Welcome to the Machin Laboratory at the University of New Mexico Health Sciences Center
Led by Dr. Daniel R. Machin, our laboratory is dedicated to advancing the understanding of vascular biology and cardiovascular physiology, with a particular focus on the endothelial glycocalyx—a gel-like layer lining blood vessels that plays a critical role in vascular health.
Our research explores how aging, diet, and disease contribute to vascular dysfunction, and we aim to uncover the molecular mechanisms behind these changes. We are especially interested in how hyaluronan, a key component of the glycocalyx, influences vascular integrity and function. Through innovative models and translational approaches, we investigate how interventions—such as high molecular weight hyaluronan administration—can restore glycocalyx structure and improve cardiovascular outcomes.
Glycocalyx degradation in aging and disease
High-sodium and Western diet-induced vascular changes
Endothelial cell signaling and transcriptomics
Vascular dysfunction in Down syndrome (TcMAC21 mouse model)
Therapeutic strategies targeting the glycocalyx
Our laboratory uses genetically diverse mouse models to better reflect human variability and uncover novel therapeutic targets. We are also committed to mentoring the next generation of scientists and fostering a collaborative research environment.
Discovery of early glycocalyx degradation following high-sodium diets
Identification of protective effects of high molecular weight hyaluronan
Insights into vascular physiology in Down syndrome models
Multiple NIH-funded projects, including a K99/R00 Pathway to Independence Award
We welcome inquiries from students, collaborators, and community members interested in cardiovascular research and translational science.