Publications

(equal contribution: *, corresponding authors: #)

2025

• Ryu T, Kim SY, Thuraisamy T, Shin J, Jang Y, Kam TI, Na CH. "In-Depth Cell-Type-Specific Proteome Landscape of the Brain from Human Amyloid-β Overexpression Mouse Model" Advanced Science. 2025 May;12(20):e2409318.

• Mills KA, Du Y, Coughlin JM, Foss CA, Horti AG, Jenkins KR, Skorobogatova Y, Spiro E, Motley CS, Dannals RF, Lesniak WG, Song JJ, Choi YR, Redding-Ochoa J, Troncoso JC, Dawson VL, Kam TI, Pomper MG, Dawson TM. "Exploring [11C]CPPC as a CSF1R-targeted PET imaging marker for early Parkinson's disease severity" J Clin Invest. 2025 Apr 15;135(12):e186591.

2024

• Park H, Kam TI*, Dawson VL, Dawson TM. "α-Synuclein pathology as a target in neurodegenerative diseases" Nature Reviews Neurology, 2024, 1-16.  

• Maiuri T, Bazan CB, Harding RJ, Begeja N, Kam TI, Byrne LM, Rodrigues FB, Warner MM, Neuman K, Mansoor M, Badiee M, Dasovich M, Wang K, Thompson LM, Leung AKL, Andres SN, Wild EJ, Dawson TM, Dawson VL, Arrowsmith CH, Truant R. "Poly ADP-ribose signaling is dysregulated in Huntington disease" Proc Natl Acad Sci USA. 2024 Oct;121(40):e2318098121. 

• Sul JH, Shin S, Kim HK, Han J, Kim J, Son S, Lee J, Baek SH, Cho Y, Lee J, Park J, Ahn D, Park S, Palomera LF, Lim J, Kim J, Kim C, Han S, Chung KY, Lee S, Kam TI, Lee Y, Kim J, Park JH, Jo DG. "Dopamine-conjugated extracellular vesicles induce autophagy in Parkinson's disease" J Extracell Vesicles. 2024 Dec;13(12):e70018.

2023

• Kang H, Park S, Jo A, Mao X, Kumar M, Park CH, Ahn JY, Lee Y, Choi JY, Lee YS, Dawson VL, Dawson TM, Kam TI#, Shin JH#. "PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification" EMBO Rep. 2023 Nov 6;24(11):e56166. 

• Bae JH*, Jo A*, Cho SC*, Lee YI*, Kam TI*, You CL, Jeong HJ, Kim H, Jeong MH, Jeong Y, Ha YW, Kim YS, Kim J, Woo SH, Kim MS, Shin ES, Song SO, Kang H, Khang R, Park S, Park J, Dawson VL, Dawson TM#, Park SC#, Shin JH#, Kang JS#. "Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate"  Sci Transl Med  2023 Aug 30;15(711):eabh3489.

• Kam TI, Chen R, Dawson VL, Dawson TM. "Production of α-synuclein preformed fibrils (PFF)" Protocols.io  2023 

• Kim SH, Cho YS, Kim Y, Park J, Yoo SM, Gwak J, Kim Y, Gwon Y, Kam TI, Jung YK. "Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease" Autophagy  2023 Feb 26;1-20.

• Kim Y, Park H, Kim Y, Kim SH, Lee JH, Yang H, Kim SJ, Li CM, Lee H, Na DH, Moon S, Shin Y, Kam TI,  Lee HW, Kim S, Song JJ, Jung YK. "Pathogenic Role of RAGE in Tau Transmission and Memory Deficits"  Biol Psychiatry  2023 May 1;93(9):829-841.

2022

• Chun YS, Kim MY, Lee SY, Kim MJ, Hong TJ, Jeon JK, Ganbat D, Kim HT, Kim SS, Kam TI # , Han S#. "MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer's Disease"  Mol Psychiatry  2022 Nov;27(11):4770-4780.

• Park H*, Kam TI*, Peng H, Chou SC, Mehrabani-Tabar AA, Song JJ, Yin X, Karuppagounder SS, Umanah GK, Rao Choi Y, Aggarwal A, Chang S, Kim H, Byun J, Liu JO, Dawson TM, Dawson VL. "PAAN/MIF Nuclease Inhibition Prevents Neurodegeneration in Parkinson’s Disease"  Cell  2022 May 26;185(11):1943-1959.e21.

• Kam TI, Park H, Chou SC, Vranken JGV, Mittenbühler MJ, Kim H, A M, Choi YR, Biswas D, Wang J, Shin Y, Loder A, Karuppagounder SS, Wrann CD, Dawson VL, Spiegelman BM, Dawson TM. "Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin"  Proc Natl Acad Sci USA  2022 Sep 6;119(36):e2204835119.

• Sterling JK*, Kam TI*, Guttha S, Park H,  Baumann B, Mehrabani-Tabari AA, Schultz H, Anderson B, Alnemri A, Chou SC, Troncoso JC, Dawson VL, Dawson TM, Dunaief J. "Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein"  Cell Rep  2022 Feb 15;38(7):110358.

• Panicker N, Kam TI, Wang H, Neifert S, Chou SC, Kumar M, Brahmachari S, Jhaldiyal A, Hinkle JT, Akkentli F, Mao X, Xu E, Karuppagounder SS, Hsu ET, Kang SU, Pletnikova O, Troncoso J, Dawson VL, Dawson TM. "Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease"  Neuron  2022 Aug 3;110(15): 2422-2437.e9.

• Gao J, Mewborne QT, Girdhar A, Sheth U, Coyne AN, Punathil R, Kang BG, Dasovich M, Veire A, DeJesus Hernandez M, Liu S, Shi Z, Dafinca R, Fouquerel E, Talbot K, Kam TI, Zhang YJ, Dickson D, Petrucelli L, van Blitterswijk M, Guo L, Dawson TM, Dawson VL, Leung AKL, Lloyd TE, Gendron TF, Rothstein JD, Zhang K. "Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins"  Sci Transl Med  2022 Sep 14;14(662):eabq3215.

2021

• Chou SC, Aggarwal A, Dawson VL, Dawson TM#, Kam TI #. "Recent advances in preventing neurodegenerative diseases"  Fac Rev  2021 Dec 1;10:81. 

• Jo A*, Lee Y*, Kam TI*, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jian H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS, Kang HC, Lee BD, Lee YI, Andrabi SA, Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH. "PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease"  Sci Transl Med  2021 Jul 28; 13(604):eaax8891.

• Park JS*, Kam TI*, Lee S, Park H, Oh Y, Kwon SH, Song JJ, Kim D, Kim H, Jhaldiyal A, Na DH, Lee KC, Park EJ, Pomper MG, Pletnikova O, Troncoso JC, Ko HS, Dawson VL, Dawson TM, Lee S. "Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease"  Acta Neuropathol Commun  2021 Apr 26;9(1):78. 

• Seo BA, Kim D, Hwang H, Kim MS, Ma SX, Kwon SH, Kweon SH, Wang H, Yoo JM, Choi S, Kwon SH, Kang SU, Kam TI, Kim K, Karuppagounder SS, Kang BG, Lee S, Park H, Kim S, Yan W, Li YS, Kuo SH, Redding-Ochoa J, Pletnikova O, Troncoso JC, Lee G, Mao X, Dawson VL, Dawson TM, Ko HS. "TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease"  Neuron  2021 Dec 1;109(23): 3758-3774.e11. 

• Zhang L, Chen C, Fu J, Lilley B, Berlinicke C, Hansen B, Ding D, Wang G, Wang T, Shou D, Ye Y, Mulligan T, Emmerich K, Saxena MT, Hall KR, Sharrock AV, Brandon C, Park H, Kam TI, Dawson VL, Dawson TM, Shim JS, Hanes J, Ji H, Liu JO, Qian J, Ackerley DF, Rohrer B, Zack DJ, Mumm JS. "Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa"  Elife  2021 Jun 29;10:e57245.

• Ma SX, Seo BA, Kim D, Xiong Y, Kwon SH, Brahmachari S, Kim S, Kam TI, Nirujogi RS, Kwon SH, Dawson VL, Dawson TM, Pandey A, Na CH, Ko HS. "Complement and coagulation cascades are potentially involved in dopaminergic neurodegeneration in α-synuclein-based mouse models of Parkinson's disease"  J Proteome Res  2021 Jul 2;20(7):3428-3443.

2020

• Kam TI, Hinkle JT, Dawson TM, Dawson VL. "Microglia and astrocyte dysfunction in Parkinson's disease"  Neurobiol Dis  2020 Oct;144:105028.

• Park H, Kam TI, Dawson TM, Dawson VL. "Poly (ADP-ribose) (PAR)-dependent cell death in neuro-degenerative diseases"  Int Rev Cell Mol Biol  2020;353:1-29.

2019

• Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C, Lee H, Kulkarni S, Pasricha PJ, Lee G, Pomper MG, Dawson VL, Dawson TM, Ko HS. "Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson's disease"  Neuron  2019 Aug 21;103(4):627-641.e7. 

• Jin J, Smith MD, Kersbergen CJ, Kam TI, Viswanathan M, Martin K, Dawson TM, Dawson VL, Zack DJ, Whartenby K, Calabresi PA. "Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis"  Acta Neuropathol Commun  2019 Jul 31;7(1):125.

• Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A.  "Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia" J Exp Med  2019 Jun 3;216(6):1411-1430.

• Brahmachari S, Lee S, Kim S, Yuan C, Karuppagounder SS, Ge P, Shi R, Kim EJ, Liu A, Kim D, Quintin S, Jiang H, Kumar M, Yun SP, Kam TI, Mao X, Lee Y, Swing DA, Tessarollo L, Ko HS, Dawson VL, Dawson TM. "Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease"  Brain  2019 Aug 1;142(8):2380-2401.

• Gwon Y, Kim SH, Kim HT, Kam TI, Park J, Lim B, Cha H, Chang HJ, Hong YR, Jung YK. "Amelioration of amyloid β-FcγRIIb neurotoxicity and tau pathologies by targeting LYN"  FASEB J  2019 Mar;33(3):4300-4313.

2018

• Kam TI*, Mao X*, Park H*, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmarchari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL. "Poly (ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease"  Science  2018 Nov 2;362(6414):eaat8407.

• Yun SP*, Kam TI*, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke V, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS. "Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease"  Nat Med  2018 Jul;24(7):931-938.

• Gwon Y*, Kam TI*, Kim SH, Song S, Park H, Lim B, Lee H, Lee W, Jo DG, Jung YK. "TOM1 regulates neuronal accumulation of amyloid-β oligomers by FcγRIIb2 variant in Alzheimer’s disease"  J Neurosci  2018 Oct 17;38(42):9001-9018.

• Yun SP, Kim D, Kim S, Kim S, Karuppagounder SS, Kwon SH, Lee S, Kam TI, Lee S, Ham S, Park JH, Dawson VL, Dawson TM, Lee Y, Ko HS. "α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism"  Mol Neurodegener  2018 Jan 8;13(1):1.

2017

• Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K, Brahmachari S, Kim JW, Neifert S, Yun SP, Fiesel FC, Springer W, Dawson VL, Shin JH, Dawson TM. "PINK1 primes Parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival"  Cell Rep  2017 Jan 24;18(4):918-932. 

2016

• Kam TI*, Park H*, Gwon Y*, Song S, Kim SH, Moon SW, Jo DG, Jung YK. "FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model"  Elife  2016 Nov 11;5:e18691.

• Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL, Dawson TM. "A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1"  Science  2016 Oct 7;354(6308):aad6872.

• Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J,  Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. "Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3"  Science  2016 Sep 30;353(6307): aah3374.

• Xu JC, Fan J, Wang X, Eacker SM, Kam TI, Chen L, Yin X, Zhu J, Chi Z, Jiang H, Chen R, Dawson TM, Dawson VL. "Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity"  Sci Transl Med  2016 Apr 6;8(333):333ra48. 

• Kim Y, Choi H, Lee W, Park H, Kam TI, Hong SH, Nah J, Jung S, Shin B, Lee H, Choi TY, Choo H, Kim KK, Choi SY, Kayed R, Jung YK. "Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model"  Neurobiol Dis  2016 Mar;87:19-28. 

2015

• Choi S, Kim D, Kam TI, Yun S, Kim S, Park H, Hwang H, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS. "Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity" PLoS One 2015 Dec 2;10(12):e0143854. 

• Kim Y, Park H, Nah J, Moon S, Lee W, Hong SH, Kam TI, Jung YK. "Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition" Biochem Biophys Res Commun  2015 Jun 26;462(2):112.

2014

• Kam TI, Gwon Y, Jung YK. "Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease"  Cell Mol Life Sci  2014 Dec;71(24):4803-13.

• Han J, Jung S, Jang J, Kam TI, Choi H, Kim BJ, Nah J, Jo DG, Nakagawa T, Nishimura M, Jung YK. "OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin"  Cell Mol Life Sci  2014 Jul;71(13):2561-76.

2013

• Kam TI*, Song S*, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, Klein WL, Yuan J, and Jung YK. "FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease"  J Clin Invest  2013 Jul;123(7):2791-802. 

2012

• Park H, Kam TI, Kim Y, Choi H, Gwon Y, Kim C, Koh JY, and Jung YK. "Neuropathogenic role of adenylate kinase 1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β"  Hum Mol Genet  2012 Jun 15;21(12):2725-37.

2008

• Song S, Lee H, Kam TI, Tai ML, Lee JY, Noh JY, Shim SM, Seo SJ, Kong YY, Nakagawa T, Chung CW, Choi DY, Oubrahim H, Jung YK. "E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity" J Cell Biol 2008 Aug 25;182(4):675-84.