Producing enough food while leaving space for nature will be one of the major challenges faced by humanity over the course of this century, particularly as the climate continues to warm. Growing higher-value crops typically requires less land, permitting more land to be devoted to conserving biodiversity. Future climate change may create opportunities to grow novel, high-value crops in areas which were previously too cold. As these species originate from warmer climates, they may require more specific microclimate conditions than traditional crop varieties. To realise the potential to grow them, we must therefore identify where the best locations will be. This research will develop and apply the latest high-resolution microclimate models to identify places that are most climatically conducive to growing a range of novel crops, using Cornwall and the Isles of Scilly as a case study. This region is particularly suitable for the study of microclimate and agriculture due to a rarity of frosts and growing interest in the production of small-scale, high-value niche products. We hope to help resolve conflicts between farming and biodiversity and suggest practical solutions to the issue food security which can be applied globally.