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We are studying
BRain and Integrated Neurodegenerative Diseases (BRaIN)
The mission of the BRain and Integrated Neurodegenerative diseases (BRaIN) laboratory is to promote and conduct multidisciplinary basic and translational research to increase the understanding of the causes and mechanisms leading to brain dysfunction and degeneration in neurodegenerative diseases.
뇌-신경질환 (BRaIN) 연구실은 퇴행성 뇌질환의 이해라는 큰 목표를 가지고 연구를 하는 연구실입니다. 다양한 퇴행성 뇌질환의 원인과 분자 수준의 메커니즘을 다학제적 기초 및 중개 연구를 통해 다양하고 상세하게 밝히고자 합니다.
이러한 연구를 통해 퇴행성 뇌질환을 치료하거나 예방하는 더 효과적인 접근법을 발견하고, 퇴행성 뇌질환의 위험을 줄여 건강한 노화를 제공하는 것을 목표로 합니다.
Research Topics
Protein Aggregation
& cell-to-cell Transmision
Neurodegeneration
& Neuroinflammation
Therapeutic Approach
& Drug Development
Highlights
Kang H, Park S, Jo A, Mao X, Kumar M, Park CH, Ahn JY, Lee Y, Choi JY, Lee YS, Dawson VL, Dawson TM, Kam TI#, Shin JH#. "PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification" EMBO Rep. 2023 Nov 6;24(11):e56166.
Chun YS, Kim MY, Lee SY, Kim MJ, Hong TJ, Jeon JK, Ganbat D, Kim HT, Kim SS, Kam TI # , Han S#. "MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer's Disease" Mol Psychiatry 2022 Nov;27(11):4770-4780.
Park H*, Kam TI*, Peng H, Chou SC, Mehrabani-Tabar AA, Song JJ, Yin X, Karuppagounder SS, Umanah GK, Rao Choi Y, Aggarwal A, Chang S, Kim H, Byun J, Liu JO, Dawson TM, Dawson VL. "PAAN/MIF Nuclease Inhibition Prevents Neurodegeneration in Parkinson’s Disease" Cell 2022 May 26;185(11):1943-1959.e21.
Kam TI, Park H, Chou SC, Vranken JGV, Mittenbühler MJ, Kim H, A M, Choi YR, Biswas D, Wang J, Shin Y, Loder A, Karuppagounder SS, Wrann CD, Dawson VL, Spiegelman BM, Dawson TM. "Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin" Proc Natl Acad Sci USA 2022 Sep 6;119(36):e2204835119.
Jo A*, Lee Y*, Kam TI*, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jian H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS, Kang HC, Lee BD, Lee YI, Andrabi SA, Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH. "PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease" Science Translational Medicine 2021 Jul 28;13(604):eaax8891.
Kam TI*, Mao X*, Park H*, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmarchari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL. "Poly (ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease" Science 2018 Nov 2;362(6414):eaat8407.
Yun SP*, Kam TI*, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke V, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS. "Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease" Nature Medicine 2018 Jul;24(7):931-938
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