Publication
Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy
Shinozaki Y, Leung A, Namekata K, Saitoh S, Nguyen HB, Takeda A, Danjo Y, Morizawa Y, Shigetomi E, Sano F, Yoshioka N, Takebayashi H, Ohno N, Segawa T, Miyake K, Kashiwagi K, Harada T, Ohnuma S, Koizumi S.
Science Advances, 2022, 8, abq1081.
【解説】「緑内障」は、日本で最大の失明原因となる病気です。これまで、緑内障は主に眼圧が原因と考えられていましたが、実際は日本の患者の多くは正常な眼圧を示すため、眼圧以外の要因に関する研究が必要でした。最新の研究から、グリア細胞の異常が緑内障の原因となることが明らかとなりました。脳や網膜に存在する「グリア」と呼ばれる非神経細胞のうち、特に「アストロサイト」という細胞でコレステロール輸送に関わる分子であるABCA1が不足すると、炎症の惹起と神経の過度な興奮が緑内障の発症につながることが明らかになりました。
Glaucoma is the leading cause of blindness in Japan. While elevated intraocular pressure (IOP) has been thought to be the main cause, most Japanese glaucoma patients have normal IOP levels. This led us to explore other factors contributing to the disease. Our recent study revealed that dysfunction in glial cells is responsible for normal-tension glaucoma. Glia are non-neuronal cells found in the nervous system, such as the brain and retina. Specifically, astrocytes, a type of glial cell, can trigger normal-tension glaucoma by causing inflammation and excessive nerve activity when the cholesterol exporter ABCA1 is absent in the cell.
Loss of P2Y1 receptors triggers glaucoma-like pathology in mice
#Hamada K, #Shinozaki Y, Namekata K, Matsumoto M, Ohno N, Segawa T, Kashiwagi K, Harada T, Koizumi S. (#co- first authors)
British Journal of Pharmacology, 2021, 178: 4552-4578.
In this study, we found that topical application of P2Y1 receptor agonist transiently reduces intraocular pressure in mice. P2Y1 receptors were expressed in the ciliary body and trabecular meshwork which are essential for aqueous production/draining. Loss of P2Y1R caused chronic ocular hypertension and age-associated glaucoma like phenotypes.
Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy
Shinozaki Y, Kashiwagi K, Namekata K, Takeda A, Ohno N, Robaye B, Harada T, Iwata T, Koizumi S.
JCI Insight, 2017, 2: e93456.
We found that UDP, an endogenous agonist for P2Y6 receptor, reduced intraocular pressure. P2Y6 receptors were expressed in the non-pigmented epithelium of the ciliary body which regulates the production of aqueous humor. Lack of P2Y6 receptor showed chronic ocular hypertension, age-associated RGC degeneration and visual impairment.
Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation
Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S.
Cell Report, 2017, 19: 1151-1164.
Microglia are highly sensitive to brain environment. We found that microglia become reactive at early stages after traumatic brain injury and regulate astrocytic responses. Microglia-derived cytokines down-regulated astrocytic P2Y1R thereby enhancing their reactivity and protective responses.
Direct Observation of ATP-induced Conformational Changes in Single P2X4 Receptors
*Shinozaki Y, Sumitomo K, Tsuda M, Koizumi S, Inoue K, Torimitsu K. (*Corresponding Author)
PLoS Biology, 2009, 7: e1000103.
In this study, we used atomic force microscopy (AFM) to visualize single P2X4 receptor complex. AFM enables us to directly visualize surface structure of various biological molecules including nucleic acids, lipids and proteins. We purified P2X4 receptor complex and deposited it on mica or reconstituted into supported lipid bilayers. ATP stimulation evoked relatively slow structural changes known as "pore-dilation". Our results provided the evidence showing P2X4R exhibit pore dilation without adapter proteins such as connexin or pannexin.
Full Publication
2024
[74] Shigetomi E, et al.
Nat Coms, accepted
2023
[74] Shinozaki Y*, Namekata K, Guo X, Harada T
Glial cells as a promising therapeutic target of glaucoma: beyond the IOP
Front Ophthalmol (Glaucom), 3:1310226. (*Corresponding author)
[73] Le Y-P, Saito K, Parajuli B, Sakai K, Kubota Y, MIyakawa M, Shinozaki Y, Shigetomi E, Koizumi S.
Severity of peripheral infection differentially affects brain functions in mice via microglia-dependent and -independent mechanisms. IJMS, 2023, 24 (24), 17597. (IF = 6.1)
[72] 篠崎陽一
神経科学トピックス：グリアの異常が目の病気の原因となる
神経科学ニュース 3, 47, 2023
[71] 篠崎陽一
緑内障：緑内障とグリア機能
[70] 篠﨑陽一，Alex Leung，行方和彦，齋藤成，Huy Bang Nguyen，武田明子，檀上洋右，森澤陽介，繁冨英治， 佐野史和，吉岡望，竹林浩秀，大野伸彦，瀬川高弘，三宅邦夫，柏木賢治，原田高幸，大沼信一，小泉修一.
アストロサイトのABCA1 欠損は視神経症を誘発する
日本眼科学会雑誌127(5), 582-583, 2023.
[69] 篠崎陽一、小泉修一
アストロサイトの機能異常による正常眼圧緑内障発症機構
[68] Saito K, Shigetomi E, Shinozaki Y, Kobayashi K, Parajuli B, Kubota Y, Sakai K, Miyakawa M, Horiuchi H, Nabekura J, Koizumi S.
Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model.
Brain, 2023, awad358 (IF = 14.5) Press Release (in Japanese)
[67] Namekata K, Tsuji N, Guo X, Nishijima E, Honda S, Kitamura Y, Yamasaki A, Kishida M, Takeyama J, Ishikawa H, Shinozaki Y, Kimura A, Harada A, Harada T. Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation.
Cell Death Discovery , 2023, 9: 166 (IF = 7.1)
[66] Ihara T, Shinozaki Y, Shigetomi E, Danjo Y, Tsuchiya S, Kanda M, Kamiyama M, Takeda M, Koizumi S, Mitsui T.
G protein-coupled receptor 55 activated by palmitoylethanolamide is associated with the development of nocturia associated with circadian rhythm disorders.
Life Sci 2023, 332, 122072-122072.
[65] Ono Y, Yoshino O, Ito M, Tanaka K, Tokura Y, Ogawa Y, Tagaya H, Ogi M, Shinozaki Y, Koizumi S, Hirata S. Endometriotic cell-derived adenosine triphosphate (ATP) promotes the fibrosis of endometriotic lesions via eosinophil activation. J Reprod Immunol. 2023, 156: 103885.
[64] Shinozaki Y, Kashiwagi K, Koizumi S
Astrocyte Immune Functions and Glaucoma (Review)
Int J Mol Sci, 2023, 24(3), 2747 (IF = 6.1)
[63] Shinozaki Y, Saito K, Kashiwagi K, Koizumi S.
Ocular P2 receptors and glaucoma. (Invited Review)
Neuropharmacology, 2023, 222: 109302. (IF = 5.3)
2022
[62] Shinozaki Y, Leung A, Namekata K, Saitoh S, Nguyen HB, Takeda A, Danjo Y, Morizawa MY, Shigetomi E, Sano F, Yoshioka N, Takebayashi H, Ohno N, Segawa T, Miyake K, Kashiwagi K, Harada T, Ohnuma SI, Koizumi S.
Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy.
Science Advances, 2022, 8, abq1081. (IF = 15.0)
Press Release (UY, TMiMS, NIPS, Niigata Univ, JST-China)
Web News (日本経済新聞Web, CB News, Yahoo, 医療NEWS (QLifePro), iptops.com, 信濃毎日新聞, NEWS Twit, Sawai medical site, 日本の研究.com)
[61] 篠崎陽一、Parajuli Bijay
網膜ミクログリアと緑内障 -非自律性神経変性機構と治療標的の可能性-
[60] Parajuli B, Shinozaki Y, Shigetomi E, Koizumi S. (2022) Transplantation of Human Induced Pluripotent Stem Cell-derived Microglia in Immunocompetent Mice Brain via Non-invasive Transnasal Route.
[59] Danjo Y, Shigetomi E, Hirayama Y, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata K, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J, Koizumi S.
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice.
JEM, 2022, 219: e20210989. (Press Release) (IF = 15.3)
[58] Parajuli B, Shinozaki Y, Shigetomi E, Koizumi S.
Transplantation of Human Induced Pluripotent Stem Cell-derived Microglia in Immunocompetent Mice Brain via Non-invasive Transnasal Route. J. Vis. Exp., 2022, 183, e63574.
[57] Danjo Y#, Shinozaki Y#, Natsubori A, Kashiwagi K, Kanji F Tanaka, Koizumi S.
The Mlc1 promoter directs Muller cell-specific gene expression in the retina.
TVST ,2022, 11: 25. (IF = 3.1)
[56] Ihata T, Shimura H, Tsuchiya S, Kanda M, Kira S, Sawada N, Takeda M, Mitsui T, Shigetomi E, Shinozaki Y, Koizumi S
Sci Rep, 2022, 12: 3050.
2021
[55] Hamada K#, Shinozaki Y#, Namekata K, Matsumoto M, Ohno N, Segawa T, Kashiwagi K, Harada T, Koizumi S.
Loss of P2Y1 receptor triggers glaucoma-like pathology in mice.
Br J Pharmacol. 2021, 178: 4552-4571. (Press Release) (IF = 9.5)
[54] Parajuli B, Saito H, Shinozaki Y, Miwa H, Yoneda S, Omachi S, Asaki T, Takahashi K, Fujita M, Nakashima K, Koizumi S.
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
GLIA, 2021, 69: 2332-2348. (IF = 8.1)
[53] Tanaka M, Parajuli B, Shigetomi E, Nagatomo H, Shinozaki Y, Hirayama Y, Saito K, Kubota Y, Danjo Y, Lee JH, Kim SK, Nabekura J, Koizumi S.
Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
GLIA, 2021, 69: 2546-2558. (IF = 8.1)
[52] Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Sugita K, Aihara M, Koizumi S.
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus
JCI Insight, 2021, 6: e135391.
[51] Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S, Sawada T.
Development of a label-free ATP imaging sensor for analyzing spatiotemporal patterns of ATP release from biological tissues.
Sens Act B: Chemical, 2021, 335, 129686 .
[50] Shinozaki Y, Koizumi S.
Potential role of astrocytes and Muller cells in the pathogenesis of glaucoma (Review)
J Pharmacol Sci, 2021, 145: 262-267.
2020
[49] Shinozaki Y, Koizumi S.
Potential role of glial dysfunction in pathogenesis of glaucoma (Japanese)
Folia Pharmacol. Jpn. 2020, 155:87-92.
2019
[48] Ihara T, Nakamura Y, Mitsui T, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Koizumi S, Takeda M.
Intermitttent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia.
[47] Shinozaki Y, Danjo Y, Koizumi S
Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration
Journal of Neurochemistry, 2019, 151: 64-78.
2018
[46] Hoshi T, Toyama T, Shinozaki Y, Koizumi S, Lee JY, Naganuma A and Hwang GW
Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures.
J. Toxicol. Sci. 2019, 44: 471-479.
[45] Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, Takeda A, Ngoc Le HP, Hayashi H, Hiasa M, Moriyama Y, Ikenaka K, Tanaka KF, Koizumi S.
Anti-depressesant fluoxetine reveals its therapeutic effect via astrocytes.
EBioMed 2018, 32: 72-83
[44] #Takeda A, #Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J and Koizumi S. Microglia mediate non-cell-autonomous cell death of retinal ganglion cells
GLIA 2018, 66: 2366-2384. (#co-first authors)
[43] Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Hirayama Y, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M and Koizumi S.
The Oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium.
2017
[42] Shinozaki Y, Kashiwagi K, Namakata K, Takeda A, Ohno N, Robaye B, Harada T, Iwata T and Koizumi S.
Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy
JCI Insight 2017, 2(19): e93456. (Press Release)
[41] Ihara T, Mitsui T, Nakamura Y, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M and Koizumi S.
The circadian expression of Piezo1, TRPV4, Coonexin26 and VNUT, associated with expression levels of the clock genes in mouse primary cultured urothelial cells.
Neurourology and Urodynamics,2018, 37: 942-951
[40] Katoh M, Wu B, Ngyen HB, Thai TQ, Yamasaki R, Lu H, Rietsh AM, Zorlu MM, Shinozaki Y, Saitoh Y, Saitoh S, Satoh K, Ikenaka K, Koizumi S, Ransohoff RM and Ohno N
Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation.
[39] Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF and Koizumi S
Transformation of astrocytes to a neuroprotective phenotype by microglia via P2Y1 receptor downregulation.
Cell Rep 2017, 19: 1151-1164. (Press Release)
[38] Ihara T, Mitsui T, Nakamura Y, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Andersson KL, Nakao A, Takeda M and Koizumi S
Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26 and VNUT in an Ex Vivo Mouse Bladder Mucosa.
PLoS One 2017, 12: e0168234
2016
[37] Nakagomi H, Yoshiyama M, Mochizuki T, Miyamoto T, Komatsu R, Imura Y, Morizawa Y, Hiasa M, Miyaji T, Kira S, Araki I, Fujishita K, Shibata K, Shigetomi E, Shinozaki Y, Ichikawa R, Uneyama H, Iwatsuki K, Nomura M, Groat WC, Moriyama Y, Takaeda M and Koizumi S
Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase.
[36] Ihara T, Mitsui T, Kira S, Miyamoto T, Sawada N, Nakagomi H, Yoshiyama M, Takeda M, Nakamura Y, Nakao A, Shinozaki Y, Koizumi S
The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria
Neurourol Urodyn, 2016, 36: 1034-1038.
[35] Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee H, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S* and Nabekura J*
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
J Clin Invest, 2016, 126: 1983-1997. (Press Release)
[34] Taguchi M*, Shinozaki S*, Kashiwagi K, Shigetomi E, Robaye B, Koizumi S. (*co-first)
Muller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y6 receptor signals
J Neurochem, 2016, 136: 741-751.
2014
[33] Shinozaki Y, Nomura M, Iwatsuki K, Moriyama Y, Gachet C, Koizumi S
Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission
[32] Shinozaki Y*, Tanaka A, Kasai N, Torimitsu K, Sumitomo K.
Ligand-induced structural changes in membrane-reconstituted ion channel observed with atomic force microscopy.
Appl. Phys. Express. 2014, 7(2), 027001 *corresponding author
2013
[31] Imura Y, Morizawa Y, Komatsu R, Shibata K, Shinozaki Y, Kasai H, Moriishi K, Moriyama Y, Koizumi S.
Microglia release ATP by exocytosis.
[30] Noguchi Y#, Shinozaki Y#, Fujishita K#, Shibata K, Imura Y, Morizawa Y, Gachet C, Koizumi S. (#equal contribution)
Astrocytes protect neurons against methylmercury via ATP/P2Y1 receptor-mediated pathways in astrocytes
[29] Takata F, Dohgu S, Yamaguchi A, Matsumoto J, Machida T, Fujishita K, Shibata K, Shinozaki Y, Sato K, Kataoka Y, Koizumi S.
PLoS One 2013, 8, e55166
2012
[28] K. Sumitomo*, A. McAllister, Y. Tamba, Y. Kashimura, A. Tanaka, Y. Shinozaki, and K. Torimistsu K
Ca2+ ion transport through channels formed by alpha-hemolysin analyzed using a microwell array on a Si substrate
Biosens Bioelectron, 31, 445-450
2011
[27] Shinozaki Y*, Sumitomo K, Tanaka A, Kasai N, Torimitsu K.
Examination of Ion Channel Protein Orientation in Supported Lipid Bilayers
Appl. Phys. Express (APEX), 2011, 4, 107001.
[26] Shibata K, Sugawara T, Fujishita K, Shinozaki Y, Matsukawa T, Suzuki T, Koizumi S.
The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice.
PLoS One, 2011, 6: e23510 (selected as the top 10% most cited PLoS One article)
[25] 篠崎陽一*、住友弘二、河西奈保子、田中あや、鳥光慶一
原子間力顕微鏡を用いた生体分子のトポロジー観察
2010
[24] K. Sumitomo*, Tamba Y, Shinozaki Y, Torimitsu K.
Confinement of fluorescent probes in micro-wells on Si substrates by sealing with lipid bilayer
Appl. Phys. Express (APEX), 2010, 3, 107001.
[23] Nakashima H*, Furukawa K, Kashimura Y, Sumitomo K, Shinozaki Y, Torimitsu K.
Pattern formationa and molecular transport of histidine-tagged GFPs using supported lipid bilayers.
Langmuir 2010, 26(15), 12716-12721.
[22] Shinozaki Y*, Sumitomo K, Furukawa K, Miyashita H, Tamba Y, Kasai N, Nakashima H, Torimitsu K.
Visualization of membrane protein suspended over nanoscale well.
Appl. Phys. Express (APEX), 2010, 3, 027002.
(APEX top pageに掲載、Selected as Top 20 Most Downloaded Article）
2009
[21] 篠崎陽一*、住友弘二、津田誠、小泉修一、井上和秀、鳥光慶一：
高速原子間力顕微鏡を用いた受容体の一分子イメージング
日薬理誌(Folia Pharmacol. Jpn.) 134巻, 2号, 68-72, 2009年 (表紙掲載)
[20] Shinozaki Y
Direct observation of dynamics in receptor protein by atomic force microscopy
[19] 篠崎陽一
主役登場 バイオの力を通信に
NTT技術ジャーナル, 21巻, 6号, 40, 2009年
[18] 篠崎陽一
原子間力顕微鏡による受容体タンパク質の動的構造解析
NTT技術ジャーナル, 21巻, 6号, 20-23, 2009年
[17] Shinozaki Y*, Sumitomo K, Tsuda M, Koizumi S, Inoue K, Torimitsu K.
Direct observation of ATP-induced conformaitonal changes in single P2X4 receptors
PLoS Biol. 2009, 7(5) e1000103. *corresponding author (Press Release)
[16] Sumitomo K*, Shinozaki Y, Takagi D, Nakashima H, Kobayashi Y, Torimitsu K.
AFM observation of membrane proteins suspended over CNT network.
Jpn. J. Appl. Phys., 2009, 48: 08JB18.
[15] 河西奈保子、C. S. Ramanujan, 篠崎陽一、住友弘二、J. F. Ryan, 鳥光慶一
受容体タンパク質の一分子観察
化学とマイクロ・ナノシステム研究会誌、2009年、第8巻、第1号、1-6
2008
[14] Siitonen AM, Sumitomo K*, Ramanujan CS, Shinozaki Y, Kasai N, Furukawa K, Ryan JF, Torimitsu K.
Elasticity of the purple membrane measured by atomic force microscopy
Appl. Surf. Sci. 2008, 254; 7877-7880.
[13] 鳥光慶一、篠崎陽一、河西奈保子、住友弘二
単一分子レベルでのたんぱく質の機能評価
[12] Shinozaki Y*, Siitonen AM, Sumitomo K, Furukawa K, Torimitsu K.
Effect of calcium ions on lipid dynamics analyzed with fast scanning atomic force microscopy
Jpn. J. Appl. Phys. 2008, 47(7): 6164-6167.
[11] Suzuki T, Tamehiro N, Sato Y, Kobayashi T, Ishii-Watanabe A, Shinozaki Y, Nishimaki-Mogami T, Hashimoto T, Asakawa Y, Inoue K, Ohno Y, Yamanagushi T, Kawanishi T.
The novel compounds that activate farnesoid X receptor: the diversity of their effects on gene expression
J. Pharmacol. Sci. 2008, 107(3): 285-294.
2007
[10] Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, Tsuda M, B. Joshi BV, Jacobson KA, Kohsaka S, Inoue K*
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
[9] Shinozaki Y, Sato Y*, Koizumi S, Ohno Y, Nagao T, Inoue K.
Retinoic acids acting through retinoid receptors protect hipppocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of JNK and p38 mitogen-activated protein
Neuroscience, 2007, 147(1):153-63.
[8] Ishida S, Tanabe H, Shinozaki Y, Koyano S, Kagechika H, Shudo K, Ozawa S, Sawada JI, Ohno Y, Inoue K.
How DNA microarray technology contributes to the retinoid evaluations
In "Vitamin A: a new research", Nova Science Publishers, 2007
2006
[7] Shinozaki Y, Koizumi S, Ohno Y, Nagao T, Inoue K*
Extracellular ATP counteracts the ERK1/2-mediated death-promoting signaling cascades in astrocytes.
GLIA 2006, 54: 606-618 (GLIA 2005, 2006の一連の研究成果が日本薬理学会誌2007年9月号の表紙に掲載）
[6] Suzuki T, Nishimaki-Mogami T, Kawai H, Kobayashi T, Shinozaki Y, Sato Y, Hashimoto T, Asakawa Y, Inoue K, Ohno Y, Hayakawa T, Kawanishi T*
Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives.
2005
[5] Shinozaki Y, Koizumi S, Ishida S, Sawada JI, Ohno Y, Inoue K*
Cytoprotection against oxidative stress-induced damage of astrocytes by extracellular ATP via P2Y1 receptors.
2004
[4] Ishida S, Shigemoto-Mogami Y, Shinozaki Y, Kagechika H, Shudo K, Ozawa S, Sawada JI, Ohno Y, Inoue K*
Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and AM80-induced HL-60 cell differentiation revealed by DNA microarray analysis
Biochem. Pharmacol. 2004, 68: 2177-2186.
2002
[3] Shinozaki Y, Fukamiya N*, Uchiyama C, Okano M, Tagahara K, Bastow KF, Lee KH
Multidrug resistance cancer cells susceptibility to cytotoxic taxane diperpenes from Taxus yunnanensis and Taxus chinensis.
Bioorg. Med. Chem. Lett. 2002, 12: 2785-2788.
[2] Shinozaki Y, Fukamiya N*, Okano M, Nehira T, Tagahara K, Zhang SX, Lee KH
Dantaxusins C and D, two novel taxoids from Taxus yunnanensis.
J. Nat. Prod. 2002, 65: 371-374.
2001
[1] Shinozaki Y, Fukamiya N*, Fukushima M, Okano M, Nehira T, Tagahara K, Zhang SX, Zhang DC, Lee KH
Dantaxusins A and B, two new taxoids from Taxus yunnanensis.
J. Nat. Prod. 2001, 64: 1073-1076.
Review
[4] Shinozaki Y, Saito K, Kashiwagi K, Koizumi S
(title)
Neuropharmacol 2022, ##
[3] 篠崎陽一、パラジュリビジェイ、小泉修一
(title)
ファルマシア 2022, ##
[2] Shinozaki Y, Koizumi S.
Potential role of astrocytes and Muller cells in the pathogenesis of glaucoma (Review)
J Pharmacol Sci, 2021, 145: 262-267.
2020
[1] 篠崎陽一, 小泉修一.
グリア細胞の機能異常による緑内障発症メカニズム