The formulation of SelfPlus AGE+ arose from a persistent challenge in nutritional longevity science: the bioavailability and dosage gap surrounding resveratrol.

Resveratrol gained global attention following scientific investigations into the "French Paradox"—the observation that certain European populations maintained cardiovascular and cellular vitality despite rich diets, partially attributed to red wine consumption. However, clinical researchers quickly identified two fundamental limitations:

1. Trace Concentrations in Food: Red wine contains only minuscule amounts of resveratrol (typically 0.2 to 2 mg per liter), meaning a consumer would have to consume hundreds of glasses daily to achieve biologically meaningful levels—an impossible and unhealthy prospect.

2. Poor Standardization in Early Supplements: Early market formulas relied on crude grape skin powders or unstandardized extracts containing unstable cis-resveratrol isomers, which offer minimal biological activity compared to the stable, bioactive trans-resveratrol form.

To solve this, Wellora Wellness LLC developed SelfPlus AGE+ by bypassing grape byproduct waste and sourcing from Japanese Knotweed (Polygonum cuspidatum)—the plant kingdom's richest, most resilient natural reservoir of trans-resveratrol. By standardizing the root extract to a verified 50% trans-resveratrol yield (125 mg active compound per single capsule), the product was designed to deliver a precise, once-daily antioxidant protocol tailored specifically for the modern healthy-aging demographic.

• Japanese Knotweed Root Extract (Polygonum cuspidatum) - 250 mg - Rich botanical reservoir providing natural phytoalexin defense compounds. Serves as the clean, sustainable source for concentrated polyphenol compounds without fruit sugars or alcohol byproducts.

• Standardized Trans-Resveratrol (50% Active Yield) - 125 mg - The biologically active, stable isomer of resveratrol. Crosses cellular boundaries to neutralize reactive oxygen species (ROS), stimulate cellular SIRT1 (sirtuin) signaling pathways, support mitochondrial biogenesis, and promote vascular nitric oxide production for healthy blood vessel flexibility.

• Vegetable Cellulose & Clean Excipients - Base Capsule Shell - Plant-derived capsule material and hypoallergenic inert flow agents ensuring rapid disintegration in the upper gastrointestinal tract within 15–20 minutes of ingestion. 

Q1: What is SelfPlus AGE+ and what is it used for?

A: SelfPlus AGE+ is a once-daily dietary supplement designed to support everyday cellular wellness, antioxidant defense, and healthy aging in adults. It delivers a standardized 125 mg dose of pure Trans-Resveratrol per capsule to help neutralize routine free radicals and support optimal micro-circulation throughout the body.

Q2: Why does SelfPlus AGE+ use Japanese Knotweed instead of red wine or grape seed?

A: Japanese Knotweed (Polygonum cuspidatum) is recognized in nutritional pharmacology as the most concentrated and bioavailable source of Trans-Resveratrol. Unlike grape seed or red wine extracts—which often yield only trace amounts of unstable polyphenols—Japanese Knotweed provides a stable, consistent 50% standardized yield, ensuring you get the exact 125 mg active compound in every single capsule.

Q3: Does SelfPlus AGE+ "reverse" or "stop" biological aging?

A: No. No dietary supplement can reverse, stop, or freeze biological aging. SelfPlus AGE+ is formulated to provide antioxidant and cellular nourishment that helps the body cope with routine oxidative stress and environmental wear. It is a proactive nutritional tool to support healthy aging, not a drug or cure.

Q4: How and when should I take SelfPlus AGE+?

A: The manufacturer recommends taking one (1) capsule once daily, approximately 20 to 30 minutes before a meal with an 8-ounce glass of water. Taking resveratrol shortly before a meal—especially one containing healthy dietary fats—helps facilitate optimal gastrointestinal uptake and absorption.

Q5: Is SelfPlus AGE+ approved by the FDA?

A: In accordance with the Dietary Supplement Health and Education Act (DSHEA) of 1994, dietary supplements are not subject to pre-market approval by the U.S. Food and Drug Administration (FDA). However, SelfPlus AGE+ is manufactured in accordance with strict Current Good Manufacturing Practices (cGMP) to verify ingredient identity, purity, and potency.

Q6: Can SelfPlus AGE+ ship internationally?

A: At this time, SelfPlus AGE+ is formulated, warehoused, and shipped exclusively within the United States. Orders with international delivery addresses cannot be fulfilled through the primary checkout funnel.

Q7: What is the refund policy on SelfPlus AGE+?

A: Every order of SelfPlus AGE+ completed through the official portal via Digistore24 is backed by a 60-Day 100% Money-Back Guarantee. If you are not satisfied with your purchase, you can contact customer support (support@selfplus-care.com or Digistore24 order assistance) within 60 days of purchase for refund processing.