Neurodegeneration
& Neuroinflammation
Molecular Mechanisms of Neuron-Glia Interactions
Neuronal cell death
Microglia
Astrocytes
Oligodendrocytes
Oligodendrocyte Precursor Cells
The molecular mechanisms of neuron-glia interactions play a crucial role in the progression of neurodegenerative diseases. Neurons and glial cells, including astrocytes, microglia, and oligodendrocytes, interact closely within the nervous system. In a healthy brain, these interactions are essential for maintaining homeostasis, supporting neural function, and facilitating brain repair. However, in neurodegenerative diseases, these interactions become dysregulated, contributing to disease progression.
Understanding these complex neuron-glia interactions is vital for unraveling the pathophysiology of neurodegenerative diseases. It offers potential therapeutic targets aimed at restoring the balance in these interactions, thereby offering hope for new treatments that could slow or prevent the progression of these debilitating diseases.