연사 소개

약력 

2023 ~                           Clinical Director of Epilepsy Division

                                         VP of Tianjin Medical University General Hospital

                                         VP of Tianjin Institute of Immunology, Tianjin, China

2018 ~                           Physician and Professor of Neurology      

                                        Director of Neurodegenerative Diseases Research Lab, VP of Tianjin     

                                        Neurological Institute,  Tianjin Medical University General Hospital, Tianjin,      

                                        China                                  

2017 ~ 2020               Arizona State University, Tempe, Arizona, USA           

                                       Adjunct Professor of Neuroscience Associate

2017 ~ 2019               University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA          

                                       Adjunct Professor of Neurology          

2016 ~ 2018               Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA                                         Tenure-Track Assistant Professor 

강의 제목

Bone Marrow Hematopoiesis in CNS Inflammation  

강의 내용

B cells drive the immunopathology of autoimmune diseases. Bone marrow hematopoietic stem and progenitor cells (HSPCs) sense immune activation and instruct systemic immunity. However, the alterations in HSPCs in B cell-mediated  autoimmune  diseases  and  their  impact  on  disease progression  remain  unknown.  Neuromyelitis  optica  spectrum  disorder (NMOSD) is a B cell-mediated autoimmune neurological disease that involves anti–aquaporin-4 autoantibodies (AQP4-IgG). Herein, we show aberrant  bone  marrow  granulopoiesis  in  patients  with  NMOSD, accompanied  by  the  expansion  of  B  cell  clones.  This  aberrant granulopoiesis  was  mediated  by  the  hyperactivity  of  the  JAK-STAT pathway,  leading  to  a  dramatic  increase  of  ISG15+  neutrophils  that produced BAFF to drive the maturation of antibody-secreting cells and AQP4-IgG production. This effect was also observed in patients with NMOSD receiving B cell depletion therapy who experienced relapse. In patients with NMOSD, belimumab, a monoclonal antibody against BAFF, reduced the rate of disease relapse, the number of antibody-secreting cells and the AQP4-IgG titer. Thus, targeting the bone marrow niche may present a new strategy for the treatment of NMOSD and perhaps other B cell- mediated autoimmune diseases.

관련 논문

1. Liu M, Wang D, Qi C, Zou M, Song J, Li L, Xie H, Ren H, Hao H, Yang G, Li Z, Zhang Q*, Zhou J*, Ai D*, Liu Q*. Brain ischemia sustains systemic endothelial Notch1 activity to accelerate atherosclerosis. Immunity. 2024 In press. *Co-corresponding authors.

2. Cui Z, Xu H, Wu F, Chen J, Zhu L, Shen Z, Yi X, Yang J, Jia C, Zhang L, Zhou P, Li MJ, Zhu L, Duan S, Yao Z, Yu Y*, Liu Q*, Zhou J*. Maternal circadian rhythm disruption affects neonatal inflammation via metabolic reprograming of myeloid cells. Nat Metab. 2024;6:899. *Co-corresponding authors. PMID: 38561509

3. Zhang W, Sun HS, Wang X, Dumont AS, Liu Q. Cellular senescence, DNA damage, and neuroinflammation in the aging brain. Trends Neurosci. 2024:S0166-2236(24)00061. PMID: 38729785

4. Cao Y, Li Y, Wang X, Liu S, Zhang Y, Liu G, Ye S, Zheng Y, Zhao J, Zhu X, Chen Y, Xu H, Feng D, Chen D, Chen L, Liu W, Zhou W, Zhang Z, Zhou P, Deng K, Ye L, Yu Y, Yao Z, Liu Q, Xu H, Zhou J. Dopamine  inhibits  group  2  innate  lymphoid  cell-driven  allergic  lung  inflammation  by  dampening mitochondrial activity. Immunity. 2023:S1074-7613(22)00675-6. PMID: 36693372

5. Shi K, Li H, Chang T, He W, Kong Y, Qi C, Li R, Huang H, Zhu Z, Zheng P, Ruan Z, Zhou J, Shi FD, Liu Q. Bone marrow hematopoiesis drives multiple sclerosis progression. Cell. 2022;185:2234-2247. PMID: 35709748