Protein Aggregation
& Cell-to-cell Transmission
Neurodegenerative Diseases of Interest
Alzheimer's Disease (AD): Amyloid-β, Tau
Parkinson's Disease (PD): α-Synuclein
Dementia with Lewy Body (DLB): Amyloid-β, Tau, α-Synuclein
Amyotrophic Lateral Sclerosis (ALS): TDP43
Huntington's Disease (HD): mHTT
Protein aggregation and cell-to-cell transmission are key processes in the pathogenesis of neurodegenerative diseases. These diseases, such as Alzheimer's, Parkinson's, and Huntington's disease, are characterized by the abnormal accumulation of misfolded proteins in the brain. This protein aggregates not only affects the cell owning aggregates, but can be transmitted to other neighboring cell, propagating the disease throughout the brain.
Understanding the mechanisms of protein aggregation and cell-to-cell transmission is crucial for developing effective treatments for neurodegenerative diseases. This area of research continues to evolve, offering hope for new therapeutic strategies.