Publications
(equal contribution: *, corresponding authors: #)
2023
• Kang H, Park S, Jo A, Mao X, Kumar M, Park CH, Ahn JY, Lee Y, Choi JY, Lee YS, Dawson VL, Dawson TM, Kam TI#,
Shin JH#. "PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification" EMBO Rep.
2023 Nov 6;24(11):e56166.
• Bae JH*, Jo A*, Cho SC*, Lee YI*, Kam TI*, You CL, Jeong HJ, Kim H, Jeong MH, Jeong Y, Ha YW, Kim YS, Kim J,
Woo SH, Kim MS, Shin ES, Song SO, Kang H, Khang R, Park S, Park J, Dawson VL, Dawson TM#, Park SC#, Shin
JH#, Kang JS#. "Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of
Parkin-interacting substrate" Sci Transl Med 2023 Aug 30;15(711):eabh3489.
• Kam TI, Chen R, Dawson VL, Dawson TM. "Production of α-synuclein preformed fibrils (PFF)" Protocols.io 2023
• Kim SH, Cho YS, Kim Y, Park J, Yoo SM, Gwak J, Kim Y, Gwon Y, Kam TI, Jung YK. "Endolysosomal impairment
Autophagy 2023 Feb 26;1-20.
• Kim Y, Park H, Kim Y, Kim SH, Lee JH, Yang H, Kim SJ, Li CM, Lee H, Na DH, Moon S, Shin Y, Kam TI, Lee HW,
Kim S, Song JJ, Jung YK. "Pathogenic Role of RAGE in Tau Transmission and Memory Deficits" Biol Psychiatry
2023 May 1;93(9):829-841.
2022
• Chun YS, Kim MY, Lee SY, Kim MJ, Hong TJ, Jeon JK, Ganbat D, Kim HT, Kim SS, Kam TI # , Han S#. "MEK1/2
Alzheimer's Disease" Mol Psychiatry 2022 Nov;27(11):4770-4780.
• Park H*, Kam TI*, Peng H, Chou SC, Mehrabani-Tabar AA, Song JJ, Yin X, Karuppagounder SS, Umanah GK, Rao
Choi Y, Aggarwal A, Chang S, Kim H, Byun J, Liu JO, Dawson TM, Dawson VL. "PAAN/MIF Nuclease Inhibition
Prevents Neurodegeneration in Parkinson’s Disease" Cell 2022 May 26;185(11):1943-1959.e21.
• Kam TI, Park H, Chou SC, Vranken JGV, Mittenbühler MJ, Kim H, A M, Choi YR, Biswas D, Wang J, Shin Y, Loder
A, Karuppagounder SS, Wrann CD, Dawson VL, Spiegelman BM, Dawson TM. "Amelioration of pathologic
α-synuclein-induced Parkinson’s disease by irisin" Proc Natl Acad Sci USA 2022 Sep 6;119(36):e2204835119.
• Sterling JK*, Kam TI*, Guttha S, Park H, Baumann B, Mehrabani-Tabari AA, Schultz H, Anderson B, Alnemri A,
Chou SC, Troncoso JC, Dawson VL, Dawson TM, Dunaief J. "Interleukin-6 triggers toxic neuronal iron
sequestration in response to pathological α-synuclein" Cell Rep 2022 Feb 15;38(7):110358.
• Panicker N, Kam TI, Wang H, Neifert S, Chou SC, Kumar M, Brahmachari S, Jhaldiyal A, Hinkle JT, Akkentli F, Mao
X, Xu E, Karuppagounder SS, Hsu ET, Kang SU, Pletnikova O, Troncoso J, Dawson VL, Dawson TM. "Neuronal
NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease" Neuron 2022 Aug 3;110(15):
2422-2437.e9.
• Gao J, Mewborne QT, Girdhar A, Sheth U, Coyne AN, Punathil R, Kang BG, Dasovich M, Veire A, DeJesus
Hernandez M, Liu S, Shi Z, Dafinca R, Fouquerel E, Talbot K, Kam TI, Zhang YJ, Dickson D, Petrucelli L, van
Blitterswijk M, Guo L, Dawson TM, Dawson VL, Leung AKL, Lloyd TE, Gendron TF, Rothstein JD, Zhang K.
"Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins" Sci Transl Med 2022
Sep 14;14(662):eabq3215.
2021
• Chou SC, Aggarwal A, Dawson VL, Dawson TM#, Kam TI #. "Recent advances in preventing neurodegenerative
diseases" Fac Rev 2021 Dec 1;10:81.
• Jo A*, Lee Y*, Kam TI*, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jian
H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS, Kang HC, Lee BD, Lee YI, Andrabi SA,
Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH.
"PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease" Sci Transl Med 2021 Jul 28;
13(604):eaax8891.
• Park JS*, Kam TI*, Lee S, Park H, Oh Y, Kwon SH, Song JJ, Kim D, Kim H, Jhaldiyal A, Na DH, Lee KC, Park EJ,
Pomper MG, Pletnikova O, Troncoso JC, Ko HS, Dawson VL, Dawson TM, Lee S. "Blocking microglial activation of
reactive astrocytes is neuroprotective in models of Alzheimer's disease" Acta Neuropathol Commun 2021 Apr
26;9(1):78.
• Seo BA, Kim D, Hwang H, Kim MS, Ma SX, Kwon SH, Kweon SH, Wang H, Yoo JM, Choi S, Kwon SH, Kang SU,
Kam TI, Kim K, Karuppagounder SS, Kang BG, Lee S, Park H, Kim S, Yan W, Li YS, Kuo SH, Redding-Ochoa J,
Pletnikova O, Troncoso JC, Lee G, Mao X, Dawson VL, Dawson TM, Ko HS. "TRIP12 ubiquitination of
glucocerebrosidase contributes to neurodegeneration in Parkinson's disease" Neuron 2021 Dec 1;109(23):
3758-3774.e11.
• Zhang L, Chen C, Fu J, Lilley B, Berlinicke C, Hansen B, Ding D, Wang G, Wang T, Shou D, Ye Y, Mulligan T,
Emmerich K, Saxena MT, Hall KR, Sharrock AV, Brandon C, Park H, Kam TI, Dawson VL, Dawson TM, Shim JS,
Hanes J, Ji H, Liu JO, Qian J, Ackerley DF, Rohrer B, Zack DJ, Mumm JS. "Large-scale phenotypic drug screen
identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa" Elife 2021 Jun 29;10:e57245.
• Ma SX, Seo BA, Kim D, Xiong Y, Kwon SH, Brahmachari S, Kim S, Kam TI, Nirujogi RS, Kwon SH, Dawson VL,
Dawson TM, Pandey A, Na CH, Ko HS. "Complement and coagulation cascades are potentially involved in
dopaminergic neurodegeneration in α-synuclein-based mouse models of Parkinson's disease" J Proteome Res
2021 Jul 2;20(7):3428-3443.
2020
• Kam TI, Hinkle JT, Dawson TM, Dawson VL. "Microglia and astrocyte dysfunction in Parkinson's disease"
Neurobiol Dis 2020 Oct;144:105028.
• Park H, Kam TI, Dawson TM, Dawson VL. "Poly (ADP-ribose) (PAR)-dependent cell death in neuro-degenerative
diseases" Int Rev Cell Mol Biol 2020;353:1-29.
2019
• Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C,
Lee H, Kulkarni S, Pasricha PJ, Lee G, Pomper MG, Dawson VL, Dawson TM, Ko HS. "Transneuronal propagation
of pathologic α-synuclein from the gut to the brain models Parkinson's disease" Neuron 2019 Aug 21;103(4):627-
641.e7.
• Jin J, Smith MD, Kersbergen CJ, Kam TI, Viswanathan M, Martin K, Dawson TM, Dawson VL, Zack DJ, Whartenby
K, Calabresi PA. "Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental
autoimmune encephalomyelitis" Acta Neuropathol Commun 2019 Jul 31;7(1):125.
• Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M,
Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A.
"Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia" J Exp Med
2019 Jun 3;216(6):1411-1430.
• Brahmachari S, Lee S, Kim S, Yuan C, Karuppagounder SS, Ge P, Shi R, Kim EJ, Liu A, Kim D, Quintin S, Jiang H,
Kumar M, Yun SP, Kam TI, Mao X, Lee Y, Swing DA, Tessarollo L, Ko HS, Dawson VL, Dawson TM.
2019 Aug 1;142(8):2380-2401.
• Gwon Y, Kim SH, Kim HT, Kam TI, Park J, Lim B, Cha H, Chang HJ, Hong YR, Jung YK. "Amelioration of amyloid
β-FcγRIIb neurotoxicity and tau pathologies by targeting LYN" FASEB J 2019 Mar;33(3):4300-4313.
2018
• Kam TI*, Mao X*, Park H*, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmarchari S, Panicker N,
Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS,
Rosenthal LS, Dawson TM, Dawson VL. "Poly (ADP-ribose) drives pathologic a-synuclein neurodegeneration in
Parkinson’s disease" Science 2018 Nov 2;362(6414):eaat8407.
• Yun SP*, Kam TI*, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh
N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee
SH, Roschke V, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS. "Block of A1 astrocyte
conversion by microglia is neuroprotective in models of Parkinson’s disease" Nat Med 2018 Jul;24(7):931-938.
• Gwon Y*, Kam TI*, Kim SH, Song S, Park H, Lim B, Lee H, Lee W, Jo DG, Jung YK. "TOM1 regulates neuronal
accumulation of amyloid-β oligomers by FcγRIIb2 variant in Alzheimer’s disease" J Neurosci 2018 Oct 17;38(42):
9001-9018.
• Yun SP, Kim D, Kim S, Kim S, Karuppagounder SS, Kwon SH, Lee S, Kam TI, Lee S, Ham S, Park JH, Dawson
VL, Dawson TM, Lee Y, Ko HS. "α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation
contributes to MPTP-induced parkinsonism" Mol Neurodegener 2018 Jan 8;13(1):1.
2017
• Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K,
Brahmachari S, Kim JW, Neifert S, Yun SP, Fiesel FC, Springer W, Dawson VL, Shin JH, Dawson TM. "PINK1
primes Parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival" Cell Rep 2017 Jan 24;18(4):
918-932.
2016
• Kam TI*, Park H*, Gwon Y*, Song S, Kim SH, Moon SW, Jo DG, Jung YK. "FcγRIIb-SHIP2 axis links Aβ to tau
pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model" Elife 2016 Nov 11;5:e18691.
• Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang
JE, Kam TI, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL,
Dawson TM. "A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1"
Science 2016 Oct 7;354(6308):aad6872.
• Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang
HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler
JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. "Pathological
α-synuclein transmission initiated by binding lymphocyte-activation gene 3" Science 2016 Sep 30;353(6307):
aah3374.
• Xu JC, Fan J, Wang X, Eacker SM, Kam TI, Chen L, Yin X, Zhu J, Chi Z, Jiang H, Chen R, Dawson TM, Dawson
neurotoxicity" Sci Transl Med 2016 Apr 6;8(333):333ra48.
• Kim Y, Choi H, Lee W, Park H, Kam TI, Hong SH, Nah J, Jung S, Shin B, Lee H, Choi TY, Choo H, Kim KK, Choi
SY, Kayed R, Jung YK. "Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a
transgenic mouse model" Neurobiol Dis 2016 Mar;87:19-28.
2015
• Choi S, Kim D, Kam TI, Yun S, Kim S, Park H, Hwang H, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko
HS. "Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity" PLoS One
2015 Dec 2;10(12):e0143854.
• Kim Y, Park H, Nah J, Moon S, Lee W, Hong SH, Kam TI, Jung YK. "Essential role of POLDIP2 in Tau aggregation
and neurotoxicity via autophagy/proteasome inhibition" Biochem Biophys Res Commun 2015 Jun 26;462(2):112.
2014
• Kam TI, Gwon Y, Jung YK. "Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's
disease" Cell Mol Life Sci 2014 Dec;71(24):4803-13.
• Han J, Jung S, Jang J, Kam TI, Choi H, Kim BJ, Nah J, Jo DG, Nakagawa T, Nishimura M, Jung YK. "OCIAD2
activates γ-secretase to enhance amyloid β production by interacting with nicastrin" Cell Mol Life Sci 2014
Jul;71(13):2561-76.
2013
• Kam TI*, Song S*, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS,
Choi SY, Choi S, Klein WL, Yuan J, and Jung YK. "FcγRIIb mediates amyloid-β neurotoxicity and memory
impairment in Alzheimer’s disease" J Clin Invest 2013 Jul;123(7):2791-802.
2012
• Park H, Kam TI, Kim Y, Choi H, Gwon Y, Kim C, Koh JY, and Jung YK. "Neuropathogenic role of adenylate kinase 1
in Aβ-mediated tau phosphorylation via AMPK and GSK3β" Hum Mol Genet 2012 Jun 15;21(12):2725-37.
2008
• Song S, Lee H, Kam TI, Tai ML, Lee JY, Noh JY, Shim SM, Seo SJ, Kong YY, Nakagawa T, Chung CW, Choi DY,
Oubrahim H, Jung YK. "E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity" J Cell Biol
2008 Aug 25;182(4):675-84.