The Agile and Lean concepts of business methods can be seen as superheroes in the world of business strategy. Enterprise Architecture, which is often imagined to be the plan for how a business works, and Digital Transformation are closely associated. Visualize Agile and Lean as experienced and dynamic team players, who keep adjusting, demonstrating best practice, and recalibrating the game plan throughout the game. Meanwhile, Enterprise Architecture is the experienced coach, who keeps everyone alive in the game. There is a concentration on how teamwork, lean and agile are in tune with the EA's organization and optimization mainly by putting efficiency and customers' satisfaction key point. Agile principles make it possible for their software and services team to adopt an iterative approach with much faster response to customers' changing needs, which enables bringing healthcare technology solutions and services to the market in shorter time. Likewise, Lean principles operate a process of continuous improvement and, consequently, waste removal that aims at the optimization of supply chain management and workflow operations. Through the integration of Agile and Lean approaches, McKesson brings out innovations, facilitates a streamlined work systems with adequate speed, and gives value to its customers and other stakeholders within this healthcare industry.