연사 소개

 2019.04                Center for Neuroscience and Biomedical Engineering,               Professor 
                                  University of Electro-Communications

 2019.04                Keio University School of Medicine, Tokyo, Japan                         Visiting professor

 2017.04                 Faculty of Informatics and Engineering, University of                Professor
                                  Electro-Communications

 2011.01                  Faculty of Informatics and Engineering, University of               Associate Professor
                                  Electro-Communications

 2008.10                Center for Frontier Science and Education,                                    Assistant Professor
                                  University of Electro-Communications

 2006.10                Molecular Imaging Center, National Institute of                           Research Scientist
                                  Radiological Sciences, Chiba, Japan

 2003.10                 University of Pittsburgh, Pittsburgh, PA, USA                             Postdoctoral
                                                                                                                                                          Research Associate

Lecture Title

Optical Imaging and Manipulation of Brain Capillary Flow

Lecture Content 

Brain capillaries play a central role in maintaining neural functions by controlling molecular traffic through an interface between blood and brain tissue (i.e., blood-brain barrier). To better understand the regulatory dynamics of capillary flow, we employed optical imaging techniques (i.e., genetic sensors and two-photon microscopy) and optogenetic tools. The major findings are that the capillary flow is dynamically linked to the distribution of blood cells in the capillary network, and in close communication with perivascular cells (e.g., capillary pericytes and microglia). 

Other Related Paper

1. Murata J, Unekawa M, Kudo Y, Kotani M, Kanno I, Izawa Y, Tomita Y, Tanaka KF, Nakahara J, Masamoto K. Acceleration of the development of microcirculation embolism in the brain due to capillary narrowing. Stroke. 2023 Jun 13. doi: 10.1161/STROKEAHA.122.042416. Epub ahead of print. PMID: 37309687.

2. Suzuki H, Takeda H, Takuwa H, Ji B, Higuchi M, Kanno I, Masamoto K. Capillary responses to functional and pathological activations rely on the capillary states at rest. J Cereb Blood Flow Metab. 2023 Jun;43(6):1010-1024.

3. Niizawa T, Sakuraba R, Kusaka T, Kurihara Y, Sugashi T, Kawaguchi H, Kanno I, Masamoto K. Spatiotemporal analysis of blood plasma and blood cell flow fluctuations of cerebral microcirculation in anesthetized rats. J Cereb Blood Flow Metab. 2023 Jan;43(1):138-152.