The foundation of CircO2 began with one of the most celebrated breakthroughs in modern cardiovascular science: the 1998 Nobel Prize in Physiology or Medicine, awarded to researchers Robert Furchgott, Louis Ignarro, and Ferid Murad for discovering that Nitric Oxide (N.O.) acts as the primary signaling molecule causing blood vessels to dilate and relax.

However, clinical practitioners at Advanced Bionutritionals—led by integrative medical pioneer Dr. Frank Shallenberger, MD and classical herbal clinician Dr. Janet Zand, OMD—observed a severe obstacle when treating patients over 40:

1. The Age-Related Nitric Oxide Drop: By age 40, the body’s endothelial lining produces roughly 50% less nitric oxide than in youth; by age 60, that production drops by up to 85%.

2. The "eNOS" Enzyme Failure: Most commercial cardiovascular supplements rely on swallowed L-Arginine. But in mature bodies, the endothelial enzyme needed to convert L-arginine into nitric oxide (endothelial nitric oxide synthase, or eNOS) has largely deteriorated or uncoupled, leaving swallowed arginine virtually ineffective.

Recognizing that older adults could not depend on the failing eNOS pathway inside their blood vessel walls, the Advanced Bionutritionals clinical team utilized an alternative biological route: the salivary oral-microbiome pathway. By formulating a dissolvable lozenge that combines calibrated botanical nitrates, L-Citrulline, and antioxidant cofactors, they created a delivery mechanism that converts into active nitric oxide gas right on the tongue—bypassing both the stomach and failing endothelial enzymes to restore micro-capillary circulation.

• Nitric Oxide Precursor Matrix (Standardized Beet Root Powder & Calibrated Mineral Nitrites) - Direct Salivary N.O. Generator - Dissolves on the tongue to interact with oral bacteria and saliva, converting immediately into active nitric oxide gas. This bypasses damaged endothelial eNOS enzymes, dilating micro-capillaries within minutes to improve oxygen and nutrient delivery throughout the body.

• L-Citrulline - Sustained Nitric Oxide Recycler - Absorbs rapidly through the oral mucosa and digestive tract, converting into L-arginine within the kidneys. This maintains prolonged plasma arginine levels, ensuring continuous, sustained nitric oxide synthesis over 12 to 24 hours.

• Hawthorn Berry Extract (Crataegus oxyacantha) - Coronary Vasodilator & Cardioprotective Botanical - Rich in bioflavonoids and oligomeric proanthocyanidins (OPCs) that strengthen myocardial contractions, improve coronary arterial blood flow, and support healthy blood pressure metrics.

• Vitamin C (as Ascorbic Acid, 200 mg) - Nitric Oxide Preserver & Antioxidant Shield - Prevents the rapid destruction of newly created nitric oxide by neutralizing superoxide free radicals. Ascorbic acid also enhances the biochemical reduction of nitrite into bioactive nitric oxide gas.

• Vitamin B12 (as Methylcobalamin, 1,000 mcg) - Bio-Identical Oxygen Carrier & Methylator - Essential for the synthesis of healthy red blood cells responsible for transporting oxygen to peripheral tissues. Also regulates homocysteine levels to protect the delicate endothelial lining from vascular lesions.

• Magnesium (as Magnesium Oxide & Glycinate Chelate, 100 mg) - Vascular Smooth Muscle Relaxer - Competes with intracellular calcium to relax the smooth muscle cells surrounding arterial walls, helping reduce arterial stiffness, support vascular flexibility, and ease muscle cramps. 

Q1: Why is CircO2 formulated as a quick-dissolve lozenge instead of a swallowed pill?

A: When you swallow a standard pill, it must pass through harsh stomach acid and liver breakdown. More importantly, older blood vessels lack the healthy enzymes required to convert swallowed ingredients like L-arginine into nitric oxide. CircO2 dissolves on your tongue, where natural enzymes in your saliva immediately convert the nutrients into active nitric oxide gas. This allows it to absorb directly through the oral mucosa into the bloodstream in minutes.

Q2: What are the telltale signs of low nitric oxide levels?

A: Because nitric oxide governs blood flow to every organ, common signs of deficiency include:

• Cold, tingling hands and feet due to poor peripheral micro-circulation.

• Midday brain fog and sluggish memory recall from reduced cerebral oxygenation.

• Sluggish physical stamina, heavy legs during walking, and prolonged recovery times.

• Elevated blood pressure readings as arteries lose their elasticity and become stiff.

Q3: How is CircO2 different from plain beet juice or beet powders?

A: Raw beets contain varying, unpredictable levels of dietary nitrates, and drinking sugary beet juices can cause unwanted glucose spikes. CircO2 provides a standardized, concentrated dose of botanical nitrates paired with L-Citrulline, Hawthorn Berry, Magnesium, Vitamin C, and B12. This synergistic combination not only creates nitric oxide on contact, but also protects it from free-radical oxidation, keeping it active in your bloodstream significantly longer.

Q4: How quickly does CircO2 begin working in the body?

A: Because it activates in the mouth rather than the stomach, nitric oxide levels begin to elevate within minutes. Many users who use nitric oxide saliva test strips see their readings move into the optimal "Target Zone" within 20 to 30 minutes after dissolving a single lozenge.

Q5: How should CircO2 be taken for best results?

A: Dissolve one (1) lozenge slowly in your mouth daily—do not swallow it whole or chew it. Allow it to move around the tongue so your saliva can activate the nitric oxide reaction. Taking it first thing in the morning provides sustained cardiovascular support, mental clarity, and physical energy throughout your day.

Q6: What is the refund policy on Digistore24?

A: Every order of CircO2 placed through the official Advanced Bionutritionals portal via Digistore24 is backed by an unconditional 90-Day "Down-to-the-Last-Pill" Money-Back Guarantee. You can test the product for a full 3 months; if you do not experience warmer extremities, improved stamina, and clearer thinking, you can return your empty boxes for a 100% refund of the product purchase price.