In the start of April I have received nearly 3.9 mio DKK from Elsass Foundation for my new 3-year project "How can you avoid to put children with cerebral palsy in general anesthesia while they are in a brain scanner?" which will be hosted at the Neurobiology Research Unit at Rigshsopital starting in April 2019.
It is standard procedure in most Danish hospitals to employ general anesthesia when small children are in need of medical imaging procedures that demand anesthesia. Anesthesia is used to prevent the child from leaving the scanner, to reduce motion artefacts and for dealing with children that are too anxious to enter the scanning environment. Movement during the image acquisition can cause serious distortions of the imaging data, which can invalidate its quality and potentially lead to an erroneous conclusion. Even though complications directly related to general anesthesia are rare, there is an increasing concern about the potential neurotoxic effects of general anesthesia. Additionally, there are logistic and financial challenges associated with the use of general anesthesia.
The aim of our project is to utilize recent developments in medical imaging hardware technology in order to show that most young children can undergo medical imaging procedures without anesthesia and that it is still possible to obtain a high-quality diagnostic scan. We want to test the clinical efficacy of a marker-less motion tracking device that can register the child’s movements while scanning which allows for motion correction of the acquired images.
Our goal is to demonstrate the clinical utility of a novel approach of imaging including training, preparation and the use of the tracking device in children with cerebral palsy that undergo MRI scans for diagnostic purposes. Results from this project can be used when the new dedicated childhood brain damage MRI system funded by the Elsass Foundation is installed at BørneRiget, the new childrens’s hospital to open in Copenhagen in 2024.
We will also present our work on "The Impact of Preprocessing Pipeline Choice in Univariate and Multivariate Analyses of PET Data" at the 8th International Workshop on Pattern Recognition in Neuroimaging (http://sites.google.com/site/prnisg2018/) taking place from June 12th-14th, 2018 in Singapore.
We will present our work on "False Positive Rates in PET" at the Neuro Recpetor Mapping meeting (http://www.nrm2018.org/nrm-conference/) taking place from July 9th – 12th, 2018 in London.
We just published a review titled "Cerebral serotonin transporter measurements with [11C] DASB: A review on acquisition and preprocessing across 21 PET centres" in the journal for cerebral blood flow and metabolism. Full text is available here: http://journals.sagepub.com/doi/full/10.1177/0271678X18770107
We published a journal paper regarding the study on seasonal affective disorder presented at OHBM with the tile "Brain Networks Implicated in Seasonal Affective Disorder: A Neuroimaging PET Study of the Serotonin Transporter" in Frontiers in Neuroscience. Full text is available here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682039/
We presented our work titled "Brain Networks involved in Seasonal Affective Disorder: A Neuroimaging PET Study of 5-HTT Expression" at OHBM June 25-29 2017 in Vancouver, Canada. Please find the abstract and poster below.
We presented our paper titled "Permutation tests for classification:Revisited" at the 2017 International Workshop on Pattern Recognition in Neuroimaging (PRNI). You cand find a preprint of the paper and the presentation from PRNI below.
Starting from May 2017, I will spend my time split between the Department for Computer Science of the University of Copenhagen (DIKU) where I recently got an appointment as assistant professor and the Neurobiology Research Unit (NRU) at Rigshsopital. My time at DIKU will be evenly divided between teaching (mainly in the fall) and establishing new research collaborations between the hospital and the university.
My fascination with the cerbellum is ongoing and we have published a study titled "Cerebellar heterogeneity and its impact on PET data quantification of 5-HT receptor radioligands" in the journal for cerebral blood flow and metabolism. Full text is available here: http://journals.sagepub.com/doi/full/10.1177/0271678X16686092