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Melanie Ganz.mp4Project "How can you avoid to put children with cerebral palsy in general anesthesia while they are in a brain scanner?" funded by the Elsass Foundation
In spring 2018 I received nearly 3.9 mio DKK from Elsass Foundation for the project "How can you avoid to put children with cerebral palsy in general anesthesia while they are in a brain scanner?" which will be hosted at NRU starting in April 2019 and running through March 2022.
Project abstract:
Project abstract:
It is standard procedure in most Danish hospitals to employ general anesthesia when small children are in need of medical imaging procedures that demand anesthesia. Anesthesia is used to prevent the child from leaving the scanner, to reduce motion artefacts and for dealing with children that are too anxious to enter the scanning environment. Movement during the image acquisition can cause serious distortions of the imaging data, which can invalidate its quality and potentially lead to an erroneous conclusion. Even though complications directly related to general anesthesia are rare, there is an increasing concern about the potential neurotoxic effects of general anesthesia. Additionally, there are logistic and financial challenges associated with the use of general anesthesia.
The aim of our project is to utilize recent developments in medical imaging hardware technology in order to show that most young children can undergo medical imaging procedures without anesthesia and that it is still possible to obtain a high-quality diagnostic scan. We want to test the clinical efficacy of a marker-less motion tracking device that can register the child’s movements while scanning which allows for motion correction of the acquired images.
Our goal is to demonstrate the clinical utility of a novel approach of imaging including training, preparation and the use of the tracking device in children with cerebral palsy that undergo MRI scans for diagnostic purposes. Results from this project can be used when the new dedicated childhood brain damage MRI system funded by the Elsass Foundation is installed at BørneRiget, the new Mary Elizabeth childrens’s hospital to open in Copenhagen in 2026.
Meet the Team:
Meet the Team:
Project PI
Melanie Ganz
Researcher, NRU, Rigshospital
Project Co-PI
Alfred Peter Born
Overlæge, Juliane Maries Center, Rigshospital
Project Nurse
Thurid Waagenstein
Nurse practitioner, Rigshospital
Collaborators:
Collaborators:
Andre van der Kouwe
A. A. Martinos Center for Biomedical Imaging, MGH
Stephen Robert Frost
A. A. Martinos Center for Biomedical Imaging, MGH
Vibeke André Larsen
Head of Radiology, Rigshospital
Project researcher
Kathrine Skak Madsen
Lektor, Professionshøjskolen Metropol
Lise Borgwardt
Overlæge, Rigshospital
Nitesh Shekhrajka
Neuroradiologist, Rigshospital
Alumni:
Alumni:
Physicist
Hannah Eichhorn
Niels Bohr Institute, University of Copenhagen
Student worker
Maria Christiansen
BSc psychology, University of Coepnhagen
Student worker, MSc student
Kathrine Christensen
MSc psychology, University of Copenhagen
MSc student
Evangelos Vouros
Niels Bohr Institute, University of Copenhagen
MSc student
Simon Chemnitz Thompsen
Department of Computer Science, University of Copenhagen
Project Nurse
Asta Kongsgaard
Nurse practitioner, Rigshospital
BSc student
Bianca Pedersen
Radiography, KP Metropol
BSc student
Martin Riis Rassing
Radiography, KP Metropol
MSc student
Andreea-Veronica Vascan
Datalogisk Institut, University of Copenhagen
Project Nurse
Ditte Busk Nielsen
Nurse practitioner, Rigshospital
Publications and invited talks
Publications and invited talks
We have been presenting our work at in invited talks, at several conferences and also published scientific articles:
Invited talks:
Invited talks:
ISMRM Motion Correction workshop 2024
Melanie presented an invited talk with the title "Image Quality Metrics for Motion Assessment " at the ISMRM Motion Correction workshop 2024.
FLUX and FIT'NG 2023
Melanie participated in the FLUX conference 2023 (https://fluxsociety.org/2023-santa-rosa/) as a speaker in the symposium "Emerging Methods for MRI in Infants and Young Children" together with Rhodri Cusack, Cameron Ellis, Brittany Howell and Aine Dineen. All content is accessible in this OSF repository: https://osf.io/x9j7p/
ISMRM Motion Correction workshop 2022
Melanie presented an invited talk with the title "Characterisation of Children's Head Motion for Magnetic Resonance Imaging With & Without General Anaesthesia " at the ISMRM Motion Correction workshop 2022.
Conference abstracts:
Conference abstracts:
FLUX and FIT'NG 2024
Thurid will present an abstract at FLUX and FIT'NG 2024 with the title "Behavioral strategies to minimize head motion reduce the need for general anesthesia in pediatric patients undergoing cerebral MRI", M. Ganz, T. W. Madsen, A. P. Born, T. Gaas, R. Frost, A. van der Kouwe, V. A. Larsen
ISMRM Motion Correction workshop 2024
The MoCo project was represented heavily at the ISMRM MoCo workshop . We presented three abstracts and participated in a fourth:
1) Generative Models for Children’s Head Motion in Resting-State Functional Magnetic Resonance Imaging (rs-fMRI), H. A. Georgiev, J. F. Sheye, V. Beliveau, M. Ganz
2) Head Movement in the Resting-State Functional Magnetic Resonance Imaging (rs-fMRI) Data of the Adolescent Brain Cognitive Development (ABCD) Study
J. F. Sheye, H. A. Georgiev, M. Ganz
3) Simulating Head Motion in MRI: A Silicone Phantom Approach with Machine Learning Integration, M. Daugaard, E. Riis-Jacobsen, H. Yin, K. Erleben, M. Ganz
4) Hybrid Motion Correction: Combining Prospective & Retrospective Motion Correction, M. Laustsen, S. Glimberg, J. Slipsager, R. Frost, M. Ganz, A. van der Kouwe, T. Gaass
ISMRM 2024
Assessing Image Quality Metric Alignment with Radiological Evaluation in Datasets with and without Motion Artifacts, E. Marchetto, H. Eichhorn, D. Gallichan, S. T. Schwarz, N. Shekhrajka, M. Ganz
Hybrid Motion Correction: Prospective Thresholding and Retrospective Residual Correction, S. Glimberg, M. Laustsen, J. Slipsager, R. Frost, M. Ganz, A. van der Kouwe, T. Gaass
Hybrid Motion Correction: Latency Compensation In The Presence Of Respiratory Motion, M. Laustsen, T. Gaass, J. Slipsager, R. Frost, M. Ganz, A. van der Kouwe, S. Glimberg
FLUX and FIT'NG 2023
Reducing the Need for General Anesthesia in Children Undergoing Neuroimaging by Preparation and Motion Correction , M. Ganz, T. Waagstein Madsen, K. Søndergaard Christensen, K. Skak Madsen, A. Peter Born, V. Andrée Larsen
ISMRM 2023
Selective MRI reacquisition to extend the working range of retrospective motion correction, M. Laustsen, J. Slipsager, T. Gaaß, A. Van der Kouwe, M. Ganz, L. G Hanson
ISMRM 2022
H. Eichhorn, S. Chemnitz-Thomsen, E. Vouros, N. Shekhrajka, R. Frost, A. van der Kouwe, M. Ganz
Articles:
Articles:
H. Eichhorn, A. Vascan, M. Nørgaard, A. H. Ellegaard, J. M. Slipsager, S. Høgild Keller, L. Marner, M. Ganz
Preprints:
Preprints:
Evaluating the performance of markerless prospective motion correction and selective reacquisition in a general clinical protocol for brain MRI
H. Eichhorn, R. Frost, A. Kongsgaard, K. Kettless, J. Slipsager, S. Glimberg, N. Shekhrajka, M. D. Tisdall, P. Wighton, L. Borgwardt, A. P. Born, V. Andrée Larsen, K. Skak Madsen, A. van der Kouwe, M. Ganz
Media coverage
Media coverage
We have been covered in several news outlets:
DR:
On January 14th 2020, we were very shortly featured in the national evening news. The head of NRU, Gitte Moos Knudsen, was contacted to show off the NRU scanner and she decided to focus on our project in order to tell why this scanner was so special! So you can see Gitte showing and describing the prospective motion correction abilities the new scanner has (on a picture of my brain ) and me walking around operating Tracoline. It can be found here around minute 8:15: https://www.dr.dk/drtv/se/tv-avisen-21_00_-fuld-opbakning-til-venstres-formand_162641
IndenRigs:
Our motion correction project was featured on the backside of Rigshospitalet's IndenRigs magazine in December 2020. The article generated quite a bit of interest on social media, see Facebook
Legeskanner er ikke for sjov (Nov. 2021)
Smart kamera sparer børn for fuld narkose (Dec. 2020)
Siemens:
Our mock scanner is featured in the August 2021 Next level magazine by Siemens. You can read our article titled "Mock-up MR scanner helps to reduce anxiousness for children" here.
Related work
Related work
We hosted a Miccai 2021 challenge as well as a second round at MedNeurIPS 2021. The challenge website has more details: https://realnoisemri.grand-challenge.org/.
The data for the challenge has since been released in OpenNeuro: https://openneuro.org/datasets/ds004332 and can be directly accessed from there.
If you'd also like to get access to k-space data, please contact us, since those data could not be anonymized.
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