Postdoctoral Fellow

Postdoctoral research associate (September 2018 – December 2021)

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, FL 32603.

Advisor: Timothy J. Garrett, Ph.D. (https://pathology.ufl.edu/profile/garrett-timothy/) 

From 2018 to 2021: My research efforts contributed to 20 peer-reviewed manuscripts where 11 were first/co-first authored including, 1 co-corresponding authored.

1) Designed, conducted, and significantly contributed to multiomics projects to discover molecular mechanisms and therapeutic in human diseases. Examples include:

• Uncovered niclosamide role in SARS-CoV-2 infected cells by lowering ether lipid (Garrett, Coatsworth, Mahmud et al., Front. Microbiol. 2023, PMID: 37901834; Mahmud & Garrett, JASMS, 2020, PMID: 32880453)

• Obesity-dependent chemerin mechanisms to drive kidney cancer and antibody-based therapy development (Tan & Mahmud et al., Cancer Discovery, 2023, PMID: 33757970)

• Discovered the utilization of leucine to produce lipid droplets via autophagy by cancer cells under acidic conditions (Pillai & Mahmud et al., Cell Reports, 2022, PMID: 35545051)

2) Designed, conducted, and significantly contributed to multiomics projects to discover biomarkers, molecular mechanisms, and therapeutic targets in human diseases. Examples include:

• Multiomics tool for childhood malnutrition (Mahmud et al., Analytical Chemistry, 2019, PMID: 31682425)

• Integrated RNA and metabolites for prostate cancer screening and mechanism study (Lee & Mahmud et al., Scientific Reports, 2020, PMID: 32111915)

• Integrated multiomics for children medulloblastoma biomarkers such as RNA, metabolites, and lipids (Lee & Mahmud et al., Acta Neuropathol Commun. 2022, PMID: 35209946), oncogenic circular RNA circ_63706 (Katsushima, Pokhrel, Mahmud et al., Acta Neuropathol Commun. 2023, PMID: 36899402), and tumor suppressor miRNA-211 (Yuan & Mahmud et al., Acta Neuropathol Commun. 2023, PMID: 38115140) 

3) Designed, conducted, and significantly contributed to multiomics projects to discover biomarkers and their diagnostic tools in human diseases. Examples include:

• Segmented flow mass spectrometry (SF-MS) for small molecule identification and cancer differentiation (Mahmud & Pinto et al., Journal of Proteome Research, 2020, PMID: 32216312)

• Paper spray ionization mass spectrometry (PSI-MS) for small molecule identification and cancer differentiation (Mahmud & Pinto et al., Analytical Chemistry, 2021, PMID: 34043339)

• Data modeling algorithms to diagnose cancer (Mahmud & Pinto et al., Analytical Chemistry, 2021, PMID: 35060703)

• Managed and mentored 1 full-time research technician and 2 graduate students

• Published 20 conference abstracts, including 10 poster presentations and 5 oral presentations

• Directly participated in 5 grant applications and 8 postdoctoral fellowships, where I secured 4 fellowships

• Developed state-of-the-art skills related to multiomics, including genomics, proteomics, metabolomics, and lipidomics experimental research design and data analysis.

4) I learned and served in numerous teaching and leadership training programs including:

• Demonstration of mutliomics techniques such as metabolomics and lipidomics to visitors, graduate students, and high school scholars

• Completed a week-long training on LEADERSHIP IN ACTION in Biomedical Research organized by the University of Florida College of Medicine (June 2019)

• Acquired “Preparing Future Faculty” certification from the Center of Teaching Excellence at the University of Florida, Gainesville, FL (Spring 2020).

• Taught a graduate class in the UF college of medicine core course (GMS6001) in Fall 2018 & 2019, focusing on an introduction to big data for Biomedical Research (3-week mini-course)

• Taught metabolomics summer (2019) and winter school (2020) workshops organized by the Southeast Center for Integrated Metabolomics (SECIM) at UF

• Organized metabolomics journal clubs at the Garrett lab and SECIM during my postdoc