연사 소개

약력 

2023 ~                                        한국여성과학기술인육성재단(WISET)                           비상임이사                                 

2022 ~                                        경기도 환경보건위원회 위원        

2019 ~                                        식품의약품안전처 위해평가전문위원회 위원           

2018 ~                                        과총 국민생활과학자문단 화학물질 분과위원

2018 ~                                        환경부 생활화학제품 및 살생문제 관리위원회 위원     

2011  ~                                        한양대학교 약학과                                                                조교수/부교수/정교수

강의 제목

Unveiling the Cellular Defense: Mitochondria and Autophagy in Blood-Brain Barrier Vulnerability to External Stressors

강의 내용

This lecture explores the mechanisms and significance of blood-brain barrier (BBB) disruption caused by exogenous substances such as particulate matter and biocidal compounds in consumer products. For example, zinc oxide nanoparticles (ZnO-NPs) induce coagulant activity in red blood cells (RBCs) and excessive erythrophagocytosis, impairing BBB function. Additionally, the biocide CMIT/MIT damages mitochondrial function in brain endothelial cells and promotes oxidative stress and tight junction loss through autophagy imbalance. Examining these pathways provides insight into the cardiovascular and neurological risks these exogenous agents pose to BBB integrity and systemic health. 

관련 논문

1.  Promoted coagulant activity and disrupted blood-brain barrier depending on phosphatidylserine  externalization of red blood cells exposed to ZnO nanoparticles

• Kim EH et al., Environ Pollut., 2024, 10.1016/j.envpol.2024.124921

2.  Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats

• Kim EH et al., Part Fibre Toxicol., 2022, 10.1186/s12989-022-00500-y

3.  Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium

• Kim D et al., Toxocol Lett., 2022, 10.1016/j.toxlet.2022.06.010