In the MITO-DYNAMICS project, we want to understand the molecular, metabolic and structural changes that mitochondria – the biological powerhouses of all our cells – undergo in the muscle during ageing and in muscle wasting caused by a lack of exercise or by a disease such as cancer?
MITO-DYNAMICS (ANR-18-CE45-0016-01) is an interdisciplinary research projects financed by the ANR and unites four research teams at the Aix-Marseille University coming from computational, as well as experimental biology.
Composition of the interdisciplinary MITO-DYNAMICS research consoritum:
The computational biology team at the IBDM focuses on data analysis, integration and visual data mining (VMD). The VMD platform mitoXplorer will be central to the MITO-DYNAMICS project, providing the computational framework for data analysis, integration and visualization and help us understand the complex mitochondrial dynamics in the muscle and in muscle wasting during ageing.
financed by ANR
Frank Schnorrer, a cell and developmental biologist, pioneered the dynamic in vivo studies of muscle morphogenesis over the last 10 years. Using the strength of Drosophila, he was able to systematically identify genes essential for muscle fate specification and myofibrillogenesis. With this grant the lab will extend to investigate mitochondrial dynamics in the fly muscle model.
The team of Alice Carrier is interested since many years in the link between inflammation, oxidative stress and cancer. The general objective of her team is to unveil the impact of mitochondria in pancreatic cancer cells aggressiveness and resistance to therapy, allowing the development of new preclinical assays targeting mitochondria. In this grant, she will turn her attention to the role of mitochondria and mitochondrial metabolism in muscle wasting during ageing and in a pancreatic cancer mouse model.
financed by ANR
CDD Postdoc Fondation ARC
PhD Conacyt Fellowship
Benoit's team are experts in the noninvasive investigation of skeletal muscle function using multimodal nuclear magnetic resonance methods. His team possesses knowledge and state-of-art equipment without equivalent in the world for assessing muscle anatomy, mechanical performance and bioenergetics in normal and pathological murine models. Especially, Benoit’s research focuses on the in vivo characterization of mitochondrial capacity and regulation under healthy and pathophysiological conditions, as well as the evaluation of pharmaceutical and behavioral therapeutic approaches for improving mitochondrial function in vivo.
Tech CNRS HC
Tech AMU HC
Publications funded by the MITO-DYNAMICS research grant:
Jerome Avellaneda, Clement Rodier, Fabrice Daian, Thomas Rival, Nuno Miguel Luis, Frank Schnorrer. Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle. biorXiv 2020. doi: https://doi.org/10.1101/2020.07.18.209957.
Kaya-Çopur A, Marchiano F, Hein MY, Alpern D, Russeil J, Luis NM, Mann M, Deplancke B, Habermann BH, Schnorrer F. The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression. Elife. 2021 Jan 6;10:e63726. doi: 10.7554/eLife.63726. PMID: 33404503; PMCID: PMC7815313.
Yim A, Koti P, Bonnard A, Marchiano F, Dürrbaum M, Garcia-Perez C, Villaveces J, Gamal S, Cardone G, Perocchi F, Storchova Z, Habermann BH. mitoXplorer, a visual data mining platform to systematically analyze and visualize mitochondrial expression dynamics and mutations. Nucleic Acids Res. 2020 Jan 24;48(2):605-632. doi: 10.1093/nar/gkz1128. PubMed PMID: 31799603; PubMed Central PMCID:PMC6954439.