연사 소개

[ 2차 온라인 심포지엄 ]

약력 

2020. 03 ~                                    연세의대 영상의학교실                                      조교수

2019. 03 ~ 2020. 02                  연세의대 영상의학교실                                     임상조교수

2018. 03 ~ 2019. 02                   강남세브란스병원                                             진료교수

2016. 03 ~ 2018. 02                   건국대학교 병원                                                임상조교수

2015. 03 ~ 2016. 02                   연세의대 영상의학교실                                     임상연구조교수

2014. 03 ~ 2015. 02                   연세의대 영상의학교실                                      강사

2010. 03 ~ 2014. 02                   세브란스병원 영상의학과                                  전공의

2009. 03 ~ 2010. 02                  세브란스병원                                                      인턴 

강의 제목

Meningeal Lymphatic Vessels and Neuroimaging

강의 내용

For a long time, it has been accepted that the brain does not comprise anatomic structures to process interstitial fluid. Unlike peripheral lymphatic system, immune cells as well as extracellular proteins are believed to be transported through the lymphatic system into the venous blood system. In 2013, M. Nedergaard et al. introduced a paravascular pathway potentially playing a major role as a clearing pathway for interstitial brain solutes entitled the “glymphatic system.”

Furthermore, a few years later, the existence of meningeal lymphatic vessels was first described by Aspelund et al. and Louveau et al. They both showed that the lymphatic system of the brain has important role in the drainage of ISF, potentially representing the extracrainal ISF drainage. This concept suggested a combined model of CSF/ISF drainage, currently labeled as the glymphatic-lymphatic fluid transport system. One of the important ISF protein is amyloid β, which is involved in the development of Alzheimer disease and therefore, it is believed that the glymphatic-lymphatic fluid transport system might involve the pathophysiological mechanism of Alzheimer disease.

Therefore, in the present lecture, we will provide a brief overview of recent updates of glymphatic-lymphatic fluid transport system and its relationship with aging and neurological disorders, especially focused on the in vivo monitoring of glymphatic-lymphatic fluid transport system using MRI.

관련 논문

1. Aspelund A, Antila S, Proulx ST, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015;212:991 – 999.

2. Martina Absinta, Seung-Kwon Ha, et al. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI Elife . 2017 Oct 3;6:e29738