Systems Immunology & Translational Medicine Lab
系統免疫暨轉譯醫學實驗室
Publications
Articles
YC Fan, YC Fong, CT Kuo, CW Li, WY Chen, JD Lin, F Burtin, M Linnebacher, QT Bui, KD Lee, YC Tsai. Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer. Cell and Bioscience, 13(147), August, 2023. (Rank: Q1, BIOCHEMISTRY & MOLECULAR BIOLOGY , 5-yr. IF=7.9).
D G Loredan, J C Devlin, K A Lacey, N Howard, Z Chen, E E Zwack, JD Lin, K V Ruggles, K M Khanna, V J Torres, P Loke*. Single-cell analysis of CX3CR1+ cells reveals a pathogenic role for BIRC5+ myeloid proliferating cells driven by Staphylococcus aureus leukotoxins. Journal of Immunology, 211, July 2023. (Rank: Q2, IMMUNOLOGY, 5-yr. IF=5.2; Citations≥1).
SY Chen, CT Chu, ML Yang, JD Lin, CT Wang, CH Lee, IC Lin, AL Shiau, P Ling, CL Wu. Amelioration of murine colitis by attenuated Salmonella choleraesuis encoding interleukin-19. microorganisms, 11(6), June 2023. (Rank: Q2, MICROBIOLOGY, 5-yr. IF=4.8; Citations≥1).
YH Chen*, F Yeung*, KA Lacey, K Zaldana, JD Lin#, GCW Bee, C McCauley, RS Barre, SH Liang, CB Hansen, AE Downie, K Tio, JN Weiser, VJ Torres, RJ Bennett, P Loke, AL Graham, K Cadwell. Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization. Science Immunology, 8(84), June 2023. (Rank: Q1, IMMUNOLOGY, 5-yr. IF=22, Citations≥8), *Co-first Author, #4th Author.
P Loke*, JD Lin*. Redefining inflammatory macrophage phenotypes across stages and tissues by single-cell transcriptomics. Science Immunology, 7(70), April 2022. (Rank: Q1, IMMUNOLOGY, 5-yr. IF=22, Citations≥11), *Corresponding Author.
JD Lin*, P Loke*. Helminth infections and cardiovascular diseases: A role for the microbiota and Møs? Journal of Leukocyte Biology, 110(6), September 2021. (Rank: Q2, HEMOTOLOGY, 5-yr. IF=5.4, Citations≥4), *Corresponding Author.
C McElrath, V Espinosa, JD Lin#, J Peng, R Sridhar, O Dutta, HC Tseng, S V Smirnov, H Risman, M J Sandoval, V Davra, YJ Chang, B P Pollack, R B Birge, M Galan, A Rivera, J E Durbin, S V Kotenko. Critical role of interferons in gastrointestinal injury repair. Nature Communication, 12(1), May 2021. (Rank: Q1, MULTIDISPLINARY SCIENCES, 5-yr. IF=17, Citations≥51), #3rd Author.
J C Devlin*, J Axelrad*, A M Hine*, S Chang, S Sarkar, JD Lin#, K V Ruggles, D Hudesman, K Cadwell, P Loke. Single-cell transcriptional survey of ileal-anal pouch immune cells from ulcerative colitis patients. Gastroenterology, 160(5), April 2021. (Rank: Q1, GASTROENTEROLOGY & HEPATOLOGY, 5-yr. IF=25.8, Citations≥38), *Co-first Author. #4th Author.
JD Lin, J C Devlin, F Yeung, C McCauley, J M. Leung, YH Chen, A Cronkite, C Hansen, C Drake-Dunn, K V. Ruggles, K Cadwell, A L Graham, P Loke. Rewilding Nod2 and Atg16l1 mutant mice uncover genetic and environmental contributions towards variation in microbial responses and immune cell composition. Cell Host & Microbe, 27(5), May 2020. (Rank: Q1, MICROBIOLOGY, 5-yr. IF=25.7, Citations≥64)
F Yeung*, YH Chen*, JD Lin*, J M Leung, C McCauley, J C. Devlin, C Hansen, A Cronkite, Z Stephens, C Drake-Dunn, Y Fulmer, B Shopsin, K V. Ruggles, J L. Round, P Loke, A L Graham, K Cadwell. Altered immunity of laboratory mice in the natural environment is associated with fungal colonization. Cell Host & Microbe, 27(5), May, 2020. (Rank: Q1, MICROBIOLOGY, 5-yr. IF=25.7, Citations≥116); *Co-first Author.
JD Lin, H Nishi, J Poles, X Niu, C Mccauley, K Rahman, E J. Brown, S T Yeung, N Vozhilla, A Weinstock, S Ramsey, E A Fisher and P Loke. Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression. JCI insight, 4 (4), February, 2019. (Rank: Q1, MEDICINE, RESEARCH & EXPERIMENTAL, 5-yr. IF=8.6; Citations≥269) (Top 1% cited in "Clinical Medicine" field)
U M Gundra, N M Girgis, M A Gonzalez, MS Tang, H J P Van Der Zande, JD Lin, M Ouimet, L J Ma, J Poles, N Vozhilla, E A Fisher, K J Moore, P Loke. Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation. Nature Immunology, 18 (6), June 2017. (Rank: Q1, IMMUNOLOGY, 5-yr. IF=29.6; Citations≥142)
JD Lin, N Feng, A Sen, M Balan, HC Tseng, C McElrath, S V Smirnov, J Peng, L L Yasukawa, R K. Durbin, J E Durbin, H B Greenberg and S V. Kotenko. Distinct roles of type I and type III interferons in intestinal immunity to homologous and heterologous rotavirus infection. PLoS Pathog., 12 (4), April, 2016. (Rank: Q1, MICROBIOLOGY, 5-yr. IF=6.7; Citations≥176)
Conference Issues
JD Lin, TY Chou, YZ Ye, IJ Lin, CJ Lien, ZY Wang, CH Yang, PA Chao, YT Chen, P Loke. Single-cell multi-omics analysis reveals serum amyloid A3 restrains alternative activations in macrophages derived from different origins. Journal of Immunology, 210 (1 Supplement), May 2023.
JD Lin, TY Chou, CH Yang, PA Chao, YT Chen, P Loke. Single-cell multi-omic analysis identifies heterogeneity and distinct features in fate-mapped tissue-resident alternatively activated macrophages. Journal of Immunology, 210 (1 Supplement), May 2022.
Jian-Da Lin, Frank Yeung, Cooper Devlin, Ying-Han Chen, Caroline McCauley, Alex Cronkite, Jacqueline M. Leung, Andrea L. Graham, Ken H. Cadwell, P’ng Loke. Integration of multi-omics data from re-wilded laboratory mice to identify key parameters that determine immune heterogeneity and activation. J. Immunol., 202 (1 Supplement), May, 2019.
Jian-Da Lin, Hitoo Nishi, Jordan Poles, Xiang Niu, Caroline Mccauley, Karishma Rahman, Ashley Hine, Nikollaq Vozhilla, Edward A. Fisher and P’ng Loke. Heterogeneity of plaque macrophages derived from CX3CR1+ monocyte precursors in atherosclerosis progression and regression at a single-cell level. J. Immunol., 200 (1 Supplement), May, 2018.
Jian-Da Lin, Jianya Peng, Constance McElrath, Hsiang-Chi Tseng, Ningguo Feng, Adrish Sen, Russell K. Durbin, Joan E. Durbin, Harry B. Greenberg and Sergei V. Kotenko. Role of IFN-lamda in the pathogenesis of heterologous rotavirus infection in suckling mice. Cytokine, Volume 87, Page 94, November, 2016.
Constance McElrath, Jian-Da Lin, Jianya Peng, Raghavendra Sridhar, Vanessa Espinosa, Orchi Dutta, Hsiang-Chi Tseng, Heidi Risman, Marvin Sandoval, Mark Galan, Joan E. Durbin, Amazrliz Rivera and Sergei V. Kotenko. Role of IFNs in gastro-intestinal mucosal inflammation. Cytokine, Volume 87, Page 141, November, 2016.
l Marvin Sandoval, Jian-Da Lin, Qing Li, Heidi Risman, Russell K. Durbin, Sergei V. Kotenko and Joan E. Durbin. IFN-lamda production is mediated by epithelial cell in the small intestine and CD8 alpha dendritic cells in the spleen in vivo. Cytokine, Volume 87, Page 118, November, 2016.
Jian-Da Lin, Ningguo Feng, Adrish Sen, Murugabaskad Balan, Hsiang-Chi Tseng, Constance McElrath, Russell K. Durbin, Joan E. Durbin, Harry B. Greenberg, Sergei V. Kotenko. Role of type I and type III interferons in intestinal immunity to homologous and heterologous rotavirus infection. Cytokine, Volume 76, Issue 1, November, 2015.
Marvin Sandoval, Troy Cline, Jian-Da Lin, Sergei V. Kotenko, Russell K. Durbin, Joan E. Durbin. Resistance to respiratory syncytial virus replication is STAT1 and STAT2 dependent, but I interferon independent. Cytokine, Volume 63, Issue3, September, 2013.