MITO-DYNAMICS

In the MITO-DYNAMICS project, we want to understand the molecular, metabolic and structural changes that mitochondria – the biological powerhouses of all our cells – undergo in the muscle during ageing and in muscle wasting caused by a lack of exercise or by a disease such as cancer?

MITO-DYNAMICS (ANR-18-CE45-0016-01) is an interdisciplinary research projects financed by the ANR and unites four research teams at the Aix-Marseille University coming from computational, as well as experimental biology.

Composition of the interdisciplinary MITO-DYNAMICS research consoritum:

Team Habermann: Computational Biology (Aix-Marseille University, CNRS, IBDM UMR 7288, official team-website)

The computational biology team at the IBDM focuses on data analysis, integration and visual data mining (VMD). The VMD platform mitoXplorer will be central to the MITO-DYNAMICS project, providing the computational framework for data analysis, integration and visualization and help us understand the complex mitochondrial dynamics in the muscle and in muscle wasting during ageing.

Participiating team members: 
Bianca Habermann

Group Leader

Fabio Marchiano

PhD-student

financed by ANR

Team Schnorrer: Muscle Dynamics (Aix-Marseille University, CNRS, IBDM UMR 7288, official team web-site)

Frank Schnorrer, a cell and developmental biologist, pioneered the dynamic in vivo studies of muscle morphogenesis over the last 10 years. Using the strength of Drosophila, he was able to systematically identify genes essential for muscle fate specification and myofibrillogenesis. With this grant the lab will extend to investigate mitochondrial dynamics in the fly muscle model.

Participiating team members: 
Frank Schnorrer

Group Leader

Nuno Luis

CRCN

Jerome Avellaneda

PhD-student

Christophe Pitaval

Engineer

Team Carrier: Cellular Stress (Aix-Marseille University, CNRS, INSERM, CRCM UMR 1068)

The team of Alice Carrier is interested since many years in the link between inflammation, oxidative stress and cancer. The general objective of her team is to unveil the impact of mitochondria in pancreatic cancer cells aggressiveness and resistance to therapy, allowing the development of new preclinical assays targeting mitochondria. In this grant, she will turn her attention to the role of mitochondria and mitochondrial metabolism in muscle wasting during ageing and in a pancreatic cancer mouse model.

Participiating team members: 
Alice Carrier

Group Leader

Tristan Gicquel

CDD

financed by ANR

Rawand Masoud

CDD Postdoc Fondation ARC

Gabriela Reyes-Castellanos

PhD Conacyt Fellowship

Laurence Borge

AI (INSERM)

Team Giannesini: Musculoskeletal System (Aix-Marseille University, CNRS, CRMBM UMR 7339)

Benoit's team are experts in the noninvasive investigation of skeletal muscle function using multimodal nuclear magnetic resonance methods. His team possesses knowledge and state-of-art equipment without equivalent in the world for assessing muscle anatomy, mechanical performance and bioenergetics in normal and pathological murine models. Especially, Benoit’s research focuses on the in vivo characterization of mitochondrial capacity and regulation under healthy and pathophysiological conditions, as well as the evaluation of pharmaceutical and behavioral therapeutic approaches for improving mitochondrial function in vivo.

Participiating team members: 
Benoit Giannesini

Group Leader

Nathalie Cuge

Tech CNRS HC

Christophe Vilmen

Tech AMU HC

Yann Lefur

IRHC CNRS