of the samples tested for antibodies 282/430 cow sera, 118/190 horse sera, 5/10 cow synovial fluids, 3/6 horse synovial fluids, 2/3 cow colostrums, 0/44 cow milk samples and 1 aborted fetus serum were antibody positive at a titer of 1:128 or greater. Of samples cultured 7/156 cow bloods, 2/35 horse bloods, 1/14 cow synovial fluids, 0/4 synovial fluids, 1/3 cow colostrums, 0/44 cow milk, and 2/10 cow urine samples were B. burgdorferi culture positive. For both cows and horses October and May were the two peak months for the number of antibody-positive samples. The most frequent clinical signs in antibody-positive horses and cows were lameness and swollen joints, but many also had stiffness, laminitis, abortions, and fevers. Not all antibody-positive animals showed clinical signs. These findings show that B. burgdorferi infection occurs in horses and cows and can cause clinical illness in some but not all animals. Infection in cows and horses occurs most frequently 1 month after the emergence of adult I. dammini. Because spirochetes could be isolated from blood, synovial fluid, colostrum, and urine, these animals could be important in providing an infected blood meal for ticks and bringing B. burgdorferi in direct contact with humans.
NLM PUBMED CIT. ID: 3190095 NLM CIT. ID: 89048796
SOURCE:
Ann N Y Acad Sci 1988;539:235-43
TITLE:
AUTHORS:
Anderson JF; Johnson RC; Magnarelli LA
ABSTRACT:
Borrelia burgdorferi, the etiologic agent of Lyme disease, was isolated from 111 of 237 Peromyscus leucopus captured during all seasons of the year. Borreliae were cultured from tissues of the spleen (101 mice), left kidney (76 mice), and right kidney (73 mice), from blood (12 mice), and from one fetus. Mice were infected during the winter, when immature Ixodes dammini were inactive. The prevalence of infection during the winter (less than or equal to 33%) was more than twofold lower than that during the summer (ca. 75%), a time when nymphal ticks are abundant. Overwintering, infected mice are reservoir hosts for subadult ticks that begin feeding in early spring. Twenty white-footed mice from which B. burgdorferi was isolated from tissues of spleen or kidney but not from blood were parasitized by larval I. dammini or Dermacentor variabilis which harbored borreliae. We conclude that these mice were infectious to feeding ticks, even though borreliae were not isolated from blood.
NLM PUBMED CIT. ID: 3624451 NLM CIT. ID: 87308743
SOURCE:
J Clin Microbiol 1987 Aug;25(8):1564-6
TITLE:
Update: Lyme disease and cases occurring during pregnancy--United States.
See full-text article at:
CDC MMWR: Lyme Disease and Cases Occurring during Pregnancy -- US, June 28, 1985
NLM PUBMED CIT. ID: 3925314 NLM CIT. ID: 85240257
SOURCE:
MMWR Morb Mortal Wkly Rep 1985 Jun 28;34(25):376-8, 383-4
[No abstract available.]
TITLE:
Neonatal skin lesions due to a spirochetal infection: a case of congenital Lyme borreliosis?
AUTHORS:
Trevisan G; Stinco G; Cinco M
AUTHOR AFFILIATION:
Institute of Dermatology, University of Trieste, Italy.
NLM PUBMED CIT. ID: 9352409 NLM CIT. ID: 98013686
SOURCE:
Int J Dermatol 1997 Sep;36(9):677-80
[No abstract available.]
TITLE:
[Pathology of pregnancy and the fetus in Lyme disease]
VERNACULAR TITLE:
Patologiia beremennosti i ploda pri bolezni Laima.
AUTHORS:
Elsukova LV; Korenberg EI; Kozin GA
NLM PUBMED CIT. ID: 7715559 NLM CIT. ID: 95231409
SOURCE:
Med Parazitol (Mosk) 1994 Oct-Dec;(4):59-62
[No abstract available.]
TITLE:
AUTHORS:
NLM PUBMED CIT. ID: 1358705 NLM CIT. ID: 93050632
SOURCE:
Int J Gynaecol Obstet 1992 Sep;39(1):59-60
[No abstract available.]
TITLE:
Lyme disease: a review with emphasis on the pregnant woman.
AUTHORS:
Smith LG Jr; Pearlman M; Smith LG; Faro S
AUTHOR AFFILIATION:
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030.
NLM PUBMED CIT. ID: 2014072 NLM CIT. ID: 91194878
SOURCE:
Obstet Gynecol Surv 1991 Mar;46(3):125-30
[No abstract available.]
TITLE:
Lyme disease during pregnancy.
AUTHORS:
Edly SJ
AUTHOR AFFILIATION:
Department of Obstetrics and Gynecology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903.
NLM PUBMED CIT. ID: 2200981 NLM CIT. ID: 90349122
SOURCE:
N J Med 1990 Jul;87(7):557-60
TITLE:
Lyme borreliosis during pregnancy.
AUTHORS:
Stiernstedt G
AUTHOR AFFILIATION:
Department of Infectious Diseases, Danderyd Hospital, Sweden.
NLM PUBMED CIT. ID: 2287925 NLM CIT. ID: 91142741
SOURCE:
Scand J Infect Dis Suppl 1990;71:99-100
[No abstract available.]
TITLE:
AUTHORS:
Cartter ML; Hadler JL; Gerber MA; Mofenson L
NLM PUBMED CIT. ID: 2758822 NLM CIT. ID: 89337701
SOURCE:
Conn Med 1989 Jun;53(6):341-2
[No abstract available.]
TITLE:
Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy.
AUTHORS:
Weber K; Bratzke HJ; Neubert U; Wilske B; Duray PH
AUTHOR AFFILIATION:
Department of Medicolegal Medicine, Dermatology and Microbiology, University of Munich, Federal Republic of Germany.
NLM PUBMED CIT. ID: 3130607 NLM CIT. ID: 88217405
SOURCE:
Pediatr Infect Dis J 1988 Apr;7(4):286-9
[No abstract available.]
TITLE:
VERNACULAR TITLE:
Lymska nemoc v tehotenstvi.
AUTHORS:
Andrasova V; Svarovsky J; Matousek B
NLM PUBMED CIT. ID: 3370692 NLM CIT. ID: 88223439
SOURCE:
Cesk Gynekol 1988 Feb;53(1):39-41
[No abstract available.]
TITLE:
Stillbirth following maternal Lyme disease.
AUTHORS:
MacDonald AB; Benach JL; Burgdorfer W
NLM PUBMED CIT. ID: 3480464 NLM CIT. ID: 88095529
SOURCE:
N Y State J Med 1987 Nov;87(11):615-6
[No abstract available.]
TITLE:
Lyme disease during pregnancy.
AUTHORS:
Mikkelsen AL; Palle C
AUTHOR AFFILIATION:
Department of Gynecology and Obstetrics, Hvidovre Hospital, University of Copenhagen, Denmark.
NLM PUBMED CIT. ID: 3425250 NLM CIT. ID: 88102547
SOURCE:
Acta Obstet Gynecol Scand 1987;66(5):477-8
[No abstract available.]
TITLE:
Human fetal borreliosis, toxemia of pregnancy, and fetal death.
AUTHORS:
MacDonald AB
NLM PUBMED CIT. ID: 3554838 NLM CIT. ID: 87208538
SOURCE:
Zentralbl Bakteriol Mikrobiol Hyg [A] 1986 Dec;263(1-2):189-200
[No abstract available.]
TITLE:
Leads from the MMWR. Update: Lyme disease and cases occurring during pregnancy.
NLM PUBMED CIT. ID: 4009904 NLM CIT. ID: 85237877
SOURCE:
JAMA 1985 Aug 9;254(6):736-7, 741
[No abstract available.]
TITLE:
Maternal-fetal transmission of the Lyme disease spirochete, Borrelia burgdorferi.
AUTHORS:
Schlesinger PA; Duray PH; Burke BA; Steere AC; Stillman MT
NLM PUBMED CIT. ID: 4003991 NLM CIT. ID: 85223525
SOURCE:
Ann Intern Med 1985 Jul;103(1):67-8
[No abstract available.]
For more information on pregnancy and Lyme disease, see:
Pregnancy and Lyme disease
http://www.reocities.com/HotSprings/Oasis/6455/pregnancy-links.html
This document can be found at:
Pregnancy Complications and Lyme disease - A Bibliography with Highlighted Full Abstracts
http://www.reocities.com/HotSprings/Oasis/6455/pregnancy-special-abstracts.html
See other annotated bibliographies on Lyme disease issues at:
Annotated Bibliographies of Medical and Scientific Articles on Lyme Disease Issues
http://www.reocities.com/HotSprings/Oasis/6455/bibliographies-links.html
For more information about Lyme disease, see:
Lots Of Links On Lyme Disease
http://www.reocities.com/HotSprings/Oasis/6455/lyme-links.html
Comments or questions concerning this page should be directed to Art Doherty.
Last updated on 23 June 2000 by
Art Doherty
Lompoc, California
doherty@utech.net
Original Link Here: http://www.reocities.com/HotSprings/Oasis/6455/pregnancy-special-abstracts.html