Advanced Collagen Plus was developed under the medical direction of Advanced Bionutritionals, guided by integrative medical practitioners Dr. Frank Shallenberger, MD and Dr. Janet Zand, OMD.

The product was created to solve two major clinical flaws in conventional collagen supplementation:

1. The Molecular Weight Absorption Problem: Whole native collagen molecules are massive, rigid triple-helix proteins with a molecular weight of roughly 300,000 Daltons. When consumed in unhydrolyzed form (like cheap gelatin), the human gastrointestinal tract cannot absorb them intact; they are largely broken down into random, non-specific amino acids before reaching target connective tissues.

2. The "Single-Source" Limitation: Over 90% of commercial collagen brands utilize only bovine Type I and III collagen. While beneficial for skin dermis and bone structure, Type I and III do not supply the specific articular cartilage matrix needed by adults suffering from creaky, grinding joints and thinning synovial cushions.

To overcome these barriers, the Advanced Bionutritionals clinical board engineered a formula combining low-molecular-weight hydrolyzed bioactive peptides (broken down to roughly 2,000 to 5,000 Daltons for rapid transit through the gut barrier) with Type II sternal cartilage collagen, Hyaluronic Acid, and enzymatic Vitamin C. This structure was designed to simultaneously trigger fibroblast activity in the skin and stimulate chondrocyte repair in weight-bearing joint cartilage.

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• Hydrolyzed Bovine Collagen Peptides (Types I & III) - Low-Molecular Dermal & Bone Scaffolding -Rapidly absorbed di- and tri-peptides (proline-hydroxyproline) that accumulate in the skin dermis and extracellular matrix. They stimulate fibroblasts to synthesize new endogenous collagen fibers, strengthening skin tensile firmness, bone mineral scaffolding, and arterial elasticity.

• Hydrolyzed Avian Sternal Cartilage Extract (Type II Collagen) - Articular Cartilage Matrix - Specifically mirrors the exact collagen type found in human articular joints. Provides low-weight Type II peptides that signal chondrocytes to rebuild worn cartilage cushioning and reduce mechanical bone-on-bone friction.

• Hyaluronic Acid (Sodium Hyaluronate) - Synovial Viscosupplement - A natural glycosaminoglycan capable of retaining up to 1,000 times its weight in moisture within the synovial capsule. Lubricates articular joint surfaces, enhances shock absorption during movement, and plumps deep dermal crevices.

• Chondroitin Sulfate - Cartilage Defense Proteoglycan - Inhibits matrix metalloproteinases (destructive enzymes that degrade cartilage), attracts water and nutrients directly into the avascular joint matrix, and preserves flexible cartilage structure.

• Glucosamine Sulfate - Glycosaminoglycan Precursor - Serves as the primary biological building block for proteoglycans and synovial fluid, supporting the repair of damaged joint tissue and easing joint stiffness.

• Vitamin C (as Ascorbic Acid) - Essential Hydroxylation Coenzyme - A non-negotiable enzymatic cofactor for prolyl hydroxylase and lysyl hydroxylase. Without sufficient Vitamin C, the body cannot cross-link amino acids into stable, triple-helical collagen fibrils, rendering ingested collagen ineffective.

• Silica (from Bamboo / Horsetail Extract) -Connective Tissue Cross-Linker - Essential trace mineral that facilitates the synthesis of glycosaminoglycan networks, reinforcing structural hair thickness, nail tensile strength, and arterial wall resilience.

Q1: What makes Advanced Collagen Plus different from standard grocery-store collagen powders?

A: Most supermarket collagen products are single-source Type I bovine gelatin powders that lack joint-specific compounds and are too large for efficient intestinal absorption. Advanced Collagen Plus provides an enzymatically hydrolyzed multi-collagen formula combining Types I, III, and joint-specific Type II peptides with Hyaluronic Acid, Chondroitin, and Vitamin C to regenerate articular cartilage while firming skin elasticity.

Q2: Why is Type II collagen critical for joint stiffness?

A: While Types I and III provide structural strength to skin, tendons, and bones, articular cartilage inside human joints is composed predominantly of Type II collagen. Without bioavailable Type II peptides, the body lacks the specific signaling molecules and raw substrates required to stimulate chondrocytes and restore worn-down joint shock absorbers.

Q3: Why is Vitamin C included in the formula?

A: Collagen cannot be synthesized or cross-linked in the human body without Vitamin C. It serves as an essential enzymatic cofactor that converts proline and lysine into hydroxyproline and hydroxylysine—the chemical bonds that lock collagen fibers into strong triple-helices. Taking collagen without Vitamin C significantly impairs your body's ability to utilize the peptides.

Q4: How should Advanced Collagen Plus be used daily?

A: The manufacturer recommends taking the suggested daily serving with a full glass of water, preferably on an empty stomach or 30 minutes before a meal to ensure uninhibited peptide absorption through the intestinal wall without competing with heavy dietary proteins.

Q5: How soon can users expect visible results for joints and skin?

A: Synovial fluid replenishment and joint comfort improvements are commonly reported within 2 to 4 weeks of consistent daily use. Structural improvements in skin hydration, cuticle strength, and reduced fine lines typically become pronounced between 6 to 12 weeks as new dermal collagen fibers mature.

Q6: What is the refund policy on Digistore24?

A: All purchases of Advanced Collagen Plus made through the official Advanced Bionutritionals portal via Digistore24 are protected by an unconditional 90-Day "Down-to-the-Last-Pill" Money-Back Guarantee. You can test the product for a full three months; if you do not experience easier mobility and firmer skin, you can return your bottles (even if completely empty) for a full refund of the product purchase price.