ISCB Short Course in Budapest

Post date: Sep 3, 2014 6:23:50 PM

ISCB Short Course in Budapest

27-28 November 2014

Course title: Novel approaches to multiple test problems, with applications to adaptive designs and dose finding

Frank Bretz, Global Head of the Statistical Methodology Group, Novartis

Franz König, Associate Professor, Section of Medical Statistics, Medical University of Vienna

Abstract

The issue of multiplicity often arises in the design and analysis of clinical trials. Common multiple test problems include comparing several doses with a control, assessing the benefit of a new treatment for more than one endpoint, combined non-inferiority and superiority testing, or any combination thereof.

One particular application arises in confirmatory adaptive design trials, when multiplicity adjustments must be made to account for adaptations made during the study. Another application arises in dose finding studies, where multiplicity due to model uncertainty has to be addressed.

This 1.5-day course will begin with the introduction of the basic fundamentals of multiplicity methodology, and continue through novel methods and strategies for addressing multiplicity concerns. These techniques will be demonstrated with several case studies.

The research presented has received funding from the European Union Seventh Framework Programme [FP7 2007-2013] under grant agreement No.: 602552 (IDEAL, ideal.rwth-aachen.de/) and No.: 290025 (Marie Curie Initial Training Network MEDIASRES, http://www.mediasres- itn.eu).