業績

研究業績

〔学術論文〕

Diversity of Androgens; Comparison of Their Significance and Characteristics in Vertebrate Species.
Takashi Yazawa, Yoshitaka Imamichi, Takahiro Sato, Takanori Ida, Akihiro Umezawa, Takeshi Kitano
Zoological science 41(1) 77-86 2024年2月  

Expression and functional analyses for estrogen receptor and estrogen related receptor of Yesso scallop, Patinopecten yessoensis
Wenbin Gu, Tongchai Thitiphuree, Yurika Otoki, Emily C. Marquez, Takeshi Kitano, Naoki Itoh, Kazue Nagasawa, Makoto Osada
The Journal of Steroid Biochemistry and Molecular Biology 106302-106302 2023年3月

Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian Species.
Takashi Yazawa, Mohammad Sayful Islam, Yoshitaka Imamichi, Hiroyuki Watanabe, Kazuhide Yaegashi, Takanori Ida, Takahiro Sato, Takeshi Kitano, Shigenori Matsuzaki, Akihiro Umezawa …
Animals : an open access journal from MDPI 13(4) 2023年2月10日

Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent stem cells.
Takashi Yazawa, Yoshitaka Imamichi, Takeshi Kitano, Mohammad Sayful Islam, Md Rafiqul Islam Khan, Satoru Takahashi, Toshio Sekiguchi, Nobuo Suzuki, Akihiro Umezawa, Junsuke Uwada
Scientific Reports 13(1) 1611-1611 2023年1月28日

Amh/Amhr2 Signaling Causes Masculinization by Inhibiting Estrogen Synthesis during Gonadal Sex Differentiation in Japanese Flounder (Paralichthys olivaceus)
Toshiya Yamaguchi, Takeshi Kitano
International Journal of Molecular Sciences 24(3) 2480-2480 2023年1月27日

・Inaba H, Iwata Y, Suzuki T, Horiuchi M, Surugaya R, Ijiri S, Uchiyama A, Takano R, Hara S, Yazawa T, Kitano T. Soy Isoflavones Induce Feminization of Japanese Eel (Anguilla japonica). International Journal of Molecular Sciences. 2022; 24: 396-396. 

・Hattori RS, Kumazawa K, Nakamoto M, Nakano Y, Yamaguchi T, Kitano T, Yamamoto E, Fuji K, Sakamoto T. Y-specific amh allele, amhy, is the master sex-determining gene in Japanese flounder Paralichthys olivaceus. Frontiers in Genetics 2022; 13: 1007548.

・Mukai K, Hara S, Sakima K, Nozu R, Yazawa T, Kitano T. Oxidative Stress Causes Masculinization of Genetically Female Medaka Without Elevating Cortisol. Frontiers in Endocrinology. 2022; 13: 878286.

・Kitano T, Takenaka T, Takagi H, Yoshiura Y, Kazeto Y, Hirai T, Mukai K, Nozu R. Roles of Gonadotropin Receptors in Sexual Development of Medaka. Cells. 2022;11:3.

・Inaba H, Hara S, Horiuchi M, Ijiri S, Kitano T., ”Gonadal expression profiles of sex-specific genes during early sexual differentiation in Japanese eel Anguilla japonica", Fisheries Science. 2021;87:203-209.

・Hara S, Sawamura R, Kitano T., ”Cortisol induces masculinization of XX medaka through gonadal soma-derived growth factor (GSDF) and anti-Müllerian hormone receptor type 2 (AMHR2)", Fisheries Science. 2021;87:85-91.

・Hara S, Furukawa F, Mukai K, Yazawa T, Kitano T., ”Peroxisome proliferator-activated receptor alpha is involved in the temperature-induced sex differentiation of a vertebrate", Scientific Reports. 2020;10:11672.

・Uchimura T, Hara S, Yazawa T, Kamei Y, Kitano T., ”Involvement of heat shock proteins on the transcriptional regulation of corticotropin-releasing hormone in medaka", Frontiers in Endocrinology. 2019;10:529.

・Sawamura R, Osafune N, Murakami T, Furukawa F, Kitano T., ”Generation of biallelic F0 mutants in medaka using the CRISPR/Cas9 system", Genes Cells. 2017;22(8):756-763.

・Murozumi N, Nakashima R, Hirai T, Kamei Y, Ishikawa-Fujiwara T, Todo T, Kitano T., "Loss of Follicle-Stimulating Hormone Receptor Function Causes Masculinization and Suppression of Ovarian Development in Genetically Female Medaka", Endocrinology. 2014;155(8):3136-3145.

・Hayashi Y, Kobira H, Yamaguchi T, Shiraishi E, Yazawa T, Hirai T, Kamei Y, Kitano T., "High temperature causes masculinization of genetically female medaka by elevation of cortisol", Mol. Reprod. Dev. 2010;77:679–686.

・ Kitano T., Yoshinaga N., Shiraishi E., Koyanagi T. and Abe S., "Tamoxifen induces masculinization of genetic females and regulates P450 aromatase and Mullerian inhibiting substance mRNA expression in Japanese flounder (Paralichthys olivaceus)", Molecular Reproduction and Development, 2007; 74:1171-1177.

・ Kitano T., Koyanagi T., Adachi R., Sakimura N., Takamune K. and Abe S., "Assessment of estrogenic chemicals using an estrogen receptor α (ERα)- and ERβ-mediated reporter gene assay in fish", Marine Biology, 149, 49-55, 2006.

・ Nakata H., Nasu T., Abe S., Kitano T., Fan Q., Li W. and Ding X., "Organochlorine contaminants in human adipose tissues from China: mass balance approach for estimating historical exposure to DDTs by Chinese", Environmental Science and Technology, 39, 4714-4720, 2005.

・ Nakata H., Hirakawa Y., Kawazoe M., Nakabo T., Arizono K., Abe S., Kitano T., Shimada H., Watanabe I., Li W. and Ding X., "Concentrations and compositions of organochlorine contaminants in sediments, soils, crustaceans, fishes and birds collected from lake Tai, Hangzhou bay and Shanghai city region, China", Environmental Pollution, 133, 415-429, 2005.

・ Shiraishi E., Imazato H., Yamamoto T., Yokoi H., Abe S. and Kitano T., "Identification of two teleost homologs of the Drosophila sex determination factor, transformer-2 in medaka (Oryzias latipes)", Mechanisms of Development, 121, 991-996, 2004.

・ Yoshinaga N., Shiraishi E., Yamamoto T., Iguchi T., Abe S. and Kitano T., "Sexually dimorphic expression of a teleost homologue of Mullerian inhibiting substance (MIS) during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus", Biochemical and Biophysical Research Communications, 322, 508-513, 2004.

・ Nagahama Y., Nakamura M., Kitano T. and Tokumoto T., "Sexual plasticity in fish: a possible target of endocrine disruptor action", Environmental Sciences, 11, 73-82, 2004.

・ Uchida D., Yamashita M., Kitano T. and Iguchi T., "An aromatase inhibitor or high water temperature induce oocyte apoptosis and deletion of P450 aromatase activity in the gonads of genetic female zebrafish during sex-reversal", Comparative Biochemistry and Physiology Part A, 137, 11-20, 2004.

・ Shimasaki Y., Kitano T., Oshima Y., Inoue S., Imada N. and Honjo T., "Tributyltin causes masculinization in fish", Environmental Toxicology and Chemistry, 22, 141-144, 2003.

・ Ohta K., Sundaray J.K., Okida T., Sakai M., Kitano T., Yamaguchi A., Takeda T., Matsuyama M., "Bi-directional sex change and its steroidogenesis in the wrasse, Pseudolabrus siebldi", Fish Physiology and Biochemistry, 28, 173-174, 2003.

・Yazawa T., Nakayama Y., Fujimoto K., Matsuda Y., Abe K., Kitano T., Abe S. and Yamamoto T., "Abnormal spermatogenesis at low temperatures in the Japanese red-bellied newt, Cynops pyrrhogaster: Possible biological significance of the cessation of spermatocytogenesis", Molecular Reproduction and Development, 66, 60-66, 2003.

・ Yamamoto T., Yazawa T., Fujimoto K., Kitano T. and Abe, S., "Low temperature promotes annexin v expression in newt testis", Zoological Science, 20, 733-735, 2003.

・ Kitano T., Takamune K., Nagahama Y. and Abe S.-I., "Gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus", Fisheries Science, 68, 679-680, 2002.

・ Nakata H., Kawazoe M., Arizono K., Abe S., Kitano T., Shimada H., Li W. and Ding X., "Organochlorine Pesticides and Polychlorinated Biphenyl Residues in Foodstuffs and Human Tissues from China: Status of Contamination, Historical Trend, and Human Dietary Exposure", Archives of Environmental Contamination and Toxicology, 43, 473-480, 2002.

・ Uchida D., Yamashita M., Kitano T. and Iguchi T., "Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish", Journal of Experimental Biology, 205, 711-718, 2002.

・ Shimasaki Y., Oshima Y., Yokota Y., Kitano T., Nakao M., Kawabata S., Imada N. and Honjo T., "Purification and identification of a tributyltin-binding protein from serum of Japanese flounder, Paralichthys olivaceus", Environmental Toxicology and Chemistry, 21, 1229-1235, 2002.

・ Fujimoto K., Yamamoto T., Kitano T. and Abe S.-I., "Promotion of cathepsin L activity in newt spermatogonial apoptosis induced by prolactin", FEBS Letters, 521, 43-46, 2002.

・ Kitano T., Takamune K., Nagahama Y. and Abe S.-I., "Role of P450 aromatase in gonadal sex differentiation in Japanese flounder (Paralichthys olivaceus)", Environmental Sciences, 8, 1-11, 2001.

・ Kitano T., Takamune K., Nagahama Y. and Abe S.-I., "Aromatase inhibitor and 17a-methyltestosterone cause sex-reversal from genetical females to phenotypic males and suppression of P450 aromatase gene expression in Japanese flounder (Paralichthys olivaceus)", Molecular Reproduction and Development, 56, 1-5, 2000.

・ 北野健、山本栄一、高宗和史、安部眞一, "アロマターゼmRNAの検出によるヒラメ人工種苗の早期性判別について", 日本水産学会誌, 66, 300-301, 2000

・ Kitano T., Takamune K., Kobayashi T., Nagahama Y. and Abe S.-I., "Suppression of P450 aromatase gene expression in sex-reversed males produced by rearing genetically female larvae at a high water temperature during a period of sex differentiation in the Japanese flounder (Paralichthys olivaceus)", Journal of Molecular Endocrinology, 23,167-176,1999

〔国際会議〕 　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　

・ Kitano T., Adachi R., Yoshinaga N. and Abe S., "Role of androgen in gonadal sex differentiation in Japanese flounder (Paralichthys olivaceus)", The 15th International Congress of Comparative Endocrinology (Boston, USA), 23-27 May 2005.

・ Shiraishi E., Yoshinaga N., Miura T., Wakamatsu Y., Ozato K., Abe S. and Kitano T., "Mullerian inhibiting substance is required for sexually dimorphic proliferation of germ cells during gonadal sex differentiation in medaka (Oryzias latipes)", The 15th International Congress of Comparative Endocrinology (Boston, USA), 23-27 May 2005.

・ Yang J., Adachi R., Yoshinaga N., Abe S. and Kitano T., "Effects of estrogen and estrogenic chemicals on gonadal sex differentiation in Japanese flounder (Paralichthys olivaceus)", The 15th International Congress of Comparative Endocrinology (Boston, USA), 23-27 May 2005.

・ Ohta K., Sundaray J.K., Kitano T., Shibata Y., Matsuda M., Yamaguchi A., Matsuyama M. and Nagahama Y., "Involvement of 17b-hydroxysteroid dehydrogenase in the sex change of a protogynous wrasse, Pseudolabrus sieboldi", The 15th International Congress of Comparative Endocrinology (Boston, USA), 23-27 May 2005.

・ Kitano T., Yoshinaga N., Adachi R. and Abe S., "Action of 11-ketotestosterone in gonadal sex differentiation in Japanese flounder (Paralichthys olivaceus)", 5th International Symposium of Fish Endocrinology (Castellon, Spain), 5-9 September 2004.

・ Kawakami Y., Kitano T., Adachi S., Yamauchi K. and Ohta H., "Transcriptional activity of conger eel thyroid hormone receptors with thyroid hormone", 5th International Symposium of Fish Endocrinology (Castellon, Spain), 5-9 September 2004.

・ Kitano T. (Invited), Koyanagi T. and Abe S.-I., "The mechanism of transcriptional regulation of vitellogenin gene in Japanese flounder (Paralichthys olivaceus)", Abstract of 7th International Symposium on Reproductive Physiology of Fish (Mie), P104, 2003.

・ Kitano T., Yamaguchi S. and Abe S.-I., "The mechanism of transcriptional regulation of P450 aromatase gene by two FTZ-F1 homologues in Japanese flounder (Paralichthys olivaceus)", Abstract of Third International Symposium on Vertebrate Sex Determination (Hawaii), P98-99, 2003.

・ Kitano T., Takamune K., Nagahama Y. and Abe S.-I., "Gonadal sex differentiation in Japanese flounder (Paralichthys olivaceus)", Abstracts of International Commemorative Symposium: 70th Anniversary of the Japanese Society of Fisheries Science (Yokohama), P110, 2001.

・ Kitano T., Takamune K., Nagahama Y. and Abe S.-I., "Role of estrogen in gonadal sex differentiation in Japanese flounder (Paralichthys olivaceus)", Proceedings of 14th International Congress of Comparative Endocrinology (Italy), P233-237, 2001.

・ Kitano T. (Invited), "Role of aromatase in gonadal sex differentiation in fish", Abstracts of Korea-Japan Endocrine Disrupters Symposium (Korea), P25-26, 2000.

・ Kitano T. (Invited), Takamune K., Nagahama Y. and Abe S.-I., "Role of aromatase in gonadal sex differentiation in Japanese flounder (Paralichthys olivaceus)", Abstracts of International Symposium on Endocrine-Disrupting Substance Testing in Medaka, P58, 2000

・ Kitano T., Yamamoto E., Tanaka M., Takamune K. and Abe S.-I., "Detection of cytochrome P450 aromatase mRNA by RT-PCR is an excellent method for sex distinction of early juveniles in Japanese flounder(Paralichthys olivaceus)", Abstracts of Fourth International Symposium on Flatfish Ecology, P36, 1999

・ Yamamoto E. and Kitano T., "Importance of the sex determining characteristics in flatfish study", Abstracts of Fourth International Symposium on Flatfish Ecology, P83, 1999

〔著書〕

・菊池潔・井尻茂保・北野健（編）2021．魚類の性決定・性分化・性転換 ーこれまでとこれから，恒星社厚生閣