2025年

Original articles

1. Elfeky M, Goto S, El-Far A, Okamatsu-Ogura Y, Kimura K. (2025) Adiponectin inhibits chemokine-induced cell migration via direct interaction with platelet factor 4. J Clin Biochem Nutr. 77(2):131–135. doi: 10.3164/jcbn.24-230.

2. Son YL, Hou J, Kato-Suzuki M, Okamatsu-Ogura Y, Watase M, Kiyonari H, Kondo T. (2025) Eva1 deficiency prevents obesity-induced metabolic disorders by reducing visceral adipose dysfunction. Metabolism.168:156235. doi: 10.1016/j.metabol.2025.156235. 

3. Izumi-Mishima Y, Tsutsumi R, Shiuchi T, Fujimoto S, Taniguchi M, Sugiuchi M, Tsutsumi M, Okamatsu-Ogura Y, Yoneshiro T, Kuroda M, Nomura K, Sakaue H. (2025) Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice. Elife. 13:RP99982. doi: 10.7554/eLife.99982.

4. Anan M, Kagawa K, Okamatsu-Ogura Y, Yamaguchi S, Yano-Nashimoto S. (2026) Human chorionic gonadotropin inhibits locomotion but not food intake independently of the area postrema and the nucleus tractus solitarius in female mice. Physiol Behav. 303:115151. doi: 10.1016/j.physbeh.2025.115151.

5.   Islam MM, Sasaki O, Yano-Nashimoto S, Okamatsu-Ogura Y, Yamaguchi S. (2025) Functional expression of the proton channel OTOP1 in brown adipocytes. Biochem Biophys Res Commun. 788:152835. doi: 10.1016/j.bbrc.2025.152835.

Publications other than original articles

1. 岡松優子「ベージュ脂肪細胞：白色脂肪組織の褐色化」, 富永真琴ほか編『生き物と温度の事典』, 朝倉書店

2. 岡松優子「代謝」, 日本哺乳類学会編『哺乳類学の百科辞典』, 丸善出版

Other activities

1. 岡松優子, 加藤美羅：北大獣医学部 体験スクール2025『動物のお医者さん…だけじゃない！獣医学部の世界へようこそ、研究体験ワークショップ』, 2025.2.1, 企画・開催

2024年

Original articles

1. Elfeky M, Tsubota A, Shimozuru M, Tsubota T, Kimura K, Okamatsu-Ogura Y. (2024) Regulation of mitochondrial metabolism by hibernating bear serum: Insights into seasonal metabolic adaptations. Biochem Biophys Res Commun, 736:150510. doi: 10.1016/j.bbrc.2024.150510. 

2. Kato-Suzuki M, Okamatsu-Ogura Y, Inanami O, Kimura K. (2024) Time-dependent changes in retinoids content in liver and adipose tissue after feeding of a vitamin A-deficient diet to mice. Exp Anim, 73(3):302-309. doi: 10.1538/expanim.23-0123.

3. Elfeky M, Matsuoka S, Yamamoto I, Elewa YHA, Nakamura K, Suzuki H, Kamikawa A, Okamatu-Ogura Y, Kimura K. (2024) Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning. Microsc Microanal, 30(3):552-563. doi: 10.1093/mam/ozae049.

4. Toya H, Okamatsu-Ogura Y, Yokoi S, Kurihara M, Mito M, Iwasaki S, Hirose T, Nakagawa S. (2024) The essential role of architectural noncoding RNA Neat1 in cold-induced beige adipocyte differentiation in mice. RNA, 30(8):1011-1024. doi: 10.1261/rna.079972.124.

Publications other than original articles

1. 塚田杏樹, 加藤（鈴木）美羅, 岡松優子 (2024), 生後の脂肪組織リモデリング, 褐色脂肪組織 Brown Adipose Tissue: Science and Applications, pp.57-66, シーエムシー出版.

Other activities

1. 岡松優子：北大獣医学部 体験スクール2024『動物のお医者さん…だけじゃない！獣医学部を体験してみよう』, 2024.2.23, 企画・開催

2023年

Original articles

1. Tsukada A, Okamatsu-Ogura Y*, Futagawa E, Habu Y, Takahashi N, Kato-Suzuki M, Kato Y, Ishizuka S, Sonoyama K, Kimura K. (2023) White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice. iScience, 26:107239. 

2. Ochiai K, Muto A, Seok BS, Doi Y, Iwasaki Y, Okamatsu-Ogura Y, Drucker DJ, Hira T*. (2023) Glucagon-Like Peptide-1 Is Involved in the Thermic Effects of Dietary Proteins in Male Rodents. Endocrinology, 164(6):bqad068.

3. Mishima M, Takeda S, Nagane M*, Suzuki T, Ogata M, Shima A, Aihara N, Kamiie J, Suzuki R, Mizugaki H, Okamatsu-Ogura Y, Satoh T, Yamashita T. (2023) Prebiotic effect of poly-D-3-hydroxybutyrate prevents dyslipidemia in obese mice. FASEB J, 37:e23121. 

4. Kwon J, Yeh YS, Kawarasaki S, Minamino H, Fujita Y, Okamatsu-Ogura Y, Takahashi H, Nomura W, Matsumura S, Yu R, Kimura K, Saito M, Inagaki N, Inoue K, Kawada T, Goto T*. (2023) Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes. iScience, 26:106161. 

5. Islam MM, Sasaki O, Yano-Nashimoto S, Okamatsu-Ogura Y, Yamaguchi S*. (2023) Cibacron blue 3G-A is a novel inhibitor of Otopetrin 1 (OTOP1), a proton channel. Biochem Biophys Res Commun, 665:64-70. 

Publications other than original articles

1. Saito M*, Okamatsu-Ogura Y. (2023) Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders. World J Mens Health, 41(3):489-507. 

2. 岡松優子 (2023) なぜ冬眠するのか？古くて新しい冬眠研究-脂肪組織の役割を中心に, 科学, 岩波書店, 第93号, 第9巻, pp.780-783.

3. 加藤（鈴木）美羅, 岡松優子 (2023), 哺乳類の寒冷適応における褐色脂肪組織の役割, 低温科学, 第81巻, pp.99-108.

Other activities

1. 岡松優子：北大獣医学部 体験スクール2023『動物のお医者さん…だけじゃない！獣医学部を体験してみよう』, 2023.2.18, 企画・開催

2. 岡松優子：KDDI総合研究所 季刊Nextcom vol56, インタビュー記事, 5年後の未来を探せ「ヒトにもあった脂肪を燃焼させる褐色脂肪組織 肥満対策に期待されるその仕組みを探る」

2022年

Original articles

1. Oo SM, Oo HK, Takayama H, Ishii KA, Takeshita Y, Goto H, Nakano Y, Kohno S, Takahashi C, Nakamura H, Saito Y, Matsushita M, Okamatsu-Ogura Y, Saito M, Takamura T*. (2022) Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat. Cell Rep, 38:110566. 

2. Izawa S*, Yoneshiro T, Kondoh K, Nakagiri S, Okamatsu-Ogura Y, Terao A, Minokoshi Y, Yamanaka A, Kimura K. (2022) Melanin-concentrating hormone-producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure. J Physiol, 600, 815-827. 

3. Hosomi K, Kawashima H, Nakano A, Kakino A, Okamatsu-Ogura Y, Yamashita Y, Sasaoka M, Masuda D, Yamashita S, Chen CH, Yuzuriha S, Hosoda H*. Iida H*, Sawamura T*. (2022) NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36. Cardiovasc Res, 119(4):1008-1020. 

2021年

Original articles

1. Mae J, Nagaya K, Okamatsu-Ogura Y*, Tsubota A, Matsuoka S, Nio-Kobayashi J, Kimura K. (2021) Adipocytes and Stromal Cells Regulate Brown Adipogenesis Through Secretory Factors During the Postnatal White-to-Brown Conversion of Adipose Tissue in Syrian Hamsters. Front Cell Dev Biol. 9:698692. 

2.  Yudasaka M*, Okamatsu-Ogura Y, Tanaka T, Saeki K, Kataura H. (2021) Cold-induced Conversion of Connective Tissue Skeleton in Brown Adipose Tissues. Acta Histochem Cytochem. 54, 131-141. 

3. Yoshida N, Yamashita T*, Osone T, Hosooka T, Shinohara M, Kitahama S, Sasaki K, Sasaki D, Yoneshiro T, Suzuki T, Emoto T, Saito Y, Ozawa G, Hirota Y, Kitaura Y, Shimomura Y, Okamatsu-Ogura Y, Saito M, Kondo A, Kajimura S, Inagaki T, Ogawa W, Yamada T, Hirata KI. (2021) Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity. iScience, 24:103342. 

4. Takei Y, Hirai R, Fukuda A, Miyazaki S, Shimada R, Okamatsu-Ogura Y, Saito M, Leproux P, Hisatake K, Kano H*. (2021) Visualization of intracellular lipid metabolism in brown adipocytes by time-lapse ultra-multiplex CARS microspectroscopy with an onstage incubator. J Chem Phys, 155:125102. 

5. Nishida K, Shimozuru M*, Okamatsu-Ogura Y, Miyazaki M, Soma T, Sashika M, Tsubota T. (2021) Changes in liver microRNA expression and their possible regulatory role in energy metabolism-related genes in hibernating black bears. J Comp Physiol B, 191:397-409. 

6. Nimako C, Ikenaka Y*, Okamatsu-Ogura Y, Bariuan JV, Kobayashi A, Yamazaki R, Taira K, Hoshi N, Hirano T, Nakayama SMM, Ishizuka, M. (2021) Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice. J Vet Med Sci, 83:487-500. 

7. Nabatame Y, Hosooka T, Aoki C, Hosokawa Y, Imamori M, Tamori Y, Okamatsu-Ogura Y, Yoneshiro T, Kajimura S, Saito M, Ogawa W*. (2021) Kruppel-like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes. J Diabetes Investig, 12:1144-1151. 

8. Matsuoka S, Suzuki H, Kato C, Kamikawa-Tokai M, Kamikawa A, Okamatsu-Ogura Y, Kimura K*. (2021) Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland. J Histochem Cytochem, 69:373-388. 

9. Kitano T, Eguchi R, Okamatsu-Ogura Y, Yamaguchi S, Otsuguro KI*. (2021) Opposing functions of alpha- and beta-adrenoceptors in the formation of processes by cultured astrocytes. J Pharmacol Sci, 145:228-240. Boonyarattanasoonthorn T, Sato K, Okamatsu-Ogura Y, Morimatsu M, Agui T*. (2021) The response of adipose tissues to Mycoplasma pulmonis and Sendai virus infection in C57BL/6 and DBA/2 mice. J Vet Med Sci, 83:403-411. 

Publications other than original articles

1. Okamatsu-Ogura Y, Saito M*. (2021) Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis. Diabetes Metab J, 45(6):840-852. 

2. 岡松優子（2021）食と栄養による脂肪組織の機能制御, 生化学, 公益社団法人日本生化学会, 第93巻, 第1号, pp22-34.

2020年

Original articles

1. Okamatsu-Ogura Y*, Kuroda M, Tsutsumi, R, Tsubota A, Saito M, Kimura K, Sakaue H. (2020) UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice. Metabolism, 113:154396.

2. Oiwa Y, Oka K, Yasui H, Higashikawa K, Bono H, Kawamura Y, Miyawaki S, Watarai A, Kikusui T, Shimizu A, Okano H, Kuge Y, Kimura K, Okamatsu-Ogura Y**, and Miura K**. (2020) Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal. Sci Rep, 10:19488. 

3. Bariuan JV, Okamatsu-Ogura Y*, Tsubota A, Matsuoka S, Saito M, Kimura K. (2020) Cold Exposure Increases Circulating miR-122 Levels via UCP1-Dependent Mechanism in Mice. Jpn J Vet Res, 68:187-195. 

4. Takatani N, Kono Y, Beppu F, Okamatsu-Ogura Y, Yamano Y, Miyashita K, Hosokawa M*. (2020) Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice. Biochem Biophys Res Commun, 528:305-310. 

5. Sakamoto KQ*, Okamatsu-Ogura Y. (2020) The effect of temperature acclimation on torpor expression pattern in mice. Jpn J Vet Res, 68:55-62. 

6. Nasoori A, Okamatsu-Ogura Y, Shimozuru M, Sashika M, Tsubota T*. (2020) Hibernating bear serum hinders osteoclastogenesis in-vitro. PLoS One, 15:e0238132. 

7. Chuluunbaatar T, Ichii O*, Nakamura T, Irie T, Namba T, Islam MR, Otani Y, Masum MA, Okamatsu-Ogura Y, Elewa YHA, Kon Y. (2020) Unique Running Pattern and Mucosal Morphology Found in the Colon of Cotton Rats. Front Physiol, 11,:587214. 

Publications other than original articles

1. Saito M*, Matsushita M, Yoneshiro T, Okamatsu-Ogura Y. (2020) Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men. Front Endocrinol, 11:222. 

2019年

Original articles

1. Tsubota A, Okamatsu-Ogura Y*, Bariuan JV, Mae J, Matsuoka S, Nio-Kobayashi J, Kimura K. (2019) Role of brown adipose tissue in body temperature control during the early postnatal period in Syrian hamsters and mice. J Vet Med Sci, 81:1461-1467.

2. Shin W, Okamatsu-Ogura Y*, Matsuoka S, Tsubota A, Kimura, K. (2019) Impaired adrenergic agonist-dependent beige adipocyte induction in obese mice. J Vet Med Sci, 81:799-807. 

3.  Okamatsu-Ogura Y*, Matsushita M, Bariuan JV, Nagaya K, Tsubota A, Saito M. (2019) Association of circulating exosomal miR-122 levels with BAT activity in healthy humans. Sci Rep, 9:13243.

4. Yoneshiro T*, Shin W, Machida K, Fukano K, Tsubota A, Chen Y, Yasui H, Inanami O, Okamatsu-Ogura Y, Kimura K. (2019) Differentiation of bone marrow-derived cells toward thermogenic adipocytes in white adipose tissue induced by the beta3 adrenergic stimulation. FASEB J, 33:5196-5207.

5. Okura Y, Imao T, Murashima S, Shibata H, Kamikavwa A, Okamatsu-Ogura Y, Saito M, Kimura K*. (2019) Interaction of Nerve Growth Factor beta with Adiponectin and SPARC Oppositely Modulates its Biological Activity. Int J Mol Sci, 20(7):1541.

6. Nakajima S, Nishimoto Y, Tateya S, Iwahashi Y, Okamatsu-Ogura Y, Saito M, Ogawa W, Tamori Y*. (2019) Fat-specific protein 27alpha inhibits autophagy-dependent lipid droplet breakdown in white adipocytes. J Diabetes Investig, 10:1419-1429.

7. Kubo N, Kawahara M, Okamatsu-Ogura Y, Miyazaki Y, Otsuka R, Fukuchi K*. (2019) Evaluation of Glucose Uptake and Uncoupling Protein 1 Activity in Adipose Tissue of Diabetic Mice upon β-Adrenergic Stimulation. Mol Imaging Biol, 21:249-256.