Publications

Publications (most recent first) 

1. Levesque MV, Cartier A, Lin YC, Sah RK, Zhang H, Chaube B, Bhaumik M, Körbelin J, Suárez Y, Fernández-Hernando C, Hla T. Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak. J Biol Chem. 2025 Jul 3:110455. doi: 10.1016/j.jbc.2025.110455. Online ahead of print.

2. Chatterjee A, Acharya D, Bhandari N, Bhat P, Chaube B#, Shukla S#. TGF/J regulated small GTPase RHOV interacts with PEAK1 and drives MYC expression to promote cellular proliferation, migration, and etoposide resistance. bioRxiv. Published online April 18, 2025. doi:10.1101/2025.04.18.649622. (# Corresponding author)

3. Bhandari N, Acharya D, Chatterjee A, Yelshetti S, Bhat B, Chaube B#, Shukla S#. MRPL47 Deficiency Drives Mitochondrial Dysfunction via ROS/p38-MAPK/CDKN1A Signaling in Non-Small Cell Lung Cancer. bioRxiv 2025.02.17.638626; doi: https://doi.org/10.1101/2025.02.17.638626. (# Corresponding author)

4. Acharya D, Chatterjee A, Bhandari N, Roy P, Agrawal M, Chaube B#, Shukla S#. GJB3, a gap junction gene, supports cell growth by mediating cystine uptake and regulating cellular stress pathways in SLC7A11 low adenocarcinomas. bioRxiv 2024.12.03.626548; doi: https://doi.org/10.1101/2024.12.03.626548(# Corresponding author)

5. Citrin KM# , Chaube B#, Fernández-Hernando C, Suárez  Y. Intracellular Endothelial metabolism in vascular functions and dysfunction. Trends in Endocrinology and Metabolism 2024 Dec 12:S1043-2760(24)00296-0. doi: 10.1016/j.tem.2024.11.004. Online ahead of print. (#Co-First Author) 

6. Boutagy NE, Gamez-Mendez A, Fowler JW, Zhang H, Chaube B, Esplugues E, Lee S, Horikami D, Zhang J, Citrin KM, Singh AK, Coon BG, Suarez Y, Fernandez-Hernando C, Sessa WC. Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice. Journal of Clinical Investigation. 2024 Jan 4:e170453. doi: 10.1172/JCI170453. Online ahead of print. PMID: 38175710. 

7. Chaube B, Citrin KM, Sahraei M, Singh AK, de Urturi DS, Ding W, Pierce RW, Raaisa R, Cardone R, Kibbey R, Fernández-Hernando C, Suárez Y. Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis. Nature Communications. 2023 Dec 12;14(1):8251. doi: 10.1038/s41467-023-43900-0.PMID: 38086791. 

8. Singh AK, Chaube B, Citrin KM, Fowler JW, Lee S, Catarino J, Knight J, Lowery S, Shree S, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross TT, Malaker S, Suárez Y, Fernández-Hernando C, Grabinska K, Sessa WC. Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma. bioRxiv 2023.11.13.566870.

9. Chaube B* and Malvi M*. Editorial: Cancer Metabolism: Molecular Insights into Metabolic Crosstalk in the Tumor Microenvironment and Implications for Therapy. Frontiers in Oncology, 2023 13:1289397. doi: 10.3389/fonc.2023.1289397. (* Corresponding author). 

10. Bhat N, Esteghamat F, Chaube B, Gunawardhana K, Mani M, Thames C, Jain D, Ginsberg HN, Fernandes-Hernando C, Mani A. TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut-liver crosstalk. FASEB J. 2022 Mar;36(3):e22185. doi: 10.1096/fj.202101607R. 

11. Singh AK#, Chaube B#, Zang X, Sun J, Chitrin KM, Canfran-Duqe A, Aryal B, Rotllan N, Varela L, Lee RG, Horvath TL, Price NL, Suarez Y*, Fernandez-Hernando C*. Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice. Journal of Clinical Investigation. 2021 Jul 13;140989. doi: 10.1172/JCI140989. PMID: 34255741. (#Co-First Author) 

12. Leigh Goedeke , Canfran-Duque A, Rotllan N, Chaube B, Thompson B, Lee RG, McDonald J, Lasuncion M, Suarez Y, Fernandez-Hernando C. MMAB promotes negative feedback control of cholesterol homeostasis. Nature Communications, 2021 Nov 8;12(1):6448. doi: 10.1038/s41467-021-26787-7. 

13. AK Singh#, B Chaube#, A Canfran-Duque, X Zhang, NL Price, B Aryal, Sun J, Citrin KM, Rotllan N, Lee R, Suarez Y*, Fernandez-Hernando C*. Liver-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice. bioRxiv 2020. doi: https://doi.org/10.1101/2020.06.02.130922.

14. Sahraei M, Chaube B, Liu Y, Sun J, Kaplan AR, Price NL, Ding W, Oyaghire SN, Garcia-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, Fernandez-Hernando C, Suarez Y. Suppression of miR-21 Activity in Tumor Associated Macrophages Promotes an Antitumor Immune Response. Journal of Clinical Investigation. 2019 Dec 2;129(12):5518-5536. PMID: 31710308. 

15. Singh AK, Aryal B, Chaube B, Roltan N, Varela L, Horvath TL, Suarez Y, Fernandez-Hernando C. Brown adipose tissue-derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis. Molecular Metabolism. 2018 Mar 29. pii: S2212-8778(18)30227-8. PMID: 29627378. 

16. Aryal B, Singh AK, Zhang X, Varela L, Roltan N, Goedeke L, Chaube B, Camporez JP, Vatner D, Horvath TL, Shulman GI, Suarez Y#, Fernandez-Hernando C#. Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. JCI Insight. 2018 Mar 22;3(6). pii: 97918. PMID: 29563332. 

17. Chaube B and Bhat MK. AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells. Cell Death and Disease. 2016 Jan 14;7:e2044. doi: 10.1038/cddis.2015.404. PMID: 26775698. IF: 9.68.

18. Chaube B, Malvi P, Singh SV, Mohammad N, Viollet B, Bhat MK. AMPK maintains energy homeostasis and survival in cancer cells under metabolic stress by regulating p38/PGC-1α-mediated mitochondrial biogenesis. Cell Death and Discovery. 2015; 1, 15063; doi:10.1038/cddiscovery.2015.63. PMID: 27551487. 

19. Chaube B, Malvi P, Singh SV, Mohammad N, Meena AS, Bhat MK. Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression. Oncotarget. 2015 Nov 10;6(35):37281-99. doi: 10.18632/oncotarget.6134. PMID: 26484566. 

20. Singh SV#, Chaube B#, Mayengbam SS, Singh A, Malvi P, Mohammad N, Deb A, Bhat MK. Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter. Biochim Biophys Acta Mol Basis Dis. 2020 Nov 16;166011. doi: 10.1016/j.bbadis.2020.166011. PMID: 33212188 (#Co-First Author), 

21. Singh SV, Ajay AK, Mohammad N, Malvi P, Chaube B, Meena AS, Bhat MK. Proteasomal inhibition sensitizes cervical cancer cells to mitomycin C-induced bystander effect: the role of tumor microenvironment. Cell Death and Disease. 2015 Oct 22; 6: e1934. doi: 10.1038/cddis.2015.292. PMID: 26492368. 

22. Malvi P, Chaube B, Singh SV, Mohammad N, Pandey V, Vijayakumar MV, Radhakrishnan RM, Vanuopadath M, Nair SS, Nair BG, Bhat MK. Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance. Cancer & Metabolism. 2016 Dec 7;4:21. eCollection 2016. PMID: 27980732. 

23. Malvi P, Chaube B, Pandey V, Vijayakumar MV, Boreddy PR, Mohammad N, Singh SV, Bhat MK. Obesity-induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokines. Molecular Oncology. 2015 Mar; 9(3):689-703. PMID: 25499031 

24. Malvi P, Chaube B, Singh SV, Mohammad N, Vijayakumar MV, Singh S, Chauhan S, Bhat MK. Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state. Cancer & Metabolism. 2018, 6 (1), 1-14 PMID: 29568521. 

25. Malvi P, Piprode V, Chaube B, Pote ST, Mittal M, Chattopadhyay N, Wani MR, Bhat MK. High-fat diet promotes achievement of peak bone mass in young rats. Biochemical Biophysical Research Communications. 2014 Nov 1; 455(1-2):133–138. PMID: 25450704  

26. Mohammad N, Singh SV, Malvi P, Chaube B, Athavale DA, Bhat MK. Cholesterol depletion by methyl-β-cyclodextrin augments tamoxifen-induced cell death by enhancing its uptake in melanoma. Scientific Reports. 2015 Jul 7; 5:11853. PMID: 26149967. 

27. Mohammad N, Malvi P, Meena AS, Singh SV, Chaube B, Vannuruswamy G, Kulkarni MJ, Bhat MK. Cholesterol depletion by methyl-β-cyclodextrin augments tamoxifen-induced cell death by enhancing its uptake in melanoma. Molecular Cancer. 2014 Sep 1; 13:204. PMID: 25178635.

28. Pandey V, Chaube B, Bhat MK. Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. Journal of Cellular Biochemistry. 2011 Oct; 112(10):2942-52. PMID: 21630327. 

Books/Book Chapters

1. Contributed and edited various chapters of the book entitled “Metabolism & Medicine – The metabolic landscape of health and Disease, Volume II ” CRC Press, Taylor & Francis group.

2. Chaube, B., Malvi, P., eds. (2023). Cancer metabolism: Molecular insights, metabolic crosstalk in the tumor microenvironment, and implications for therapy. Lausanne: Frontiers Media SA. doi: 10.3389/978-2-8325-3505-9. ISSN: 1664-8714.